Egln2 egl-9 family hypoxia-inducible factor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Egln2provided by RGD
Official Full Name: egl-9 family hypoxia-inducible factor 2provided by RGD
Primary source: RGD:631376
See related: EnsemblRapid:ENSRNOG00000020947 AllianceGenome:RGD:631376
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PHD1; HPH-1; HPH-3; PHD-1; HIF-PH1
Summary: Enables peptidyl-proline 4-dioxygenase activity. Involved in peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human EGLN2 (egl-9 family hypoxia inducible factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 213.7), Testes (RPKM 198.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (91579205..91586985, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (82451554..82459809, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (83969456..83977665, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA MIAT enhances cerebral ischaemia/reperfusion injury in rat model via interacting with EGLN2 and reduces its ubiquitin-mediated degradation.
Title: LncRNA MIAT enhances cerebral ischaemia/reperfusion injury in rat model via interacting with EGLN2 and reduces its ubiquitin-mediated degradation.
that combined function of HIF-1alpha and FoxO3a under high glucose plus hypoxia condition lead to enhanced expression of BNIP3 inducing cardiomyocyte death
Title: Synergistic effect of HIF-1α and FoxO3a trigger cardiomyocyte apoptosis under hyperglycemic ischemia condition.
In conclusion, a low-level laser could modulate HIF-1alpha activity in nerve entrapment neuropathy
Title: Low-level laser therapy alleviates neuropathic pain and promotes function recovery in rats with chronic constriction injury: possible involvements in hypoxia-inducible factor 1α (HIF-1α).
HIF-1alpha is overexpressed for 14 days after somatic gene transfer in adult rats, and a slow-to-fast transformation is observed in muscle fibers.
Title: Hypoxia inducible factor 1 links fast-patterned muscle activity and fast muscle phenotype in rats.
Report increased prolyl 4-hydroxylase expression and differential regulation of hypoxia-inducible factors in the aged rat brain.
Title: Increased prolyl 4-hydroxylase expression and differential regulation of hypoxia-inducible factors in the aged rat brain.
HIF-1alpha may be involved in the protective effect of preceding hypoxia on ischemia/reperfusion injury in the right ventricle
Title: Protection of the right ventricle from ischemia and reperfusion by preceding hypoxia.
Increased mTOR-dependent HIF-1alpha synthesis and decreased hydroxylase-dependent HIF-1alpha degradation contribute to intermittent hypoxia-evoked HIF-1alpha accumulation.
Title: Induction of HIF-1alpha expression by intermittent hypoxia: involvement of NADPH oxidase, Ca2+ signaling, prolyl hydroxylases, and mTOR.
identified the three forms of prolyl hydroxylase in rats and demonstrated that a period of hypoxia selectively increases expression of PHD-2 mRNAs levels
Title: Hypoxia up-regulates prolyl hydroxylase activity: a feedback mechanism that limits HIF-1 responses during reoxygenation.

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General gene information

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Markers

RH125240 (e-PCR)
- UniSTS:162062

BF418972 (e-PCR)
- UniSTS:243432

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 2-oxoglutarate-dependent dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables L-ascorbic acid binding	IEA Inferred from Electronic Annotation more info
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables ferrous iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables ferrous iron binding	ISO Inferred from Sequence Orthology more info
enables ferrous iron binding	ISS Inferred from Sequence or Structural Similarity more info
enables hypoxia-inducible factor-proline dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxygen sensor activity	ISO Inferred from Sequence Orthology more info
enables peptidyl-proline 4-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-proline 4-dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidyl-proline 4-dioxygenase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to hypoxia	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-proline hydroxylation to 4-hydroxy-L-proline	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to hypoxia	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: prolyl hydroxylase EGLN2

Names: HIF-1alpha prolyl-4-hydroxylase-1; HIF-prolyl hydroxylase 1; hypoxia-inducible factor prolyl hydroxylase 1; prolyl hydroxylase domain-containing protein 1

NP_001004083.1

EC 1.14.11.29

XP_038967457.1

EC 1.14.11.29

XP_038967464.1

EC 1.14.11.29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004083.1 → NP_001004083.1 prolyl hydroxylase EGLN2

See identical proteins and their annotated locations for NP_001004083.1

Status: PROVISIONAL

Source sequence(s)

BC078907

UniProtKB/Swiss-Prot

Q6AYU4

Related

ENSRNOP00000028434.4, ENSRNOT00000028434.8

Conserved Domains (1) summary

smart00702
Location:213 → 383

P4Hc; Prolyl 4-hydroxylase alpha subunit homologues

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

91579205..91586985 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111529.2 → XP_038967457.1 prolyl hydroxylase EGLN2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZS56

Related

ENSRNOP00000081509.1, ENSRNOT00000116136.2

Conserved Domains (1) summary

smart00702
Location:329 → 438

P4Hc; Prolyl 4-hydroxylase alpha subunit homologues
XM_039111536.1 → XP_038967464.1 prolyl hydroxylase EGLN2 isoform X2

UniProtKB/TrEMBL

A6J9B3

Conserved Domains (1) summary

smart00702
Location:3 → 97

P4Hc; Prolyl 4-hydroxylase alpha subunit homologues