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    ctp cut up [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31405, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ctpprovided by FlyBase
    Official Full Name
    cut upprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011760
    Locus tag
    Dmel_CG6998
    See related
    AllianceGenome:FB:FBgn0011760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO03040301.128; Cdlc1; CG6998; Ctp; Ddlc-1; ddlc1; Ddlc1; DdlC1; dDYNLL1; dlc; Dlc; DLC8; Dmel\CG6998; l(1)G0153; l(1)G0204; l(1)G0207; l(1)G0244; l(1)G0248; l(1)G0338; l(1)G0371; l(1)G0387; l(1)G0432; l(1)G0445; LC8; lincRNA.S8635
    Summary
    Enables several functions, including disordered domain specific binding activity; dynein intermediate chain binding activity; and dynein light intermediate chain binding activity. Involved in several processes, including cytoskeleton organization; germ cell development; and piRNA-mediated retrotransposon silencing by heterochromatin formation. Located in centriole and cytoplasm. Part of RNA polymerase II transcription repressor complex and cytoplasmic dynein complex. Is active in cytosol and nucleus. Is expressed in several structures, including cuboidal/columnar epithelium; embryonic/larval midgut primordium; ganglia; germline cell; and head epidermis primordium. Orthologous to several human genes including DYNLL2 (dynein light chain LC8-type 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See ctp in Genome Data Viewer
    Location:
    4C13-4C14; 1-8 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (4687800..4702034)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (4581833..4596067)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene fizzy-related Neighboring gene Protein phosphatase 2C Neighboring gene Pyruvate dehydrogenase E1 alpha subunit Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutations in the 8 kDa dynein light chain gene disrupt sensory axon projections in the Drosophila imaginal CNS. Phillis R, et al. Development, 1996 Oct. PMID 8898210
    2. NMR characterization of structural and dynamics perturbations due to a single point mutation in Drosophila DLC8 dimer: functional implications. Mohan PM, et al. Biochemistry, 2008 Jun 10. PMID 18465876
    3. Dimerization and folding of LC8, a highly conserved light chain of cytoplasmic dynein. Barbar E, et al. Biochemistry, 2001 Feb 13. PMID 11327818
    4. Dynein light chain 1 functions in somatic cyst cells regulate spermatogonial divisions in Drosophila. Joti P, et al. Sci Rep, 2011. PMID 22355688, Free PMC Article
    5. The solution structure of the pH-induced monomer of dynein light-chain LC8 from Drosophila. Makokha M, et al. Protein Sci, 2004 Mar. PMID 14767079, Free PMC Article

    See all (155) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Linker Length Drives Heterogeneity of Multivalent Complexes of Hub Protein LC8 and Transcription Factor ASCIZ.
      Title: Linker Length Drives Heterogeneity of Multivalent Complexes of Hub Protein LC8 and Transcription Factor ASCIZ.
    2. Dimerisation of the PICTS complex via LC8/Cut-up drives co-transcriptional transposon silencing in Drosophila.
      Title: Dimerisation of the PICTS complex via LC8/Cut-up drives co-transcriptional transposon silencing in Drosophila.
    3. Dynein light chain-dependent dimerization of Egalitarian is essential for maintaining oocyte fate in Drosophila.
      Title: Dynein light chain-dependent dimerization of Egalitarian is essential for maintaining oocyte fate in Drosophila.
    4. Genetic and biochemical analyses reveals that the Drosophila homolog of the LC8 dynein light chains (mammalian DYNLL1 and DYNLL2), called Cut up, binds proteasomes and functions specifically during their transport. These data support the model that Cut up functions to specify the dynein-mediated transport of neuronal proteasomes.
      Title: The Drosophila LC8 homolog cut up specifies the axonal transport of proteasomes.
    5. Data suggest that Ctp may interact with a Hippo pathway protein(s) to exert inverse transcriptional effects on Yorkie-target genes.
      Title: Inverse regulation of two classic Hippo pathway target genes in Drosophila by the dimerization hub protein Ctp.
    6. Size exclusion chromatography coupled with multiangle static light scattering demonstrates that LC8 dimers bind Ana2M sites and induce Ana2 tetramerization, yielding an Ana2M4-LC88 complex.
      Title: The mechanism of dynein light chain LC8-mediated oligomerization of the Ana2 centriole duplication factor.
    7. Dynein light chain 1 functions in somatic cyst cells to regulate spermatogonial divisions in Drosophila
      Title: Dynein light chain 1 functions in somatic cyst cells regulate spermatogonial divisions in Drosophila.
    8. these findings reveal that the centrosomal proteins Ana2 and Ctp regulate Mud function to orient the mitotic spindle during neuroblasts asymmetric division.
      Title: An ana2/ctp/mud complex regulates spindle orientation in Drosophila neuroblasts.
    9. LC8 binding promotes IC self-association of helix 1 from each of two IC chains, whereas LC7 binding reverses self-association by incorporating the same residues into two symmetrical, but distant, helices of the LC7-IC complex
      Title: Light chain-dependent self-association of dynein intermediate chain.
    10. Data propose bicoid mRNA localization was done by Swallow indirectly organizing the cytoskeleton, whereas Staufen plays a direct role in dynein-dependent bicoid mRNA transport.
      Title: Distinguishing direct from indirect roles for bicoid mRNA localization factors.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 4688368-4688628 mobile_element_type = transposon:HMS-Beagle{}2418

