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    mdm4 MDM4 regulator of p53 [ Danio rerio (zebrafish) ]

    Gene ID: 334932, updated on 27-Mar-2024

    Summary

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    Official Symbol
    mdm4provided by ZNC
    Official Full Name
    MDM4 regulator of p53provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6872
    See related
    Ensembl:ENSDARG00000057513 AllianceGenome:ZFIN:ZDB-GENE-030131-6872
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fa09h09; wu:fi33d10
    Summary
    Predicted to enable p53 binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of apoptotic process and regulation of cell cycle. Predicted to be active in nucleus. Orthologous to human MDM4 (MDM4 regulator of p53). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See mdm4 in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (22890997..22916641, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (22637973..22663617, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene si:ch211-86h15.1 Neighboring gene leucine rich repeat neuronal 2 Neighboring gene uncharacterized LOC110440099 Neighboring gene ATPase plasma membrane Ca2+ transporting 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular basis for the inhibition of p53 by Mdmx. Popowicz GM, et al. Cell Cycle, 2007 Oct 1. PMID 17938582
    2. Ionizing radiation induces a dramatic persistence of p53 protein accumulation and DNA damage signaling in mutant p53 zebrafish. Guo L, et al. Oncogene, 2013 Aug 22. PMID 23069659
    3. Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain. Popowicz GM, et al. Cell Cycle, 2008 Aug. PMID 18677113
    4. Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafish. Chua JS, et al. Oncogene, 2015 Nov 26. PMID 25746004, Free PMC Article
    5. The spliceosome factor sart3 regulates hematopoietic stem/progenitor cell development in zebrafish through the p53 pathway. Zhao Y, et al. Cell Death Dis, 2021 Oct 5. PMID 34611130, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein Mdm4
    Names
    MDM4, p53 regulator
    Mdm4, transformed 3T3 cell double minute 4, p53 binding protein
    double minute 4 protein
    mdm2-like p53-binding protein
    p53-binding protein Mdm4
    protein Mdmx
    transformed 3T3 cell double minute 4 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001328581.1 → NP_001315510.1  protein Mdm4 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BX545854, BX571949
      UniProtKB/Swiss-Prot
      Q4V944, Q7ZUW7
      UniProtKB/TrEMBL
      A0A8M2BK21, F1QD25
      Related
      ENSDARP00000074651.3, ENSDART00000080201.4
      Conserved Domains (3) summary
      pfam00641
      Location:309 → 334
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam02201
      Location:28 → 88
      SWIB; SWIB/MDM2 domain
      pfam13920
      Location:441 → 490
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    2. NM_212732.2 → NP_997897.2  protein Mdm4 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      BX545854, BX571949
      UniProtKB/Swiss-Prot
      Q4V944, Q7ZUW7
      UniProtKB/TrEMBL
      A0A8M2BKM9, X1WCV6
      Related
      ENSDARP00000128053.1, ENSDART00000154813.3
      Conserved Domains (3) summary
      pfam00641
      Location:304 → 329
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam02201
      Location:28 → 88
      SWIB; SWIB/MDM2 domain
      pfam13920
      Location:436 → 485
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      22890997..22916641 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005172871.4 → XP_005172928.1  protein Mdm4 isoform X2

      UniProtKB/Swiss-Prot
      Q4V944, Q7ZUW7
      UniProtKB/TrEMBL
      A0A8M2BKM9, X1WCV6
      Conserved Domains (3) summary
      pfam00641
      Location:304 → 329
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam02201
      Location:28 → 88
      SWIB; SWIB/MDM2 domain
      pfam13920
      Location:436 → 485
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    2. XM_005172869.4 → XP_005172926.1  protein Mdm4 isoform X1

      See identical proteins and their annotated locations for XP_005172926.1

      UniProtKB/Swiss-Prot
      Q4V944, Q7ZUW7
      UniProtKB/TrEMBL
      A0A8M2BK21, F1QD25
      Conserved Domains (3) summary
      pfam00641
      Location:309 → 334
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam02201
      Location:28 → 88
      SWIB; SWIB/MDM2 domain
      pfam13920
      Location:441 → 490
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7ZUW7.2 GenPept UniProtKB/Swiss-Prot:Q7ZUW7

    Gene LinkOut

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