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    homer homer [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33944, updated on 2-Nov-2024

    Summary

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    Official Symbol
    homerprovided by FlyBase
    Official Full Name
    homerprovided by FlyBase
    Primary source
    FLYBASE:FBgn0025777
    Locus tag
    Dmel_CG11324
    See related
    AllianceGenome:FB:FBgn0025777
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BEST:LD03829; CG11324; dhom; Dhom; Dhomer; Dm Homer; Dmel\CG11324; Dvh; Hom; Homer; LD03829
    Summary
    Predicted to enable G protein-coupled glutamate receptor binding activity. Involved in behavioral response to ethanol; positive regulation of circadian sleep/wake cycle, sleep; and regulation of locomotion. Located in dendrite and endoplasmic reticulum. Is expressed in several structures, including brain; central nervous system; embryonic/larval midgut primordium; head epidermis primordium; and synaptic neuropil domain. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 68. Orthologous to several human genes including HOMER2 (homer scaffold protein 2) and HOMER3 (homer scaffold protein 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See homer in Genome Data Viewer
    Location:
    27A1-27A1; 2-22 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6719394..6723359, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6719394..6723359, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Adipokinetic hormone receptor Neighboring gene Apoptosis antagonizing transcription factor Neighboring gene Liprin-alpha Neighboring gene Tubulin tyrosine ligase-like 3B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila homer is required in a small set of neurons including the ellipsoid body for normal ethanol sensitivity and tolerance. Urizar NL, et al. J Neurosci, 2007 Apr 25. PMID 17460067, Free PMC Article
    2. Role of Homer proteins in the maintenance of sleep-wake states. Naidoo N, et al. PLoS One, 2012. PMID 22532843, Free PMC Article
    3. Genetic disruption of the putative binding site for Homer on DmGluRA reduces sleep in Drosophila. Ly S, et al. Sleep, 2020 Jan 13. PMID 31418019, Free PMC Article
    4. Genetic approaches to alcohol addiction: gene expression studies and recent candidates from Drosophila. Awofala AA. Invert Neurosci, 2011 Jun. PMID 21153676
    5. A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Gwack Y, et al. Nature, 2006 Jun 1. PMID 16511445

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables G protein-coupled glutamate receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled glutamate receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled glutamate receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled glutamate receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adult behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of circadian sleep/wake cycle, sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of locomotion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of store-operated calcium entry IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to ethanol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    homer
    Names
    CG11324-PA
    CG11324-PB
    CG11324-PD
    CG11324-PE
    CG11324-PF
    CG11324-PG
    d-Homer
    drosophila Ves-1 homolog
    homer-PA
    homer-PB
    homer-PD
    homer-PE
    homer-PF
    homer-PG
    NP_001260151.1
    • unusual splice
    NP_001260152.1
    • unusual splice

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      6719394..6723359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273221.1 → NP_001260150.1  homer, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260150.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPJ7, O96607
      Conserved Domains (2) summary
      cd01206
      Location:3 → 111
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
      cl23720
      Location:262 → 373
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    2. NM_164706.2 → NP_723207.1  homer, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723207.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPJ7, Q9VM94
      Related
      FBpp0078937
      Conserved Domains (2) summary
      cd01206
      Location:6 → 114
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
      cl23720
      Location:265 → 376
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    3. NM_001273222.1 → NP_001260151.1  homer, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260151.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPJ7, M9PEX1
      Conserved Domains (2) summary
      cd01206
      Location:9 → 117
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
      cl23720
      Location:268 → 379
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    4. NM_058048.4 → NP_477396.1  homer, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477396.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPJ7, O96607
      Related
      FBpp0078936
      Conserved Domains (2) summary
      cd01206
      Location:3 → 111
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
      cl23720
      Location:262 → 373
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    5. NM_001042876.2 → NP_001036341.2  homer, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036341.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E8S7
      Conserved Domains (1) summary
      cd01206
      Location:3 → 111
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain

    6. NM_001273223.1 → NP_001260152.1  homer, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260152.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C9QPJ7, M9PB54
      Conserved Domains (2) summary
      cd01206
      Location:6 → 114
      EVH1_Homer_Vesl; Homer/Vesl family proteins EVH1 domain
      cl23720
      Location:265 → 376
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PB54 M9PB54
    M9PEX1 M9PEX1
    O96607 O96607
    Q0E8S7 Q0E8S7
    Q9VM94 Q9VM94

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