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    Lat2 linker for activation of T cells family, member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 317676, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Lat2provided by RGD
    Official Full Name
    linker for activation of T cells family, member 2provided by RGD
    Primary source
    RGD:631397
    See related
    EnsemblRapid:ENSRNOG00000021856 AllianceGenome:RGD:631397
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ntal; Wbscr5
    Summary
    Predicted to enable SH2 domain binding activity. Predicted to be involved in B cell activation; B cell receptor signaling pathway; and calcium-mediated signaling. Predicted to be located in membrane raft. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome. Orthologous to human LAT2 (linker for activation of T cells family member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 196.5), Thymus (RPKM 57.7) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Lat2 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (27740647..27754760)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (22104173..22118294)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (25114099..25128381)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene 40S ribosomal protein S14 pseudogene Neighboring gene eukaryotic translation initiation factor 4H Neighboring gene replication factor C subunit 2 Neighboring gene uncharacterized LOC102553558

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Topography of plasma membrane microdomains and its consequences for mast cell signaling. Heneberg P, et al. Eur J Immunol, 2006 Oct. PMID 17013982
    2. Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis. Kurayama R, et al. Lab Invest, 2011 Jul. PMID 21403644
    3. Regulation of Ca2+ signaling in mast cells by tyrosine-phosphorylated and unphosphorylated non-T cell activation linker. Dráberová L, et al. J Immunol, 2007 Oct 15. PMID 17911602
    4. Induction of inducible nitric oxide synthase expression in ammonia-exposed cultured astrocytes is coupled to increased arginine transport by upregulated y(+)LAT2 transporter. Zielińska M, et al. J Neurochem, 2015 Dec. PMID 26448619
    5. Ammonia Reduces Intracellular Asymmetric Dimethylarginine in Cultured Astrocytes Stimulating Its y⁺LAT2 Carrier-Mediated Loss. Milewski K, et al. Int J Mol Sci, 2017 Nov 2. PMID 29099056, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results suggest that increased asymmetric dimethylarginine (ADMA) efflux mediated by upregulated yLAT2 may be a mechanism by which ammonia interferes with intra-astrocytic (and possibly intra-endothelial cell) ADMA content and subsequently, NO synthesis in both cell types.
      Title: Ammonia Reduces Intracellular Asymmetric Dimethylarginine in Cultured Astrocytes Stimulating Its y⁺LAT2 Carrier-Mediated Loss.
    2. Up-regulation of y(+)LAT2 transporter is coupled with increased inducible nitric oxide synthase (iNOS) expression
      Title: Induction of inducible nitric oxide synthase expression in ammonia-exposed cultured astrocytes is coupled to increased arginine transport by upregulated y(+)LAT2 transporter.
    3. chemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI, tetraspanin CD9, transmembrane adaptor proteins NTAL and LAT, and cytoskeleton-regulatory proteins of the ERM family
      Title: Cross-talk between tetraspanin CD9 and transmembrane adaptor protein non-T cell activation linker (NTAL) in mast cell activation and chemotaxis.
    4. The Saturday night forecast called for possible showers or thunderstorms, with winds of 20 to 26 mph. The expected total rainfall Saturday ranges from six-tenths of an inch to an inch, with more possible in thunderstorms, the weather service said.
      Title: Role of amino acid transporter LAT2 in the activation of mTORC1 pathway and the pathogenesis of crescentic glomerulonephritis.
    5. LAT2 and LAT1 form separate membrane microdomains in rat basophilic leukemia cells.
      Title: Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL.
    6. LAT2 colocalizes with Thy-1 (CD90); their colocalization is enhanced following Thy-1 aggregation.
      Title: Topography of plasma membrane microdomains and its consequences for mast cell signaling.
    7. Regulates Fc epsilon type I (IgE) receptor-mediated signaling at multiple steps and by different mechanisms in mast cells.
      Title: Regulation of Ca2+ signaling in mast cells by tyrosine-phosphorylated and unphosphorylated non-T cell activation linker.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in B cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in B cell activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in B cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in calcium-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response-regulating signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mast cell degranulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane raft ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    linker for activation of T-cells family member 2
    Names
    LAT-2 like
    Williams-Beuren syndrome chromosome region 5 homolog
    Williams-Beuren syndrome chromosome region 5-like protein
    linker for activation of B-cells
    non-T cell activation linker

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173840.2 → NP_776212.2  linker for activation of T-cells family member 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6J0I1
      Related
      ENSRNOP00000031304.5, ENSRNOT00000034629.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      27740647..27754760
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089532.2 → XP_038945460.1  linker for activation of T-cells family member 2 isoform X3

      Conserved Domains (1) summary
      pfam15703
      Location:51 → 103
      LAT2; Linker for activation of T-cells family member 2

    2. XM_039089533.2 → XP_038945461.1  linker for activation of T-cells family member 2 isoform X4

      Conserved Domains (1) summary
      pfam15703
      Location:51 → 103
      LAT2; Linker for activation of T-cells family member 2

    3. XM_017598358.3 → XP_017453847.2  linker for activation of T-cells family member 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZWF7, A6J0I2
      Related
      ENSRNOP00000083189.1, ENSRNOT00000093800.2
      Conserved Domains (1) summary
      pfam15703
      Location:51 → 207
      LAT2; Linker for activation of T-cells family member 2

    4. XM_039089531.2 → XP_038945459.1  linker for activation of T-cells family member 2 isoform X1

      UniProtKB/Swiss-Prot
      Q8CGL2
      Conserved Domains (1) summary
      pfam15703
      Location:51 → 219
      LAT2; Linker for activation of T-cells family member 2

    5. XM_039089534.2 → XP_038945462.1  linker for activation of T-cells family member 2 isoform X5

      Conserved Domains (1) summary
      pfam15703
      Location:1 → 127
      LAT2; Linker for activation of T-cells family member 2

    RNA

    1. XR_005491642.2 RNA Sequence

    2. XR_005491643.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CGL2.1 GenPept UniProtKB/Swiss-Prot:Q8CGL2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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