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    Tcp10b t-complex protein 10b [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308169, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Tcp10bprovided by RGD
    Official Full Name
    t-complex protein 10bprovided by RGD
    Primary source
    RGD:1307454
    See related
    EnsemblRapid:ENSRNOG00000013374 AllianceGenome:RGD:1307454
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of transcription, DNA-templated. Predicted to be active in centriole and nucleus. Orthologous to several human genes including TCP10L2 (t-complex 10 like 2, pseudogene). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 1047.2) See more
    Orthologs
    human all
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    Genomic context

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    See Tcp10b in Genome Data Viewer
    Location:
    1q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (55485354..55508836)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (52937823..52961307)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (53530992..53554113)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small Cajal body-specific RNA 3 Neighboring gene ribosomal protein S6 kinase A2 Neighboring gene uncharacterized LOC134482724 Neighboring gene G protein-coupled receptor 31 Neighboring gene uncharacterized LOC134482726 Neighboring gene tubulin tyrosine ligase like 2 Neighboring gene unc-93 homolog A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of TCP10L as primate-specific gene derived via segmental duplication and homodimerization of TCP10L through the leucine zipper motif. Zhong Z, et al. Mol Biol Rep, 2008 Jun. PMID 17377852
    2. Identification of a novel liver-specific expressed gene, TCP10L, encoding a human leucine zipper protein with transcription inhibition activity. Chen Z, et al. J Hum Genet, 2003. PMID 14586771
    3. Human liver specific transcriptional factor TCP10L binds to MAD4. Jiang DJ, et al. J Biochem Mol Biol, 2004 Jul 31. PMID 15469726
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    T-complex protein 10A homolog 2
    Names
    putative t-complex protein 10A homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001412638.1 → NP_001399567.1  T-complex protein 10A homolog 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2JYT7, A6KK47, B2GUX1, D3ZUW1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      55485354..55508836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008758759.3 → XP_008756981.1  T-complex protein 10A homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYT7, A6KK47
      Conserved Domains (1) summary
      pfam07202
      Location:306 → 513
      Tcp10_C; T-complex protein 10 C-terminus

    2. XM_017589093.2 → XP_017444582.1  T-complex protein 10A homolog 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2JYT7, A6KK47
      Related
      ENSRNOP00000102497.1, ENSRNOT00000143938.1

    3. XM_008758757.3 → XP_008756979.1  T-complex protein 10A homolog 2 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JYT7, A6KK47
      Related
      ENSRNOP00000087403.2, ENSRNOT00000109422.2
      Conserved Domains (1) summary
      pfam07202
      Location:306 → 479
      Tcp10_C; T-complex protein 10 C-terminus

    4. XM_008758758.3 → XP_008756980.1  T-complex protein 10A homolog 2 isoform X7

      UniProtKB/TrEMBL
      A0A0G2JYT7, A6KK47
      Related
      ENSRNOP00000018015.7, ENSRNOT00000018015.9
      Conserved Domains (1) summary
      pfam07202
      Location:305 → 432
      Tcp10_C; T-complex protein 10 C-terminus

    5. XM_006227927.4 → XP_006227989.1  T-complex protein 10A homolog 2 isoform X4

      UniProtKB/TrEMBL
      A0A0G2JYT7, A6KK47
      Conserved Domains (2) summary
      pfam04012
      Location:15 → 120
      PspA_IM30; PspA/IM30 family
      pfam07202
      Location:265 → 472
      Tcp10_C; T-complex protein 10 C-terminus

    6. XM_063288520.1 → XP_063144590.1  T-complex protein 10A homolog 2 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JYT7, A6KK47

    7. XM_006227928.5 → XP_006227990.1  T-complex protein 10A homolog 2 isoform X6

      UniProtKB/TrEMBL
      A0A0G2JYT7, A0A8I6A4A8, A6KK47
      Conserved Domains (2) summary
      pfam04012
      Location:15 → 120
      PspA_IM30; PspA/IM30 family
      pfam07202
      Location:265 → 438
      Tcp10_C; T-complex protein 10 C-terminus

    8. XM_063288521.1 → XP_063144591.1  T-complex protein 10A homolog 2 isoform X8

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107461.1: Suppressed sequence

      Description
      NM_001107461.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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