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    septin8a septin 8a [ Danio rerio (zebrafish) ]

    Gene ID: 321590, updated on 2-Nov-2024

    Summary

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    Official Symbol
    septin8aprovided by ZNC
    Official Full Name
    septin 8aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-309
    See related
    Ensembl:ENSDARG00000032606 AllianceGenome:ZFIN:ZDB-GENE-030131-309
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    sept8; sept8a; fb22a03; wu:fb22a03
    Summary
    Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in cytoskeleton-dependent cytokinesis and protein localization. Predicted to be part of septin complex. Predicted to be active in cell division site; microtubule cytoskeleton; and septin ring. Is expressed in anterior lateral line nerve; brain; and medial longitudinal fasciculus. Orthologous to human SEPTIN8 (septin 8). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See septin8a in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (43328732..43374893)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (43333556..43379717)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene shroom family member 1 Neighboring gene ankyrin repeat domain-containing protein SOWAHA-like Neighboring gene cyclin I family, member 2 Neighboring gene FERM domain containing 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. sept8a and sept8b mRNA expression in the developing and adult zebrafish. Berger C, et al. Gene Expr Patterns, 2017 Nov. PMID 28414113
    2. Zebrafish null mutants of Sept6 and Sept15 are viable but more susceptible to Shigella infection. Torraca V, et al. Cytoskeleton (Hoboken), 2023 Jul-Aug. PMID 36855298, Free PMC Article
    3. Phylogenetic and evolutionary analysis of the septin protein family in metazoan. Cao L, et al. FEBS Lett, 2007 Nov 27. PMID 17967425
    4. Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism. Manchenkov T, et al. G3 (Bethesda), 2015 Apr 3. PMID 25840431, Free PMC Article
    5. Analysis of septins across kingdoms reveals orthology and new motifs. Pan F, et al. BMC Evol Biol, 2007 Jul 1. PMID 17601340, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    septin-8-A
    Names
    septin 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001115117.1 → NP_001108589.1  septin-8-A

      See identical proteins and their annotated locations for NP_001108589.1

      Status: PROVISIONAL

      Source sequence(s)
      BC081662
      UniProtKB/Swiss-Prot
      Q498W9, Q642H3, Q7SXT0
      Related
      ENSDARP00000102463.3, ENSDART00000109620.5
      Conserved Domains (3) summary
      cd01850
      Location:39 → 307
      CDC_Septin; CDC/Septin GTPase family
      COG5019
      Location:21 → 382
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam15290
      Location:330 → 377
      Syntaphilin; Golgi-localized syntaxin-1-binding clamp

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      43328732..43374893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q642H3.2 GenPept UniProtKB/Swiss-Prot:Q642H3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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