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    Ccdc51 coiled-coil domain containing 51 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316008, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ccdc51provided by RGD
    Official Full Name
    coiled-coil domain containing 51provided by RGD
    Primary source
    RGD:1311466
    See related
    EnsemblRapid:ENSRNOG00000020688 AllianceGenome:RGD:1311466
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MITOK; RGD1311466
    Summary
    Predicted to enable mitochondrial ATP-gated potassium channel activity. Predicted to be involved in cell volume homeostasis and mitochondrial potassium ion transmembrane transport. Predicted to be located in mitochondrial inner membrane. Predicted to be part of mitochondrial ATP-gated potassium channel complex. Orthologous to human CCDC51 (coiled-coil domain containing 51). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 46.1), Adrenal (RPKM 38.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ccdc51 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (118601002..118619943)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (109722595..109741478)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117812091..117830848)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene three prime repair exonuclease 1 Neighboring gene ATR interacting protein Neighboring gene U2 spliceosomal RNA Neighboring gene translation machinery associated 7 homolog Neighboring gene plexin B1 Neighboring gene cytochrome c oxidase subunit 6C, pseudogene 2 Neighboring gene F-box and WD repeat domain containing 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of an ATP-sensitive potassium channel in mitochondria. Paggio A, et al. Nature, 2019 Aug. PMID 31435016, Free PMC Article
    2. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mitochondrial ATP-gated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mitochondrial ATP-gated potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell volume homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial ATP-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial ATP-gated potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    part_of potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial potassium channel
    Names
    coiled-coil domain-containing protein 51

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014098.2 → NP_001014120.2  mitochondrial potassium channel

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q5PPN7
      UniProtKB/TrEMBL
      A0A8I6GKL1, A6I3B5
      Related
      ENSRNOP00000090082.2, ENSRNOT00000104394.2
      Conserved Domains (1) summary
      TIGR02169
      Location:112 → 264
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      118601002..118619943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243790.5 → XP_006243852.1  mitochondrial potassium channel isoform X2

      UniProtKB/TrEMBL
      A0A0G2JXH2, A0A0H2UHS3
      Conserved Domains (1) summary
      TIGR02169
      Location:131 → 283
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    2. XM_006243791.4 → XP_006243853.1  mitochondrial potassium channel isoform X3

      See identical proteins and their annotated locations for XP_006243853.1

      UniProtKB/Swiss-Prot
      Q5PPN7
      UniProtKB/TrEMBL
      A0A8I6GKL1, A6I3B5
      Related
      ENSRNOP00000070269.2, ENSRNOT00000077228.3
      Conserved Domains (1) summary
      TIGR02169
      Location:112 → 264
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    3. XM_006243789.5 → XP_006243851.1  mitochondrial potassium channel isoform X1

      UniProtKB/TrEMBL
      A0A8I6GKL1
      Related
      ENSRNOP00000094126.2, ENSRNOT00000102638.2
      Conserved Domains (1) summary
      TIGR02169
      Location:143 → 295
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    4. XM_006243792.5 → XP_006243854.1  mitochondrial potassium channel isoform X3

      See identical proteins and their annotated locations for XP_006243854.1

      UniProtKB/Swiss-Prot
      Q5PPN7
      UniProtKB/TrEMBL
      A0A8I6GKL1, A6I3B5
      Conserved Domains (1) summary
      TIGR02169
      Location:112 → 264
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5PPN7.2 GenPept UniProtKB/Swiss-Prot:Q5PPN7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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