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    HNRNPCL1 heterogeneous nuclear ribonucleoprotein C like 1 [ Homo sapiens (human) ]

    Gene ID: 343069, updated on 17-Jun-2024

    Summary

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    Official Symbol
    HNRNPCL1provided by HGNC
    Official Full Name
    heterogeneous nuclear ribonucleoprotein C like 1provided by HGNC
    Primary source
    HGNC:HGNC:29295
    See related
    Ensembl:ENSG00000179172 AllianceGenome:HGNC:29295
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HNRPCL1
    Summary
    Enables identical protein binding activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    all
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    Genomic context

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    See HNRNPCL1 in Genome Data Viewer
    Location:
    1p36.21
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (12847377..12848720, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (12391388..12392731, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (12907230..12908573, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene PRAME family member 11 Neighboring gene PRAME family member 30, pseudogene Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:12919058-12920257 Neighboring gene PRAME family member 2 Neighboring gene PRAME family member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of DeltaNp63alpha protein interactions by mass spectrometry. Amoresano A, et al. J Proteome Res, 2010 Apr 5. PMID 20085233
    2. Regulation of alternative splicing by SRrp86 and its interacting proteins. Li J, et al. Mol Cell Biol, 2003 Nov. PMID 14559993, Free PMC Article
    3. Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon. Nguyen TV, et al. Mol Cell, 2016 Mar 17. PMID 26990986, Free PMC Article
    4. Nsp2 has the potential to be a drug target revealed by global identification of SARS-CoV-2 Nsp2-interacting proteins. Zheng YX, et al. Acta Biochim Biophys Sin (Shanghai), 2021 Aug 31. PMID 34159380
    5. Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy. Iradi MCG, et al. Sci Rep, 2018 Mar 6. PMID 29511296, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    heterogeneous nuclear ribonucleoprotein C-like 1
    Names
    hnRNP C-like-1
    hnRNP core protein C-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013631.3 → NP_001013653.1  heterogeneous nuclear ribonucleoprotein C-like 1

      See identical proteins and their annotated locations for NP_001013653.1

      Status: VALIDATED

      Source sequence(s)
      AC245034
      Consensus CDS
      CCDS30591.1
      UniProtKB/Swiss-Prot
      B2RP44, O60812
      UniProtKB/TrEMBL
      A0A0G2JNQ3
      Related
      ENSP00000365370.4, ENST00000317869.7
      Conserved Domains (2) summary
      cd12341
      Location:16 → 83
      RRM_hnRNPC_like; RNA recognition motif in heterogeneous nuclear ribonucleoprotein C (hnRNP C)-related proteins
      pfam11719
      Location:171 → 288
      Drc1-Sld2; DNA replication and checkpoint protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      12847377..12848720 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_012132914.1 Reference GRCh38.p14 PATCHES

      Range
      28890..30233 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      12391388..12392731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O60812.1 GenPept UniProtKB/Swiss-Prot:O60812

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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