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables disordered domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein intermediate chain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables dynein light intermediate chain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription corepressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament bundle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chaeta development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chaeta morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule anchoring at centrosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in piRNA-mediated retrotransposon silencing by heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron remodeling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm individualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatid nucleus elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in wing disc development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription repressor complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cytoplasmic dynein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of dynein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cut up
    Names
    8kd dynein light chain
    CG6998-PA
    CG6998-PB
    CG6998-PC
    CG6998-PE
    CG6998-PF
    Cut up
    ctp-PA
    ctp-PB
    ctp-PC
    ctp-PE
    ctp-PF
    cytoplasmic dynein
    cytoplasmic dynein 8kD light chain
    cytoplasmic dynein light chain 1
    dynein
    dynein light chain
    dynein light chain 1
    dynein light chain 8
    dynein light chain LC8
    dynein light-chain
    dynein light-chain 1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      4687800..4702034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167014.3 → NP_726942.1  cut up, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726942.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3Y5, Q24117, Q9V3Y6
      UniProtKB/TrEMBL
      M9NDP1
      Related
      FBpp0070672
      Conserved Domains (1) summary
      cd21452
      Location:5 → 88
      DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family

    2. NM_167015.3 → NP_726943.1  cut up, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726943.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3Y5, Q24117, Q9V3Y6
      UniProtKB/TrEMBL
      M9NDP1
      Related
      FBpp0070675
      Conserved Domains (1) summary
      cd21452
      Location:5 → 88
      DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family

    3. NM_001258601.3 → NP_001245530.1  cut up, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245530.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3Y5, Q24117, Q9V3Y6
      UniProtKB/TrEMBL
      M9NDP1
      Conserved Domains (1) summary
      cd21452
      Location:5 → 88
      DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family

    4. NM_001370042.1 → NP_001356933.1  cut up, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A4D6K1L3
      Conserved Domains (1) summary
      PTZ00059
      Location:1 → 89
      PTZ00059; dynein light chain; Provisional

    5. NM_080336.5 → NP_525075.1  cut up, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525075.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3Y5, Q24117, Q9V3Y6
      UniProtKB/TrEMBL
      M9NDP1
      Related
      FBpp0070674
      Conserved Domains (1) summary
      cd21452
      Location:5 → 88
      DLC-like_DYNLL1_DYNLL2; dynein light chain (DLC)-like domain found in the cytoplasmic dynein light chain 1 (DYNLL1) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A4D6K1L3 A0A4D6K1L3
    M9NDP1 M9NDP1
    Q24117.1 Q24117
    Q8SX77 Q8SX77

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