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    CHRNA1 cholinergic receptor nicotinic alpha 1 subunit [ Bos taurus (domestic cattle) ]

    Gene ID: 338070, updated on 4-Oct-2024

    Summary

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    Official Symbol
    CHRNA1provided by VGNC
    Official Full Name
    cholinergic receptor nicotinic alpha 1 subunitprovided by VGNC
    Primary source
    VGNC:VGNC:27322
    See related
    BGD:BT11902; Ensembl:ENSBTAG00000018253
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CHRNA1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 2 NC_037329.1 (22084351..22103937)

    Chromosome 2 - NC_037329.1Genomic Context describing neighboring genes Neighboring gene activating transcription factor 2 Neighboring gene chimerin 1 Neighboring gene non-histone chromosomal protein HMG-14-like Neighboring gene WAS/WASL interacting protein family member 1 Neighboring gene uncharacterized LOC107132241 Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037329.1 Chromosome 2 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and sequence analysis of calf cDNA and human genomic DNA encoding alpha-subunit precursor of muscle acetylcholine receptor. Noda M, et al. Nature, 1983 Oct 27-Nov 2. PMID 6688857
    2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables acetylcholine-gated monoatomic cation-selective channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    acetylcholine receptor subunit alpha
    Names
    cholinergic receptor, nicotinic, alpha 1 (muscle)
    cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176664.2 → NP_788837.1  acetylcholine receptor subunit alpha precursor

      See identical proteins and their annotated locations for NP_788837.1

      Status: PROVISIONAL

      Source sequence(s)
      X02509
      UniProtKB/Swiss-Prot
      P02709
      UniProtKB/TrEMBL
      A0AAA9TL58
      Related
      ENSBTAP00000024298.6, ENSBTAT00000024298.7
      Conserved Domains (2) summary
      pfam02931
      Location:24 → 231
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:238 → 446
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037329.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      22084351..22103937
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02709.1 GenPept UniProtKB/Swiss-Prot:P02709

    Gene LinkOut

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