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    sordd1 suppression of retinal degeneration disease 1 upon overexpression 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32532, updated on 2-Nov-2024

    Summary

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    Official Symbol
    sordd1provided by FlyBase
    Official Full Name
    suppression of retinal degeneration disease 1 upon overexpression 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0030693
    Locus tag
    Dmel_CG8974
    See related
    AllianceGenome:FB:FBgn0030693
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8974; Dmel\CG8974
    Summary
    Enables ubiquitin protein ligase activity. Involved in positive regulation of ubiquitin-dependent protein catabolic process and protein ubiquitination. Is active in endoplasmic reticulum. Is expressed in several structures, including adult head; ganglia; gut section; and larval muscle system. Orthologous to human RNF185 (ring finger protein 185). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See sordd1 in Genome Data Viewer
    Location:
    13E18-13F1; 1-51 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15793721..15796028, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15687754..15690061, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S30 Neighboring gene Rhophilin Neighboring gene pseudo Neighboring gene suppression of retinal degeneration disease 1 upon overexpression 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Suppression of retinal degeneration by two novel ERAD ubiquitin E3 ligases SORDD1/2 in Drosophila. Xu J, et al. PLoS Genet, 2020 Nov. PMID 33137101, Free PMC Article
    2. PERK prevents rhodopsin degradation during retinitis pigmentosa by inhibiting IRE1-induced autophagy. Zhao N, et al. J Cell Biol, 2023 May 1. PMID 37022709, Free PMC Article
    3. Intrinsic maturation of sleep output neurons regulates sleep ontogeny in Drosophila. Gong NN, et al. Curr Biol, 2022 Sep 26. PMID 35985328, Free PMC Article
    4. Synteny of orthologous genes conserved in mammals, snake, fly, nematode, and fission yeast. Trachtulec Z, et al. Mamm Genome, 2001 Mar. PMID 11252172
    5. A screen for E3 ubiquitination ligases that genetically interact with the adaptor protein Cindr during Drosophila eye patterning. Ketosugbo KF, et al. PLoS One, 2017. PMID 29117266, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ubiquitin-like protein conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ubiquitin-dependent protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    suppression of retinal degeneration disease 1 upon overexpression 1
    Names
    CG8974-PA
    CG8974-PB
    CG8974-PC
    CG8974-PD
    CG8974-PE
    sordd1-PA
    sordd1-PB
    sordd1-PC
    sordd1-PD
    sordd1-PE
    suppression Of retinal degeneration disease 1 upon overexpression 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15793721..15796028 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206726.2 → NP_996449.1  suppression of retinal degeneration disease 1 upon overexpression 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996449.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXP1
      Conserved Domains (1) summary
      cd00162
      Location:124 → 169
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    2. NM_206725.2 → NP_996448.1  suppression of retinal degeneration disease 1 upon overexpression 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996448.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXP1
      Conserved Domains (1) summary
      cd00162
      Location:124 → 169
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    3. NM_167463.3 → NP_727897.1  suppression of retinal degeneration disease 1 upon overexpression 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727897.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXP1
      Related
      FBpp0073972
      Conserved Domains (1) summary
      cd00162
      Location:124 → 169
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    4. NM_132848.4 → NP_573076.1  suppression of retinal degeneration disease 1 upon overexpression 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573076.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXP1
      Related
      FBpp0073970
      Conserved Domains (1) summary
      cd00162
      Location:124 → 169
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    5. NM_167462.3 → NP_727896.1  suppression of retinal degeneration disease 1 upon overexpression 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727896.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VXP1
      Related
      FBpp0073971
      Conserved Domains (1) summary
      cd00162
      Location:124 → 169
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VXP1 Q9VXP1

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