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    Ifnl3 interferon lambda 3 [ Mus musculus (house mouse) ]

    Gene ID: 338374, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ifnl3provided by MGI
    Official Full Name
    interferon lambda 3provided by MGI
    Primary source
    MGI:MGI:2450574
    See related
    Ensembl:ENSMUSG00000060747 AllianceGenome:MGI:2450574
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Il28; IFL-1; Il28b; IL-28B; If1ia2; INF-alpha; INF-lambda
    Summary
    Predicted to enable interleukin-28 receptor binding activity. Acts upstream of or within innate immune response. Located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including COVID-19; cryoglobulinemia; dengue hemorrhagic fever; hepatitis C; and liver disease (multiple). Orthologous to several human genes including IFNL2 (interferon lambda 2) and IFNL3 (interferon lambda 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in adrenal adult (RPKM 1.2), thymus adult (RPKM 0.2) and 2 other tissues See more
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    Genomic context

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    See Ifnl3 in Genome Data Viewer
    Location:
    7 A3; 7 16.81 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28222251..28223826)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28522833..28524401)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8 pseudogene Neighboring gene interferon lambda 2 Neighboring gene cytochrome c, somatic pseudogene Neighboring gene syncollin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Antitumor activity of IFN-lambda in murine tumor models. Sato A, et al. J Immunol, 2006 Jun 15. PMID 16751416
    2. Lambda interferon is the predominant interferon induced by influenza A virus infection in vivo. Jewell NA, et al. J Virol, 2010 Nov. PMID 20739515, Free PMC Article
    3. IL-28A (IFN-λ2) modulates lung DC function to promote Th1 immune skewing and suppress allergic airway disease. Koltsida O, et al. EMBO Mol Med, 2011 Jun. PMID 21538995, Free PMC Article
    4. Interferon-λ mediates oral tolerance and inhibits antigen-specific, T-helper 2 cell-mediated inflammation in mouse intestine. He SH, et al. Gastroenterology, 2011 Jul. PMID 21569774
    5. Lambda interferon renders epithelial cells of the respiratory and gastrointestinal tracts resistant to viral infections. Mordstein M, et al. J Virol, 2010 Jun. PMID 20335250, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IFN-lambda3 is induced by Leishmania donovani and can inhibit parasite growth in cell line models but not in the mouse model, while it shows a significant association with leishmaniasis in humans.
      Title: IFN-λ3 is induced by Leishmania donovani and can inhibit parasite growth in cell line models but not in the mouse model, while it shows a significant association with leishmaniasis in humans.
    2. Interleukin-28B dampens protease-induced lung inflammation via IL-25 and TSLP inhibition in epithelial cells.
      Title: Interleukin-28B dampens protease-induced lung inflammation via IL-25 and TSLP inhibition in epithelial cells.
    3. Protective cellular and mucosal immune responses following nasal administration of a whole gamma-irradiated influenza A (subtype H1N1) vaccine adjuvanted with interleukin-28B in a mouse model.
      Title: Protective cellular and mucosal immune responses following nasal administration of a whole gamma-irradiated influenza A (subtype H1N1) vaccine adjuvanted with interleukin-28B in a mouse model.
    4. Selective Interferon Responses of Intestinal Epithelial Cells Minimize Tumor Necrosis Factor Alpha Cytotoxicity.
      Title: Selective Interferon Responses of Intestinal Epithelial Cells Minimize Tumor Necrosis Factor Alpha Cytotoxicity.
    5. Type I and III interferons disrupt lung epithelial repair during recovery from viral infection.
      Title: Type I and III interferons disrupt lung epithelial repair during recovery from viral infection.
    6. Type III interferons disrupt the lung epithelial barrier upon viral recognition.
      Title: Type III interferons disrupt the lung epithelial barrier upon viral recognition.
    7. IFN-lambda Decreases Murid Herpesvirus-4 Infection of the Olfactory Epithelium but Fails to Prevent Virus Reactivation in the Vaginal Mucosa.
      Title: IFN-λ Decreases Murid Herpesvirus-4 Infection of the Olfactory Epithelium but Fails to Prevent Virus Reactivation in the Vaginal Mucosa.
    8. Results support the idea of an exclusive role for known type III interferon cytokines in signaling via IFNLR to mediate antiviral effects at mucosal surfaces. These findings emphasize the importance of type III interferons in regulation of a variety of viral pathogens and provide important genetic evidence to support our understanding of the ligand-receptor interactions in this pathway.
      Title: Disruption of Type III Interferon (IFN) Genes Ifnl2 and Ifnl3 Recapitulates Loss of the Type III IFN Receptor in the Mucosal Antiviral Response.
    9. Study provides evidence that interferon-l3 promotes intestinal epithelial cell defense against Cryptosporidium parvum by inhibiting parasite invasion and mitigating loss of paracellular barrier function.
      Title: Interferon-λ3 Promotes Epithelial Defense and Barrier Function Against Cryptosporidium parvum Infection.
    10. The KH-type splicing regulatory protein (KSRP) regulates type III interferon expression post-transcriptionally.
      Title: The KH-type splicing regulatory protein (KSRP) regulates type III interferon expression post-transcriptionally.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5)  1 citation
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-28 receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of viral genome replication ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of interleukin-28 receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    interferon lambda-3
    Names
    IFN-lambda-3
    interferon 1ia2
    interferon alpha
    interleukin 28
    interleukin-28B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177396.1 → NP_796370.1  interferon lambda-3 precursor

      See identical proteins and their annotated locations for NP_796370.1

      Status: PROVISIONAL

      Source sequence(s)
      AY184375
      Consensus CDS
      CCDS21047.1
      UniProtKB/Swiss-Prot
      Q4VK73, Q8CGK6
      UniProtKB/TrEMBL
      B9EK98
      Related
      ENSMUSP00000077473.4, ENSMUST00000078364.4
      Conserved Domains (1) summary
      pfam15177
      Location:32 → 189
      IL28A; Interleukin-28A

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      28222251..28223826
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540130.2 → XP_006540193.1  interferon lambda-3 isoform X1

      Conserved Domains (2) summary
      PRK14971
      Location:58 → 240
      PRK14971; DNA polymerase III subunit gamma/tau
      pfam15177
      Location:32 → 142
      IL28A; Interleukin-28A
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CGK6.1 GenPept UniProtKB/Swiss-Prot:Q8CGK6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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