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    Dusp8 dual specificity phosphatase 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361679, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Dusp8provided by RGD
    Official Full Name
    dual specificity phosphatase 8provided by RGD
    Primary source
    RGD:1306425
    See related
    EnsemblRapid:ENSRNOG00000029394 AllianceGenome:RGD:1306425
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hb5; M3/6
    Summary
    Predicted to enable phosphatase activity. Predicted to be involved in dephosphorylation. Predicted to be located in nucleus. Orthologous to human DUSP8 (dual specificity phosphatase 8). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Brain (RPKM 56.2), Muscle (RPKM 23.8) and 5 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dusp8 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (206596912..206613728, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (197167392..197184285, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (215030429..215043111, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485203 Neighboring gene BR serine/threonine kinase 2 Neighboring gene MOB kinase activator 2 Neighboring gene keratin associated protein 5-5 like 1 Neighboring gene keratin associated protein 5-2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Involvement of the dual-specificity phosphatase M3/6 in c-Jun N-terminal kinase inactivation following cerebral ischemia in the rat hippocampus. Huang Z, et al. Int J Neurosci, 2013 Nov. PMID 23679081
    2. DUSP8/TAK1 signaling mediates neuropathic pain through regulating neuroinflammation and neuron death in a spinal nerve ligation (SNL) rat model. Liao C, et al. Int Immunopharmacol, 2022 Dec. PMID 36279673
    3. hVH-5: a protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase. Martell KJ, et al. J Neurochem, 1995 Oct. PMID 7561881
    4. Regulation of MAP kinases by MAP kinase phosphatases. Kondoh K, et al. Biochim Biophys Acta, 2007 Aug. PMID 17208316
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DUSP8/TAK1 signaling mediates neuropathic pain through regulating neuroinflammation and neuron death in a spinal nerve ligation (SNL) rat model.
      Title: DUSP8/TAK1 signaling mediates neuropathic pain through regulating neuroinflammation and neuron death in a spinal nerve ligation (SNL) rat model.
    2. DUSP8 is upregulated following cerebral ischemia in hippocampus.
      Title: Involvement of the dual-specificity phosphatase M3/6 in c-Jun N-terminal kinase inactivation following cerebral ischemia in the rat hippocampus.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity protein phosphatase 8
    NP_001101980.1
    XP_038939432.1
    XP_038939435.1
    XP_038939443.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108510.1 → NP_001101980.1  dual specificity protein phosphatase 8

      See identical proteins and their annotated locations for NP_001101980.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473953
      UniProtKB/TrEMBL
      A6HY37, D3ZNK9
      Related
      ENSRNOP00000046497.6, ENSRNOT00000044565.7
      Conserved Domains (2) summary
      cd01446
      Location:10 → 137
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
      cd14645
      Location:150 → 300
      DSP_DUSP8; dual specificity phosphatase domain of dual specificity protein phosphatase 8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      206596912..206613728 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083515.2 → XP_038939443.1  dual specificity protein phosphatase 8 isoform X1

      UniProtKB/TrEMBL
      A6HY37, D3ZNK9
      Conserved Domains (2) summary
      cd01446
      Location:10 → 137
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
      cd14645
      Location:150 → 300
      DSP_DUSP8; dual specificity phosphatase domain of dual specificity protein phosphatase 8

    2. XM_039083507.2 → XP_038939435.1  dual specificity protein phosphatase 8 isoform X1

      UniProtKB/TrEMBL
      A6HY37, D3ZNK9
      Conserved Domains (2) summary
      cd01446
      Location:10 → 137
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
      cd14645
      Location:150 → 300
      DSP_DUSP8; dual specificity phosphatase domain of dual specificity protein phosphatase 8

    3. XM_039083504.1 → XP_038939432.1  dual specificity protein phosphatase 8 isoform X1

      UniProtKB/TrEMBL
      A6HY37, D3ZNK9
      Conserved Domains (2) summary
      cd01446
      Location:10 → 137
      DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
      cd14645
      Location:150 → 300
      DSP_DUSP8; dual specificity phosphatase domain of dual specificity protein phosphatase 8
    Nucleotide Protein Strain
    Heading Accession and Version

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