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    CoRest CoRest [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32941, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CoRestprovided by FlyBase
    Official Full Name
    CoRestprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261573
    Locus tag
    Dmel_CG42687
    See related
    AllianceGenome:FB:FBgn0261573
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH01486; BcDNA:LD11215; CG32534; CG32535; CG33525; CG3878; CG42687; CoREST; CoRESTG; dCoREST; Dmel\CG42687; i169
    Old locus tag
    Dmel_CG32534; Dmel_CG33525
    Summary
    Enables chromatin binding activity and transcription corepressor activity. Involved in negative regulation of DNA-templated transcription and positive regulation of DNA methylation-dependent heterochromatin formation. Located in nucleus. Part of transcription repressor complex. Is expressed in female germline cell; follicle cell; organism; and spermatozoon. Orthologous to human RCOR1 (REST corepressor 1); RCOR2 (REST corepressor 2); and RCOR3 (REST corepressor 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See CoRest in Genome Data Viewer
    Location:
    18C8-18C8; 1-62 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (19521929..19530896)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (19415962..19424929)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44340 Neighboring gene uncharacterized protein Neighboring gene 6-phosphofructo-2-kinase Neighboring gene Isocitrate dehydrogenase 3a Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Widespread regulatory specificities between transcriptional co-repressors and enhancers in Drosophila. Jacobs J, et al. Science, 2023 Jul 14. PMID 37440660
    2. Distinct CoREST complexes act in a cell-type-specific manner. Mačinković I, et al. Nucleic Acids Res, 2019 Dec 16. PMID 31701127, Free PMC Article
    3. The CoREST complex regulates multiple histone modifications temporal-specifically in clock neurons. Lv P, et al. Open Biol, 2024 Jul. PMID 38981515, Free PMC Article
    4. Aging and Intermittent Fasting Impact on Transcriptional Regulation and Physiological Responses of Adult Drosophila Neuronal and Muscle Tissues. Zhang S, et al. Int J Mol Sci, 2018 Apr 10. PMID 29642630, Free PMC Article
    5. CoREST acts as a positive regulator of Notch signaling in the follicle cells of Drosophila melanogaster. Domanitskaya E, et al. J Cell Sci, 2012 Jan 15. PMID 22331351, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila.
      Title: Rpd3/CoRest-mediated activity-dependent transcription regulates the flexibility in memory updating in Drosophila.
    2. This study uncovers three distinct dCoREST complexes that function in a lineage-restricted fashion to repress specific sets of genes thereby maintaining cell-type-specific gene expression programmes.
      Title: Distinct CoREST complexes act in a cell-type-specific manner.
    3. The data indicate that CoREST acts as a positive modulator of the Notch pathway in the follicular epithelium as well as in wing tissue, and suggests a previously unidentified role for CoREST in the regulation of Notch signaling.
      Title: CoREST acts as a positive regulator of Notch signaling in the follicle cells of Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of DNA methylation-dependent heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of histone deacetylase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription repressor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CoRest
    Names
    CG42687-PA
    CG42687-PC
    CG42687-PD
    CG42687-PE
    CG42687-PF
    CG42687-PG
    CG42687-PH
    CG42687-PI
    CG42687-PJ
    CG42687-PK
    CoRest-PA
    CoRest-PC
    CoRest-PD
    CoRest-PE
    CoRest-PF
    CoRest-PG
    CoRest-PH
    CoRest-PI
    CoRest-PJ
    CoRest-PK

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      19521929..19530896
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014754.1 → NP_001014754.1  CoRest, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014754.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3PFE5
      Conserved Domains (3) summary
      smart00717
      Location:179 → 225
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam01448
      Location:92 → 144
      ELM2; ELM2 domain
      cl21498
      Location:180 → 224
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    2. NM_001258824.1 → NP_001245753.1  CoRest, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245753.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAG1
      Conserved Domains (4) summary
      smart00717
      Location:179 → 225
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:540 → 582
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam01448
      Location:92 → 144
      ELM2; ELM2 domain
      cl21498
      Location:180 → 224
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    3. NM_001201742.3 → NP_001188671.1  CoRest, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188671.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAG1
      Conserved Domains (4) summary
      smart00717
      Location:179 → 225
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:540 → 582
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam01448
      Location:92 → 144
      ELM2; ELM2 domain
      cl21498
      Location:180 → 224
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    4. NM_001014752.4 → NP_001014752.2  CoRest, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014752.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V4S3, Q494F9, Q59E35, Q59E36, Q8MSX7, Q95TC9, Q9VWH3
      Conserved Domains (4) summary
      smart00717
      Location:179 → 225
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:306 → 348
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam01448
      Location:92 → 144
      ELM2; ELM2 domain
      cl21498
      Location:180 → 224
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    5. NM_001014753.3 → NP_001014753.1  CoRest, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014753.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q59E36
      Conserved Domains (4) summary
      smart00717
      Location:179 → 225
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:304 → 346
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam01448
      Location:92 → 144
      ELM2; ELM2 domain
      cl21498
      Location:180 → 224
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    6. NM_001258825.2 → NP_001245754.1  CoRest, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245754.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAG1
      Conserved Domains (4) summary
      smart00717
      Location:179 → 225
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:540 → 582
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      pfam01448
      Location:92 → 144
      ELM2; ELM2 domain
      cl21498
      Location:180 → 224
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    7. NM_001014755.2 → NP_001014755.1  CoRest, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014755.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3PFE5
      Conserved Domains (3) summary
      smart00717
      Location:179 → 225
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam01448
      Location:92 → 144
      ELM2; ELM2 domain
      cl21498
      Location:180 → 224
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    8. NM_001014756.2 → NP_001014756.1  CoRest, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014756.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3PFE5
      Conserved Domains (3) summary
      smart00717
      Location:179 → 225
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam01448
      Location:92 → 144
      ELM2; ELM2 domain
      cl21498
      Location:180 → 224
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    9. NM_001272777.1 → NP_001259706.1  CoRest, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259706.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3PFE5, M9PJR2
      Conserved Domains (3) summary
      smart00717
      Location:179 → 225
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam01448
      Location:92 → 144
      ELM2; ELM2 domain
      cl21498
      Location:180 → 224
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

    10. NM_001258826.1 → NP_001245755.1  CoRest, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245755.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D5SHV0, M9NHB6
      Conserved Domains (2) summary
      smart00717
      Location:52 → 97
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd00167
      Location:52 → 94
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C7LAG1 C7LAG1
    M9NHB6 M9NHB6
    M9PJR2 M9PJR2
    Q59E36.2 Q59E36

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