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    Sec1 secretory blood group 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308586, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Sec1provided by RGD
    Official Full Name
    secretory blood group 1provided by RGD
    Primary source
    RGD:1562499
    See related
    EnsemblRapid:ENSRNOG00000021014 AllianceGenome:RGD:1562499
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ftc; RGD1562499
    Summary
    Predicted to enable galactoside 2-alpha-L-fucosyltransferase activity. Predicted to be involved in fucosylation and protein glycosylation. Predicted to be located in Golgi cisterna membrane. Human ortholog(s) of this gene implicated in vitamin B12 deficiency. Orthologous to human FUT2 (fucosyltransferase 2 (H blood group)). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Testes (RPKM 23.8), Adrenal (RPKM 5.1) and 3 other tissues See more
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    Genomic context

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    See Sec1 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (105287093..105301588, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (96143390..96164249, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101663205..101677016, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene MEF2 activating motif and SAP domain containing transcriptional regulator Neighboring gene fucosyltransferase 2 Neighboring gene netrin 5 Neighboring gene carbonic anhydrase 11 Neighboring gene D-box binding PAR bZIP transcription factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. An amino acid region at the N-terminus of rat hepatoma alpha1-->2 fucosyltransferase modulates enzyme activity and interaction with lipids: strong preference for glycosphingolipids containing terminal Galbeta1-->3GalNAc-structures. Sherwood AL, et al. Biochemistry, 2001 May 15. PMID 11341836
    2. Cloning and expression of the catalytic domain from rat hepatoma H35 cell GDP-fucose:GM1 alpha 1-->2fucosyltransferase, an enzyme which is activated during early stages of chemical carcinogenesis in rat liver. Sherwood AL, et al. Arch Biochem Biophys, 1998 Jul 15. PMID 9675030
    3. Evidence for two distinct alpha(1,2)-fucosyltransferase genes differentially expressed throughout the rat colon. Piau JP, et al. Biochem J, 1994 Jun 15. PMID 8010942, Free PMC Article
    4. Comparison of the three rat GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferases FTA, FTB and FTC. Bureau V, et al. Eur J Biochem, 2001 Feb. PMID 11179967
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables galactoside 2-alpha-L-fucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fucosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    fucosyltransferase 10
    Names
    alpha 1,2-fucosyltransferase C
    NP_001129056.1
    XP_008757601.1
    XP_017444629.1
    XP_017444630.1
    XP_038968114.1
    XP_038968126.1
    XP_038968134.1
    XP_038968138.1
    XP_038968143.1
    XP_038968147.1
    XP_038968163.1
    XP_038968173.1
    XP_063118128.1
    XP_063118150.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135584.1 → NP_001129056.1  fucosyltransferase 10

      See identical proteins and their annotated locations for NP_001129056.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6JB67, Q9WUE6
      Conserved Domains (1) summary
      pfam01531
      Location:1 → 272
      Glyco_transf_11; Glycosyl transferase family 11

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      105287093..105301588 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017589141.3 → XP_017444630.1  fucosyltransferase 10 isoform X1

      UniProtKB/TrEMBL
      F1MAG9
      Conserved Domains (1) summary
      pfam01531
      Location:55 → 362
      Glyco_transf_11; Glycosyl transferase family 11

    2. XM_017589140.3 → XP_017444629.1  fucosyltransferase 10 isoform X1

      UniProtKB/TrEMBL
      F1MAG9
      Related
      ENSRNOP00000028522.6, ENSRNOT00000028522.9
      Conserved Domains (1) summary
      pfam01531
      Location:55 → 362
      Glyco_transf_11; Glycosyl transferase family 11

    3. XM_039112235.2 → XP_038968163.1  fucosyltransferase 10 isoform X2

      UniProtKB/TrEMBL
      A6JB67, Q9WUE6
      Conserved Domains (1) summary
      pfam01531
      Location:1 → 272
      Glyco_transf_11; Glycosyl transferase family 11

    4. XM_039112210.2 → XP_038968138.1  fucosyltransferase 10 isoform X2

      UniProtKB/TrEMBL
      A6JB67, Q9WUE6
      Conserved Domains (1) summary
      pfam01531
      Location:1 → 272
      Glyco_transf_11; Glycosyl transferase family 11

    5. XM_039112186.2 → XP_038968114.1  fucosyltransferase 10 isoform X1

      UniProtKB/TrEMBL
      F1MAG9
      Conserved Domains (1) summary
      pfam01531
      Location:55 → 362
      Glyco_transf_11; Glycosyl transferase family 11

    6. XM_008759379.4 → XP_008757601.1  fucosyltransferase 10 isoform X2

      See identical proteins and their annotated locations for XP_008757601.1

      UniProtKB/TrEMBL
      A6JB67, Q9WUE6
      Conserved Domains (1) summary
      pfam01531
      Location:1 → 272
      Glyco_transf_11; Glycosyl transferase family 11

    7. XM_039112245.2 → XP_038968173.1  fucosyltransferase 10 isoform X2

      UniProtKB/TrEMBL
      A6JB67, Q9WUE6
      Conserved Domains (1) summary
      pfam01531
      Location:1 → 272
      Glyco_transf_11; Glycosyl transferase family 11

    8. XM_039112219.2 → XP_038968147.1  fucosyltransferase 10 isoform X2

      UniProtKB/TrEMBL
      A6JB67, Q9WUE6
      Conserved Domains (1) summary
      pfam01531
      Location:1 → 272
      Glyco_transf_11; Glycosyl transferase family 11

    9. XM_039112206.2 → XP_038968134.1  fucosyltransferase 10 isoform X2

      UniProtKB/TrEMBL
      A6JB67, Q9WUE6
      Conserved Domains (1) summary
      pfam01531
      Location:1 → 272
      Glyco_transf_11; Glycosyl transferase family 11

    10. XM_063262080.1 → XP_063118150.1  fucosyltransferase 10 isoform X2

      UniProtKB/TrEMBL
      A6JB67

    11. XM_039112215.2 → XP_038968143.1  fucosyltransferase 10 isoform X2

      UniProtKB/TrEMBL
      A6JB67, Q9WUE6
      Conserved Domains (1) summary
      pfam01531
      Location:1 → 272
      Glyco_transf_11; Glycosyl transferase family 11

    12. XM_063262058.1 → XP_063118128.1  fucosyltransferase 10 isoform X1

      UniProtKB/TrEMBL
      F1MAG9

    13. XM_039112198.2 → XP_038968126.1  fucosyltransferase 10 isoform X1

      UniProtKB/TrEMBL
      F1MAG9
      Conserved Domains (1) summary
      pfam01531
      Location:55 → 362
      Glyco_transf_11; Glycosyl transferase family 11
    Nucleotide Protein Strain
    Heading Accession and Version

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