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    Enah ENAH, actin regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360891, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Enahprovided by RGD
    Official Full Name
    ENAH, actin regulatorprovided by RGD
    Primary source
    RGD:1307666
    See related
    EnsemblRapid:ENSRNOG00000031934 AllianceGenome:RGD:1307666
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable SH3 domain binding activity; WW domain binding activity; and profilin binding activity. Involved in postsynaptic cytoskeleton organization. Is active in GABA-ergic synapse and postsynapse. Orthologous to human ENAH (ENAH actin regulator). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Adrenal (RPKM 290.1), Heart (RPKM 226.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Enah in Genome Data Viewer
    Location:
    13q26
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (96149437..96269841, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (93617747..93738119, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (100297421..100415335, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L36a-like Neighboring gene lamin B receptor Neighboring gene signal recognition particle 9 Neighboring gene uncharacterized LOC108352583

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Selectivity in subunit composition of Ena/VASP tetramers. Riquelme DN, et al. Biosci Rep, 2015 Jul 28. PMID 26221026, Free PMC Article
    2. Mena associates with Rac1 and modulates connexin 43 remodeling in cardiomyocytes. Ram R, et al. Am J Physiol Heart Circ Physiol, 2014 Jan 1. PMID 24186093, Free PMC Article
    3. Enabled homolog (ENAH) regulated by RNA binding protein splicing factor 3b subunit 4 (SF3B4) exacerbates the proliferation, invasion and migration of hepatocellular carcinoma cells via Notch signaling pathway. Deng G, et al. Bioengineered, 2022 Feb. PMID 35030977, Free PMC Article
    4. Structural basis for polyproline recognition by the FE65 WW domain. Meiyappan M, et al. J Mol Biol, 2007 Sep 28. PMID 17686488, Free PMC Article
    5. Mena is required for neurulation and commissure formation. Lanier LM, et al. Neuron, 1999 Feb. PMID 10069337

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables WW domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables profilin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables profilin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within actin polymerization or depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin polymerization-dependent cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin polymerization-dependent cell motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within axon guidance ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neural tube closure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in postsynaptic cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in filopodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein enabled homolog
    Names
    enabled homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012150.2 → NP_001012150.1  protein enabled homolog isoform 2

      See identical proteins and their annotated locations for NP_001012150.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6JGK5, Q5XHX3
      Related
      ENSRNOP00000112465.1, ENSRNOT00000171057.1
      Conserved Domains (3) summary
      cd01207
      Location:25 → 132
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam06012
      Location:430 → 500
      DUF908; Domain of Unknown Function (DUF908)
      pfam08776
      Location:489 → 522
      VASP_tetra; VASP tetramerization domain

    2. NM_001401377.1 → NP_001388306.1  protein enabled homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I5ZT50, A6JGK6
      Related
      ENSRNOP00000081655.1, ENSRNOT00000098544.2

    3. NM_001415736.1 → NP_001402665.1  protein enabled homolog isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      Related
      ENSRNOP00000081404.1, ENSRNOT00000097600.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      96149437..96269841 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272503.1 → XP_063128573.1  protein enabled homolog isoform X11

    2. XM_063272502.1 → XP_063128572.1  protein enabled homolog isoform X10

    3. XM_063272500.1 → XP_063128570.1  protein enabled homolog isoform X9

    4. XM_063272497.1 → XP_063128567.1  protein enabled homolog isoform X6

      Related
      ENSRNOP00000109230.1, ENSRNOT00000153721.1

    5. XM_063272494.1 → XP_063128564.1  protein enabled homolog isoform X2

      UniProtKB/TrEMBL
      A0A8I5Y4S4
      Related
      ENSRNOP00000076584.1, ENSRNOT00000109962.2

    6. XM_063272499.1 → XP_063128569.1  protein enabled homolog isoform X8

    7. XM_063272498.1 → XP_063128568.1  protein enabled homolog isoform X7

      UniProtKB/TrEMBL
      A0A0G2K6I4
      Related
      ENSRNOP00000073827.2, ENSRNOT00000085188.3

    8. XM_063272496.1 → XP_063128566.1  protein enabled homolog isoform X5

    9. XM_039090926.2 → XP_038946854.1  protein enabled homolog isoform X3

      UniProtKB/TrEMBL
      A0A8I6G5W6
      Conserved Domains (4) summary
      PLN03209
      Location:361 → 537
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      cd01207
      Location:25 → 132
      EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
      pfam08776
      Location:767 → 801
      VASP_tetra; VASP tetramerisation domain
      cd22185
      Location:619 → 645
      WH2_hVASP-like; Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of human Vasodilator-stimulated phosphoprotein and related proteins

    10. XM_063272493.1 → XP_063128563.1  protein enabled homolog isoform X1

    11. XM_063272506.1 → XP_063128576.1  protein enabled homolog isoform X15

    12. XM_063272495.1 → XP_063128565.1  protein enabled homolog isoform X4

    13. XM_063272505.1 → XP_063128575.1  protein enabled homolog isoform X14

    14. XM_039090933.2 → XP_038946861.1  protein enabled homolog isoform X12

      Conserved Domains (2) summary
      pfam08776
      Location:405 → 439
      VASP_tetra; VASP tetramerisation domain
      cd22185
      Location:236 → 262
      WH2_hVASP-like; Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of human Vasodilator-stimulated phosphoprotein and related proteins

    15. XM_063272504.1 → XP_063128574.1  protein enabled homolog isoform X13

    Nucleotide Protein Strain
    Heading Accession and Version

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