Pka-C1 Protein kinase, cAMP-dependent, catalytic subunit 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Pka-C1provided by FlyBase
Official Full Name: Protein kinase, cAMP-dependent, catalytic subunit 1provided by FlyBase
Primary source: FLYBASE:FBgn0000273
Locus tag: Dmel_CG4379
See related: AllianceGenome:FB:FBgn0000273
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 6353; C; CdkA; CG4379; Cos; Cos-1; cos1; Cos1; dc0; Dc0; DC0; dco; dcO; Dco; DCO; Dcpk; Dmel\CG4379; dPKA; l(2)01272; l(2)cos[[1]]; l(2)s4402; pka; pkA; pKA; Pka; PKA; pka C1; PKA CI; PKA Cl; Pka-C; PKA-C; pka-c1; pka-C1; PKA-C1; PKAc; PkaC1; PKAC1; PKAcA
Summary: Enables cAMP-dependent protein kinase activity. Involved in several processes, including oocyte axis specification; regulation of intracellular mRNA localization; and regulation of smoothened signaling pathway. Located in several cellular components, including cytosol; dendrite; and neuronal cell body. Is expressed in several structures, including ganglia; gland; gonad; gut section; and synaptic neuropil domain. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; fibrolamellar carcinoma; platelet-type bleeding disorder 19; and primary pigmented nodular adrenocortical disease 4. Orthologous to several human genes including PRKACA (protein kinase cAMP-activated catalytic subunit alpha) and PRKACB (protein kinase cAMP-activated catalytic subunit beta). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: all
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Genomic context

Location:: 30C5-30C5; 2-36 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (9682315..9699297, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (9682315..9699297, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The cAMP effector PKA mediates Moody GPCR signaling in Drosophila blood-brain barrier formation and maturation.
Title: The cAMP effector PKA mediates Moody GPCR signaling in Drosophila blood-brain barrier formation and maturation.
The authors show that PKA phosphorylates Meng Po and that both proteins synergize in a feedforward loop to control CREBB levels and long-term memory.
Title: A kinase-dependent feedforward loop affects CREBB stability and long term memory formation.
Early-onset sleep defects in mutated HTT Drosophila models of Huntington's disease reflect alterations of PKA/CREB signaling.
Title: Early-onset sleep defects in Drosophila models of Huntington's disease reflect alterations of PKA/CREB signaling.
Hedgehog signalling activation causes PKA to switch its substrates from Ci to Smo within the Hh signalling complex.
Title: Switch of PKA substrates from Cubitus interruptus to Smoothened in the Hedgehog signalosome complex.
tightly controlled dose-dependent intra-neuronal PKA activity levels are critical in determining the dendritic arbor complexity, one of the possible ways being through the regulation of organelle distribution.
Title: Developmental shaping of dendritic arbors in Drosophila relies on tightly regulated intra-neuronal activity of protein kinase A (PKA).
Alpha- NAC is a substrate of PKA following Parathyroid Hormone signaling.
Title: The PTH-Gαs-protein kinase A cascade controls αNAC localization to regulate bone mass.
that manipulations that increase cAMP/PKA signaling in adipokinetic hormone (AKH)-producing cells at the base of the neuroendocrine ring gland restore the dNf1 growth deficiency.
Title: Genetic and functional studies implicate synaptic overgrowth and ring gland cAMP/PKA signaling defects in the Drosophila melanogaster neurofibromatosis-1 growth deficiency.
Acute expression of protein kinase A inhibitory peptide in aged animals is sufficient to reverse age-related memory impairment in wild-type animals.
Title: Acute inhibition of PKA activity at old ages ameliorates age-related memory impairment in Drosophila.
Two-dimensional gel electrophoresis, (32)P labelling and immunodetection show that "in vitro" PKA phosphorylates the serine in the C-terminus of the NDUFS4 subunit in isolated bovine complex I.
Title: Phosphorylation pattern of the NDUFS4 subunit of complex I of the mammalian respiratory chain.
We found that decreased PKA activity in neurons rendered flies insensitive to the wake-promoting effects of octopamine.
Title: Octopamine regulates sleep in drosophila through protein kinase A-dependent mechanisms.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0085 (e-PCR)
- UniSTS:37159

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cAMP-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP-dependent protein kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cAMP-dependent protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in anesthesia-resistant memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in anterior/posterior pattern specification, imaginal disc	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cAMP-mediated signaling	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of nucleocytoplasmic transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte anterior/posterior axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oocyte microtubule cytoskeleton polarization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Atg1/ULK1 kinase complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of bicoid mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of circadian sleep/wake cycle, sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of pole plasm oskar mRNA localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rhythmic behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in sprouting of injured axon	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thermosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of cAMP-dependent protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein kinase, cAMP-dependent, catalytic subunit 1

Names: CG4379-PB; CG4379-PC; CG4379-PD; Costal-1; PKA catalytic subunit; Pka-C1-PB; Pka-C1-PC; Pka-C1-PD; cAMP-dependent protein kinase; cAMP-dependent protein kinase 1; catalytic subunit of PKA; catalytic subunit of cAMP-dependent protein kinase; costal; protein kinase A

NP_476977.1

EC 2.7.11.1

EC 2.7.11.11

NP_723479.1

EC 2.7.11.1

EC 2.7.11.11

NP_995672.1

EC 2.7.11.1

EC 2.7.11.11

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

9682315..9699297 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_164866.3 → NP_723479.1 protein kinase, cAMP-dependent, catalytic subunit 1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723479.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V0I0, P12370, Q9VL99

Related

FBpp0079448

Conserved Domains (1) summary

cd14209
Location:44 → 333

STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
NM_205950.3 → NP_995672.1 protein kinase, cAMP-dependent, catalytic subunit 1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_995672.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V0I0, P12370, Q9VL99

Conserved Domains (1) summary

cd14209
Location:44 → 333

STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
NM_057629.4 → NP_476977.1 protein kinase, cAMP-dependent, catalytic subunit 1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476977.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V0I0, P12370, Q9VL99

Related

FBpp0307466

Conserved Domains (1) summary

cd14209
Location:44 → 333

STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase