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    Tada3 transcriptional adaptor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362414, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tada3provided by RGD
    Official Full Name
    transcriptional adaptor 3provided by RGD
    Primary source
    RGD:1564009
    See related
    EnsemblRapid:ENSRNOG00000008597 AllianceGenome:RGD:1564009
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tada3l
    Summary
    Predicted to enable nuclear receptor binding activity; nuclear receptor coactivator activity; and protein domain specific binding activity. Predicted to be involved in several processes, including regulation of cell division; regulation of embryonic development; and regulation of gene expression. Predicted to act upstream of or within several processes, including chromatin organization; regulation of protein modification process; and regulation of protein stability. Predicted to be located in mitotic spindle and nucleoplasm. Predicted to be part of ATAC complex; SAGA complex; and transcription factor TFTC complex. Orthologous to human TADA3 (transcriptional adaptor 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 106.6), Lung (RPKM 81.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tada3 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (148065859..148077347, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (146510213..146521975, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (145318417..145330291, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin-dependent protein kinase I Neighboring gene chaperonin containing TCP1 subunit 3, pseudogene 6 Neighboring gene gamma-glutamylamine cyclotransferase, pseudogene 2 Neighboring gene U2 spliceosomal RNA Neighboring gene actin related protein 2/3 complex, subunit 4 Neighboring gene tubulin tyrosine ligase like 3 Neighboring gene RNA pseudouridine synthase D3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Deregulated expression of a novel component of TFTC/STAGA histone acetyltransferase complexes, rat SGF29, in hepatocellular carcinoma: possible implication for the oncogenic potential of c-Myc. Kurabe N, et al. Oncogene, 2007 Aug 16. PMID 17334388
    2. ADA3-containing complexes associate with estrogen receptor alpha. Benecke A, et al. Nucleic Acids Res, 2002 Jun 1. PMID 12034840, Free PMC Article
    3. Human ADA3 regulates RARalpha transcriptional activity through direct contact between LxxLL motifs and the receptor coactivator pocket. Li CW, et al. Nucleic Acids Res, 2010 Sep. PMID 20413580, Free PMC Article
    4. The ATAC acetyl transferase complex controls mitotic progression by targeting non-histone substrates. Orpinell M, et al. EMBO J, 2010 Jul 21. PMID 20562830, Free PMC Article
    5. The double-histone-acetyltransferase complex ATAC is essential for mammalian development. Guelman S, et al. Mol Cell Biol, 2009 Mar. PMID 19103755, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC114459

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within chromatin organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of protein stability ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of tubulin deacetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of tubulin deacetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ATAC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of SAGA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SAGA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFTC complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    transcriptional adapter 3
    Names
    ADA3 homolog
    ADA3-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025734.1 → NP_001020905.1  transcriptional adapter 3

      See identical proteins and their annotated locations for NP_001020905.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097414
      UniProtKB/Swiss-Prot
      Q4V8F5
      UniProtKB/TrEMBL
      A6IBQ8
      Related
      ENSRNOP00000077680.2, ENSRNOT00000112548.2
      Conserved Domains (1) summary
      pfam10198
      Location:309 → 422
      Ada3; Histone acetyltransferases subunit 3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      148065859..148077347 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006237040.3 → XP_006237102.1  transcriptional adapter 3 isoform X1

      See identical proteins and their annotated locations for XP_006237102.1

      UniProtKB/TrEMBL
      A0A8I5Y660, A6IBQ8
      Conserved Domains (1) summary
      pfam10198
      Location:317 → 430
      Ada3; Histone acetyltransferases subunit 3

    2. XM_039107832.2 → XP_038963760.1  transcriptional adapter 3 isoform X2

      UniProtKB/Swiss-Prot
      Q4V8F5
      UniProtKB/TrEMBL
      A6IBQ8
      Conserved Domains (1) summary
      pfam10198
      Location:309 → 422
      Ada3; Histone acetyltransferases subunit 3

    3. XM_039107831.2 → XP_038963759.1  transcriptional adapter 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y660, A6IBQ8
      Related
      ENSRNOP00000011827.6, ENSRNOT00000011827.8
      Conserved Domains (1) summary
      pfam10198
      Location:317 → 430
      Ada3; Histone acetyltransferases subunit 3

    4. XM_063286292.1 → XP_063142362.1  transcriptional adapter 3 isoform X4

    5. XM_006237042.3 → XP_006237104.1  transcriptional adapter 3 isoform X2

      See identical proteins and their annotated locations for XP_006237104.1

      UniProtKB/Swiss-Prot
      Q4V8F5
      UniProtKB/TrEMBL
      A6IBQ8
      Conserved Domains (1) summary
      pfam10198
      Location:309 → 422
      Ada3; Histone acetyltransferases subunit 3

    6. XM_006237043.3 → XP_006237105.1  transcriptional adapter 3 isoform X3

      UniProtKB/TrEMBL
      A6IBQ8
      Conserved Domains (1) summary
      pfam10198
      Location:268 → 368
      Ada3; Histone acetyltransferases subunit 3

    7. XM_063286291.1 → XP_063142361.1  transcriptional adapter 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I5Y660

    8. XM_039107833.2 → XP_038963761.1  transcriptional adapter 3 isoform X5

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4V8F5.1 GenPept UniProtKB/Swiss-Prot:Q4V8F5

    Gene LinkOut

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