IL13 interleukin 13 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IL13provided by HGNC
Official Full Name: interleukin 13provided by HGNC
Primary source: HGNC:HGNC:5973
See related: Ensembl:ENSG00000169194 MIM:147683; AllianceGenome:HGNC:5973
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: P600; IL-13
Summary: This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
Expression: Restricted expression toward testis (RPKM 13.9) See more
Orthologs: mouse all
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Genomic context

Location:: 5q31.1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (132656522..132661110)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (133176323..133180911)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (131992214..131996802)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association of IL13 polymorphisms with susceptibility to myocardial infarction: A case-control study in Chinese population.
Title: Association of IL13 polymorphisms with susceptibility to myocardial infarction: A case-control study in Chinese population.
Association of CTACK, IL-2, and IL-13 with increased risk of lung cancer: A Mendelian randomization study.
Title: Association of CTACK, IL-2, and IL-13 with increased risk of lung cancer: A Mendelian randomization study.
Seasonal distribution and correlation between IL-10 and IL-13 gene polymorphism and their expression in scabies-infected patients.
Title: Seasonal distribution and correlation between IL-10 and IL-13 gene polymorphism and their expression in scabies-infected patients.
A call for clinical trials in glioblastoma multiforme for interleukin 4, interleukin 6, interleukin 13 and CD40.
Title: A call for clinical trials in glioblastoma multiforme for interleukin 4, interleukin 6, interleukin 13 and CD40.
Association of IL-13 rs20541, FOXP3 rs3761548 genes polymorphisms and serum level of IL-13 with allergic asthma in Egyptian patients.
Title: Association of IL-13 rs20541, FOXP3 rs3761548 genes polymorphisms and serum level of IL-13 with allergic asthma in Egyptian patients.
Interleukin 13-Induced Inflammation Increases DPP4 Abundance but Does Not Enhance Middle East Respiratory Syndrome Coronavirus Replication in Airway Epithelia.
Title: Interleukin 13-Induced Inflammation Increases DPP4 Abundance but Does Not Enhance Middle East Respiratory Syndrome Coronavirus Replication in Airway Epithelia.
Epithelial overexpression of IL-33 induces eosinophilic esophagitis dependent on IL-13.
Title: Epithelial overexpression of IL-33 induces eosinophilic esophagitis dependent on IL-13.
The association of 25(OH)D, interleukin-4, interleukin-5, and interleukin-13 levels with the burden of soil-transmitted helminth infection in stunted children aged 24-59 months.
Title: The association of 25(OH)D, interleukin-4, interleukin-5, and interleukin-13 levels with the burden of soil-transmitted helminth infection in stunted children aged 24-59 months.
Multiple sclerosis susceptibility may be associated with the coding rs20541 (R130Q) IL-13 gene polymorphism in the Polish population.
Title: Multiple sclerosis susceptibility may be associated with the coding rs20541 (R130Q) IL-13 gene polymorphism in the Polish population.
IL-4 and IL-13 induce equivalent expression of traditional M2 markers and modulation of reactive oxygen species in human macrophages.
Title: IL-4 and IL-13 induce equivalent expression of traditional M2 markers and modulation of reactive oxygen species in human macrophages.

Submit: New GeneRIF Correction See all GeneRIFs (560)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Allergic rhinitis, susceptibility to MedGen: C4017540 OMIM: 607154 GeneReviews: Not available	not available
Inherited susceptibility to asthma MedGen: C1869116 OMIM: 600807 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis. EBI GWAS Catalog EBI GWAS CatalogPubMed
A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. EBI GWAS Catalog EBI GWAS CatalogPubMed
A large-scale, consortium-based genomewide association study of asthma. EBI GWAS Catalog EBI GWAS CatalogPubMed
A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. EBI GWAS Catalog EBI GWAS CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 induces release of IL-13 in CD4+ T cells	PubMed
	env	HIV-1 gp120 induces IL-4 and IL-13 releases from human basophils through its interaction with the VH3 region of IgE	PubMed
	env	HIV-1 gp120 modulates expression of the cytokines IL1beta, IL3, IL6, IL10, IL13, IL15, IFNbeta2A, IFNgamma, IFNomega, TNFalpha, VEGF, VEGF B, and LIF in PBMCs and MDMs	PubMed
Envelope transmembrane glycoprotein gp41	env	A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 inhibits activation of PBMCs and upregulates the expression of IL-13 in peptide-treated PBMCs	PubMed
Tat	tat	HIV-1 Tat induces IL-4 and IL-13 release from basophils, leading to dysregulation of the IgE/Fc epsilon RI network	PubMed
reverse transcriptase	gag-pol	IL-13 can act on macrophages both before and after HIV-1 infection to interfere with virus replication by blocking the completion of reverse transcription, decreasing virus production, and reducing the infectivity of the progeny virions	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ECD09780 (e-PCR)
- UniSTS:290821

