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    Nup205 nucleoporin 205 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362335, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Nup205provided by RGD
    Official Full Name
    nucleoporin 205provided by RGD
    Primary source
    RGD:1309413
    See related
    EnsemblRapid:ENSRNOG00000010852 AllianceGenome:RGD:1309413
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be a structural constituent of nuclear pore. Predicted to be involved in nuclear pore complex assembly. Predicted to be located in nuclear membrane and nuclear periphery. Predicted to be part of nuclear pore inner ring. Human ortholog(s) of this gene implicated in nephrotic syndrome type 13. Orthologous to human NUP205 (nucleoporin 205). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 179.5), Spleen (RPKM 124.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nup205 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (64822051..64887996)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (63854934..63920852)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (62703779..62773931)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692099 Neighboring gene solute carrier family 23 member 4 Neighboring gene CCR4-NOT transcription complex, subunit 4 Neighboring gene uncharacterized LOC102553126 Neighboring gene large ribosomal subunit protein eL38-like Neighboring gene short transmembrane mitochondrial protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Nucleoporins as components of the nuclear pore complex core structure and Tpr as the architectural element of the nuclear basket. Krull S, et al. Mol Biol Cell, 2004 Sep. PMID 15229283, Free PMC Article
    2. Direct interaction with nup153 mediates binding of Tpr to the periphery of the nuclear pore complex. Hase ME, et al. Mol Biol Cell, 2003 May. PMID 12802065, Free PMC Article
    3. JUNB-FBXO21-ERK axis promotes cartilage degeneration in osteoarthritis by inhibiting autophagy. Lin Z, et al. Aging Cell, 2021 Feb. PMID 33450132, Free PMC Article
    4. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear pore complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear pore organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleocytoplasmic transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear periphery ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore inner ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nuclear pore complex protein Nup205
    Names
    nucleoporin 205kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108620.1 → NP_001102090.1  nuclear pore complex protein Nup205

      See identical proteins and their annotated locations for NP_001102090.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473959
      UniProtKB/TrEMBL
      A6IEN8, D4A7R3
      Conserved Domains (1) summary
      pfam11894
      Location:14 → 1684
      Nup192; Nuclear pore complex scaffold, nucleoporins 186/192/205

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      64822051..64887996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107776.2 → XP_038963704.1  nuclear pore complex protein Nup205 isoform X1

      UniProtKB/TrEMBL
      D4A7R3
      Related
      ENSRNOP00000076488.2, ENSRNOT00000098985.2
      Conserved Domains (1) summary
      pfam11894
      Location:206 → 1725
      Nup192; Nuclear pore complex scaffold, nucleoporins 186/192/205

    2. XM_008762797.3 → XP_008761019.1  nuclear pore complex protein Nup205 isoform X2

      See identical proteins and their annotated locations for XP_008761019.1

      UniProtKB/TrEMBL
      A0A8I6GHV1, D4A7R3
      Related
      ENSRNOP00000014833.6, ENSRNOT00000014832.7
      Conserved Domains (1) summary
      pfam11894
      Location:3 → 1573
      Nup192; Nuclear pore complex scaffold, nucleoporins 186/192/205

    3. XM_039107777.1 → XP_038963705.1  nuclear pore complex protein Nup205 isoform X3

      Conserved Domains (1) summary
      cl29134
      Location:1 → 879
      Nup188; Nucleoporin subcomplex protein binding to Pom34
    Nucleotide Protein Strain
    Heading Accession and Version

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