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    Rps6kb2 ribosomal protein S6 kinase B2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361696, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Rps6kb2provided by RGD
    Official Full Name
    ribosomal protein S6 kinase B2provided by RGD
    Primary source
    RGD:1305144
    See related
    EnsemblRapid:ENSRNOG00000021689 AllianceGenome:RGD:1305144
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables ATP binding activity; peptide binding activity; and ribosomal protein S6 kinase activity. Involved in protein phosphorylation. Predicted to be located in ribosome. Predicted to be active in cytoplasm and nucleus. Orthologous to human RPS6KB2 (ribosomal protein S6 kinase B2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 101.7), Lung (RPKM 72.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rps6kb2 in Genome Data Viewer
    Location:
    1q43
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210880824..210887556, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201451265..201458096, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219406201..219412888, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene coronin 1B Neighboring gene protein tyrosine phosphatase, receptor type, C-associated protein Neighboring gene carnosine synthase 1 Neighboring gene TBC1 domain family, member 10C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Lean and obese Zucker rats exhibit different patterns of p70s6 kinase regulation in the tibialis anterior muscle in response to high-force muscle contraction. Katta A, et al. Muscle Nerve, 2009 Apr. PMID 19296503, Free PMC Article
    2. Cross-talk between the ERK and p70 S6 kinase (S6K) signaling pathways. MEK-dependent activation of S6K2 in cardiomyocytes. Wang L, et al. J Biol Chem, 2001 Aug 31. PMID 11431469
    3. The Coffin-Lowry syndrome-associated protein RSK2 controls neuroendocrine secretion through the regulation of phospholipase D1 at the exocytotic sites. Zeniou-Meyer M, et al. Ann N Y Acad Sci, 2009 Jan. PMID 19161391
    4. The Coffin-Lowry syndrome-associated protein RSK2 is implicated in calcium-regulated exocytosis through the regulation of PLD1. Zeniou-Meyer M, et al. Proc Natl Acad Sci U S A, 2008 Jun 17. PMID 18550821, Free PMC Article
    5. The effect of MK-801 on mTOR/p70S6K and translation-related proteins in rat frontal cortex. Yoon SC, et al. Neurosci Lett, 2008 Mar 21. PMID 18262357

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. insulin resistance is associated with alterations in the ability of muscle to activate p70S6k signaling following an acute bout of exercise
      Title: Lean and obese Zucker rats exhibit different patterns of p70s6 kinase regulation in the tibialis anterior muscle in response to high-force muscle contraction.
    2. RSK2 is a critical upstream signaling element in the activation of PLD1 to produce the lipids required for exocytosis
      Title: The Coffin-Lowry syndrome-associated protein RSK2 controls neuroendocrine secretion through the regulation of phospholipase D1 at the exocytotic sites.
    3. RSK2 is an essential modulator of PLD1 activity in calcium-regulated exocytosis.
      Title: The Coffin-Lowry syndrome-associated protein RSK2 is implicated in calcium-regulated exocytosis through the regulation of PLD1.
    4. Thus, proteins in the mTOR/p70S6K pathway are modulated in chronic MK-801 animal models.
      Title: The effect of MK-801 on mTOR/p70S6K and translation-related proteins in rat frontal cortex.
    5. phosphorylation of p70(s6k), likely via the Insulin-Like Growth Factor I pathway, may play an important role in androgen-induced skeletal muscle hypertrophy
      Title: Phosphorylation of p70s6 kinase is implicated in androgen-induced levator ani muscle anabolism in castrated rats.
    6. p122RhoGAP Ser-322 acts as an integrator of signal transduction in a manner dependent on the cellular context and is a substrate for protein kinase B and ribosomal S6 kinase
      Title: Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells.
    7. PKCalpha is implicated in CCK-induced activation of p70 S6 kinase in pancreatic acinar AR42J cells.
      Title: Protein kinase Calpha is implicated in cholecystokinin-induced activation of 70-kd S6 kinase in AR42J cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal protein S6 kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in TOR signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in TORC1 signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein S6 kinase beta-2
    Names
    ribosomal protein S6 kinase, 70kDa, polypeptide 2
    ribosomal protein S6 kinase, polypeptide 2
    NP_001010962.2
    XP_038939718.1
    XP_038939724.1
    XP_063124245.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010962.2 → NP_001010962.2  ribosomal protein S6 kinase beta-2

      See identical proteins and their annotated locations for NP_001010962.2

      Status: VALIDATED

      Source sequence(s)
      AW144793, CK843568, DY315655, DY561917
      UniProtKB/TrEMBL
      A6HYU9, D4AE24
      Related
      ENSRNOP00000068647.2, ENSRNOT00000083204.3
      Conserved Domains (1) summary
      cd05584
      Location:70 → 392
      STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      210880824..210887556 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268175.1 → XP_063124245.1  ribosomal protein S6 kinase beta-2 isoform X1

      Related
      ENSRNOP00000029993.6, ENSRNOT00000029580.7

    2. XM_039083796.2 → XP_038939724.1  ribosomal protein S6 kinase beta-2 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:1 → 192
      PKc_like; Protein Kinases, catalytic domain

    3. XM_039083790.2 → XP_038939718.1  ribosomal protein S6 kinase beta-2 isoform X2

      Conserved Domains (1) summary
      cl21453
      Location:1 → 192
      PKc_like; Protein Kinases, catalytic domain

    RNA

    1. XR_005488929.2 RNA Sequence

    2. XR_005488930.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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