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    Plc21C Phospholipase C at 21C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33204, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Plc21Cprovided by FlyBase
    Official Full Name
    Phospholipase C at 21Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004611
    Locus tag
    Dmel_CG4574
    See related
    AllianceGenome:FB:FBgn0004611
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4574; Dmel\CG4574; PLC; plc-21; PLC-21; PLC-21C; plc21; Plc21; plc21c; plc21C; Plc21c; PLC21c; PLC21C; plcbeta21c; Plcbeta21C; PLC[[Beta]]
    Summary
    Predicted to enable phosphatidylinositol phospholipase C activity. Involved in several processes, including entrainment of circadian clock by photoperiod; flight behavior; and positive regulation of canonical Wnt signaling pathway. Predicted to be active in cytoplasm. Is expressed in several structures, including adult brain; adult optic lobe; ganglia; gland; and head. Used to study obesity. Human ortholog(s) of this gene implicated in Alzheimer's disease; developmental and epileptic encephalopathy 12; myelodysplastic syndrome; and spondylometaphyseal dysplasia with corneal dystrophy. Orthologous to several human genes including PLCB1 (phospholipase C beta 1) and PLCB3 (phospholipase C beta 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

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    See Plc21C in Genome Data Viewer
    Location:
    21B8-21C1; 2-0.7 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (305935..355566)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (305935..355566)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Stress induced phosphoprotein 1 Neighboring gene Pi3K21B Neighboring gene long non-coding RNA:CR43719 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45367 Neighboring gene antisense RNA:CR45366 Neighboring gene Equilibrative nucleoside transporter 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ileal Crohn's Disease Exhibits Reduced Activity of Phospholipase C-β3-Dependent Wnt/β-Catenin Signaling Pathway. Ando T, et al. Cells, 2024 Jun 5. PMID 38891118, Free PMC Article
    2. Isolation and characterization of the droPIK57 gene encoding a new regulatory subunit of phosphatidylinositol 3-kinase from Drosophila melanogaster. Albert S, et al. Gene, 1997 Oct 1. PMID 9370280
    3. Receptor-evoked Cl- current in Xenopus oocytes is mediated through a beta-type phospholipase C. Cloning of a new form of the enzyme. Ma HW, et al. J Biol Chem, 1993 Sep 25. PMID 8397190
    4. Multiple subtypes of phospholipase C are encoded by the norpA gene of Drosophila melanogaster. Kim S, et al. J Biol Chem, 1995 Jun 16. PMID 7540168
    5. A Drosophila phospholipase C gene that is expressed in the central nervous system. Shortridge RD, et al. J Biol Chem, 1991 Jul 5. PMID 2061323

    See all (116) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Light Sampling via Throttled Visual Phototransduction Robustly Synchronizes the Drosophila Circadian Clock.
      Title: Light Sampling via Throttled Visual Phototransduction Robustly Synchronizes the Drosophila Circadian Clock.
    2. Galphaq, Ggamma1 and Plc21C are anti-obesity genes and Akh employs the Galphaq/Ggamma1/Plc21C module of iCa(2+) control to regulate lipid mobilization in adult Drosophila.
      Title: Gαq, Gγ1 and Plc21C control Drosophila body fat storage.
    3. Disruption of PLCb4 function completely blocked light-dependent modulation of Shab currents in Drosophila photoreceptors.
      Title: Light-dependent modulation of Shab channels via phosphoinositide depletion in Drosophila photoreceptors.
    4. Reduced odor responses from antennal neurons of phospholipase Cbeta mutants in Drosophila support a role for a phospholipid intermediate in insect olfactory transduction.
      Title: Reduced odor responses from antennal neurons of G(q)alpha, phospholipase Cbeta, and rdgA mutants in Drosophila support a role for a phospholipid intermediate in insect olfactory transduction.
    5. These results are consistent with a model in which phosphatidylinositol 4,5-bisphosphate hydrolysis acts via Ca2+ to activate myosin via MLCK and thereby control actin dynamics during constriction of the contractile ring.
      Title: Phospholipase C and myosin light chain kinase inhibition define a common step in actin regulation during cytokinesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol phospholipase C activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in entrainment of circadian clock by photoperiod IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in flight behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron cellular homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phosphatidylinositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuromuscular synaptic transmission IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phospholipase C at 21C
    Names
    CG4574-PA
    CG4574-PB
    CG4574-PC
    CG4574-PD
    CG4574-PG
    CG4574-PH
    Plc21C-PA
    Plc21C-PB
    Plc21C-PC
    Plc21C-PD
    Plc21C-PG
    Plc21C-PH
    phospholipase C
    phospholipase C 21C
    phospholipase c at 21c
    NP_001259818.1
    NP_476851.2
    NP_476852.1
    NP_995604.2
    NP_995605.1
    NP_995606.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      305935..355566
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_205884.3 → NP_995606.1  phospholipase C at 21C, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995606.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25455
      Conserved Domains (5) summary
      cd00275
      Location:736 → 855
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:317 → 702
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02222
      Location:213 → 850
      PLN02222; phosphoinositide phospholipase C 2
      cd13361
      Location:20 → 145
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam09279
      Location:225 → 317
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    2. NM_057504.5 → NP_476852.1  phospholipase C at 21C, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476852.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25455
      Related
      FBpp0077710
      Conserved Domains (5) summary
      cd00275
      Location:736 → 855
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:317 → 702
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02222
      Location:213 → 850
      PLN02222; phosphoinositide phospholipase C 2
      cd13361
      Location:20 → 145
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam09279
      Location:225 → 317
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    3. NM_001272889.1 → NP_001259818.1  phospholipase C at 21C, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259818.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25455
      Conserved Domains (4) summary
      cd00275
      Location:675 → 794
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:299 → 641
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      cd13361
      Location:20 → 145
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam09279
      Location:225 → 299
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    4. NM_205883.2 → NP_995605.1  phospholipase C at 21C, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995605.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4UZX5, M9PC05, P25455, Q0E8V1, Q7KTZ7, Q961D5, Q9VPN9
      Conserved Domains (5) summary
      cd00275
      Location:736 → 855
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:317 → 702
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02222
      Location:213 → 850
      PLN02222; phosphoinositide phospholipase C 2
      cd13361
      Location:20 → 145
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam09279
      Location:225 → 317
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    5. NM_057503.5 → NP_476851.2  phospholipase C at 21C, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476851.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25455
      Related
      FBpp0077711
      Conserved Domains (5) summary
      cd00275
      Location:736 → 855
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:317 → 702
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02222
      Location:213 → 850
      PLN02222; phosphoinositide phospholipase C 2
      cd13361
      Location:20 → 145
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam09279
      Location:225 → 317
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

    6. NM_205882.2 → NP_995604.2  phospholipase C at 21C, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995604.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25455
      Conserved Domains (5) summary
      cd00275
      Location:736 → 855
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08591
      Location:317 → 702
      PI-PLCc_beta; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta
      PLN02222
      Location:213 → 850
      PLN02222; phosphoinositide phospholipase C 2
      cd13361
      Location:20 → 145
      PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
      pfam09279
      Location:225 → 317
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25455.3 P25455

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