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    Dzip1l DAZ interacting zinc finger protein 1-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315952, updated on 10-Oct-2024

    Summary

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    Official Symbol
    Dzip1lprovided by RGD
    Official Full Name
    DAZ interacting zinc finger protein 1-likeprovided by RGD
    Primary source
    RGD:1311430
    See related
    EnsemblRapid:ENSRNOG00000014746 AllianceGenome:RGD:1311430
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311430
    Summary
    Predicted to enable metal ion binding activity. Predicted to be involved in cilium assembly and regulation of protein localization. Predicted to act upstream of or within several processes, including ciliary transition zone assembly; neural tube development; and protein localization to cilium. Predicted to be located in axoneme and centriole. Predicted to be active in ciliary basal body and cytoplasm. Human ortholog(s) of this gene implicated in polycystic kidney disease 5. Orthologous to human DZIP1L (DAZ interacting zinc finger protein 1 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 47.0), Kidney (RPKM 39.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dzip1l in Genome Data Viewer
    Location:
    8q31
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (109067466..109108390)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (100188414..100229077)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (107875659..107916298)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547387 Neighboring gene alpha-1,4-N-acetylglucosaminyltransferase Neighboring gene claudin 18 Neighboring gene uncharacterized LOC134480090 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The Zn finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis. Glazer AM, et al. Dev Biol, 2010 Jan 1. PMID 19852954, Free PMC Article
    2. Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease. Lu H, et al. Nat Genet, 2017 Jul. PMID 28530676, Free PMC Article
    3. Centrosomal protein Dzip1l binds Cby, promotes ciliary bud formation, and acts redundantly with Bromi to regulate ciliogenesis in the mouse. Wang C, et al. Development, 2018 Mar 15. PMID 29487109, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ciliary transition zone assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ciliary transition zone assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in floor plate development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within floor plate development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neural tube patterning IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neural tube patterning ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein localization to cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axoneme IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriole IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ciliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cilium assembly protein DZIP1L
    Names
    DAZ interacting protein 1-like
    DAZ-interacting protein 1-like protein
    zinc finger protein DZIP1L

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001014095.1 → NP_001014117.1  cilium assembly protein DZIP1L

      See identical proteins and their annotated locations for NP_001014117.1

      Status: VALIDATED

      Source sequence(s)
      BC083786
      UniProtKB/Swiss-Prot
      Q5XIA0
      UniProtKB/TrEMBL
      A0A8L2R8N8, A6I2E2
      Related
      ENSRNOP00000019902.6, ENSRNOT00000019902.7
      Conserved Domains (1) summary
      pfam13815
      Location:24 → 144
      Dzip-like_N; Iguana/Dzip1-like DAZ-interacting protein N-terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      109067466..109108390
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006243626.5 → XP_006243688.1  cilium assembly protein DZIP1L isoform X1

      See identical proteins and their annotated locations for XP_006243688.1

      UniProtKB/TrEMBL
      A0A8L2R8N8
      Related
      ENSRNOP00000074346.3, ENSRNOT00000090299.3
      Conserved Domains (1) summary
      pfam13815
      Location:24 → 144
      Dzip-like_N; Iguana/Dzip1-like DAZ-interacting protein N-terminal

    2. XM_063265593.1 → XP_063121663.1  cilium assembly protein DZIP1L isoform X2

      UniProtKB/Swiss-Prot
      Q5XIA0
      UniProtKB/TrEMBL
      A6I2E2

    3. XM_006243627.5 → XP_006243689.1  cilium assembly protein DZIP1L isoform X1

      See identical proteins and their annotated locations for XP_006243689.1

      UniProtKB/TrEMBL
      A0A8L2R8N8
      Conserved Domains (1) summary
      pfam13815
      Location:24 → 144
      Dzip-like_N; Iguana/Dzip1-like DAZ-interacting protein N-terminal

    4. XM_063265594.1 → XP_063121664.1  cilium assembly protein DZIP1L isoform X2

      UniProtKB/Swiss-Prot
      Q5XIA0
      UniProtKB/TrEMBL
      A6I2E2

    RNA

    1. XR_010053982.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIA0.1 GenPept UniProtKB/Swiss-Prot:Q5XIA0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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