ECD10847 (e-PCR)
- UniSTS:291886

ECD09846 (e-PCR)
- UniSTS:290887

stSG601429 (e-PCR)
- UniSTS:444236

ECD00324 (e-PCR)
- UniSTS:281437

IL13_148 (e-PCR)
- UniSTS:277363

PMC356970P3 (e-PCR)
- UniSTS:273285

ECD05278 (e-PCR)
- UniSTS:286344

NoName (e-PCR)
- UniSTS:482731

REN71151 (e-PCR)
- UniSTS:395951

REN71152 (e-PCR)
- UniSTS:395952

REN71153 (e-PCR)
- UniSTS:395953

REN71154 (e-PCR)
- UniSTS:395954

REN71155 (e-PCR)
- UniSTS:395955

REN71156 (e-PCR)
- UniSTS:395956

REN71157 (e-PCR)
- UniSTS:395957

REN71158 (e-PCR)
- UniSTS:395958

REN71159 (e-PCR)
- UniSTS:395959

REN71160 (e-PCR)
- UniSTS:395960

REN71161 (e-PCR)
- UniSTS:395961

REN71162 (e-PCR)
- UniSTS:395962

REN71163 (e-PCR)
- UniSTS:395963

REN71164 (e-PCR)
- UniSTS:395964

REN71165 (e-PCR)
- UniSTS:395965

REN71166 (e-PCR)
- UniSTS:395966

REN71167 (e-PCR)
- UniSTS:395967

REN71168 (e-PCR)
- UniSTS:395968

REN71169 (e-PCR)
- UniSTS:395969

REN71170 (e-PCR)
- UniSTS:395970

REN71171 (e-PCR)
- UniSTS:395971

REN71172 (e-PCR)
- UniSTS:395972

REN71173 (e-PCR)
- UniSTS:395973

ECD09979 (e-PCR)
- UniSTS:291019

D5S2410 (e-PCR)
- UniSTS:76255

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine activity	IDA Inferred from Direct Assay more info	PubMed
enables interleukin-13 receptor binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in interleukin-13-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in macrophage activation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in microglial cell activation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of complement-dependent cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of endothelial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of lung ciliated cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of transforming growth factor beta production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of B cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of connective tissue growth factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of immunoglobulin production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-10 production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of lung goblet cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of macrophage activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mast cell degranulation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of pancreatic stellate cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein secretion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of proton transport	IEA Inferred from Electronic Annotation more info
involved_in response to ethanol	IEA Inferred from Electronic Annotation more info
involved_in response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in response to nematode	IEA Inferred from Electronic Annotation more info
involved_in response to nicotine	IEA Inferred from Electronic Annotation more info
involved_in response to selenium ion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: interleukin-13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012090.1 RefSeqGene

Range

5001..7938

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001354991.2 → NP_001341920.1 interleukin-13 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).

Source sequence(s)

AC004039, AC004041

UniProtKB/TrEMBL

Q4VB51, Q4VB53

Conserved Domains (1) summary

cl11518
Location:1 → 79

IL4; Interleukin 4
NM_001354992.2 → NP_001341921.1 interleukin-13 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).

Source sequence(s)

AC004039, AC004041

UniProtKB/TrEMBL

Q4VB51, Q4VB53

Conserved Domains (1) summary

cl11518
Location:1 → 79

IL4; Interleukin 4
NM_001354993.2 → NP_001341922.1 interleukin-13 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).

Source sequence(s)

AC004039, AC004041

UniProtKB/TrEMBL

Q4VB51, Q4VB53

Conserved Domains (1) summary

cl11518
Location:1 → 79

IL4; Interleukin 4
NM_002188.3 → NP_002179.2 interleukin-13 isoform 1 precursor

See identical proteins and their annotated locations for NP_002179.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AC004039

Consensus CDS

CCDS4157.1

UniProtKB/Swiss-Prot

O43644, P35225, Q4VB52, Q9UDC7

UniProtKB/TrEMBL

Q4VB50

Related

ENSP00000304915.3, ENST00000304506.7

Conserved Domains (1) summary

pfam03487
Location:35 → 144

IL13; Interleukin-13