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    Me3 malic enzyme 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361602, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Me3provided by RGD
    Official Full Name
    malic enzyme 3provided by RGD
    Primary source
    RGD:1311070
    See related
    EnsemblRapid:ENSRNOG00000017311 AllianceGenome:RGD:1311070
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable NADP+ binding activity and malate dehydrogenase (decarboxylating) (NADP+) activity. Predicted to be involved in malate metabolic process and pyruvate metabolic process. Predicted to be active in mitochondrial matrix. Orthologous to human ME3 (malic enzyme 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 212.8), Muscle (RPKM 105.6) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Me3 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (152946595..153148026)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (143534024..143735551)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (153861535..154058608)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase 4A1, pseudogene 2 Neighboring gene uncharacterized LOC103691188 Neighboring gene serine protease 23 Neighboring gene uncharacterized LOC102549783 Neighboring gene uncharacterized LOC120099878 Neighboring gene coiled-coil domain containing 81 Neighboring gene uncharacterized LOC134483752

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial malic enzyme 3 is important for insulin secretion in pancreatic β-cells. Hasan NM, et al. Mol Endocrinol, 2015 Mar. PMID 25594249, Free PMC Article
    2. Purification, cDNA cloning and heterologous expression of the human mitochondrial NADP(+)-dependent malic enzyme. Loeber G, et al. Biochem J, 1994 Dec 15. PMID 7818469, Free PMC Article
    3. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    4. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The data suggest that ME3, far more than ME1 or ME2, is necessary for insulin release.
      Title: Mitochondrial malic enzyme 3 is important for insulin secretion in pancreatic β-cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP+ binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables malate dehydrogenase (decarboxylating) (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables malate dehydrogenase (decarboxylating) (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables malic enzyme activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in malate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in malate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pyruvate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyruvate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NADP-dependent malic enzyme, mitochondrial
    Names
    malic enzyme 3, NADP(+)-dependent, mitochondrial
    mitochondrial malic enzyme 3
    NP_001402901.1
    XP_006229728.1
    XP_063123049.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001415972.1 → NP_001402901.1  NADP-dependent malic enzyme, mitochondrial

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6AK15
      Related
      ENSRNOP00000089037.1, ENSRNOT00000095307.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      152946595..153148026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006229666.4 → XP_006229728.1  NADP-dependent malic enzyme, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A0G2K4C6, F1M5N4
      Related
      ENSRNOP00000023329.7, ENSRNOT00000023329.9
      Conserved Domains (3) summary
      cd05312
      Location:305 → 549
      NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
      PLN03129
      Location:9 → 554
      PLN03129; NADP-dependent malic enzyme; Provisional
      pfam00390
      Location:114 → 295
      malic; Malic enzyme, N-terminal domain

    2. XM_063266979.1 → XP_063123049.1  NADP-dependent malic enzyme, mitochondrial isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108491.2: Suppressed sequence

      Description
      NM_001108491.2: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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