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    US27 envelope glycoprotein US27 [ Human betaherpesvirus 5 ]

    Gene ID: 3077557, updated on 18-Aug-2023

    Summary

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    Gene symbol
    US27
    Gene description
    envelope glycoprotein US27
    Locus tag
    HHV5wtgp157
    Gene type
    protein coding
    RNA name
    envelope glycoprotein US27
    RefSeq status
    PROVISIONAL
    Organism
    Human betaherpesvirus 5 (strain: Merlin, acronym: HHV-5; HCMV, nat-host: Homo sapiens, culture-collection: ATCC:VR-1590)
    Lineage
    Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus
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    Genomic context

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    Sequence:
    NC_006273.2 (223800..226529)

    NC_006273.2Genomic Context describing neighboring genes Neighboring gene tegument protein US24 Neighboring gene protein US26 Neighboring gene envelope protein US28 Neighboring gene membrane protein US29 Neighboring gene membrane protein US30 Neighboring gene protein US31

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_006273.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The human cytomegalovirus chemokine receptor homolog encoded by US27. Stegman JR, et al. Virus Genes, 2017 Aug. PMID 28447191
    2. The human cytomegalovirus US27 gene product enhances cell proliferation and alters cellular gene expression. Lares AP, et al. Virus Res, 2013 Sep. PMID 23850869, Free PMC Article
    3. Receptor chimeras demonstrate that the C-terminal domain of the human cytomegalovirus US27 gene product is necessary and sufficient for intracellular receptor localization. Stapleton LK, et al. Virol J, 2012 Feb 16. PMID 22339884, Free PMC Article
    4. Human cytomegalovirus pUS27 G protein-coupled receptor homologue is required for efficient spread by the extracellular route but not for direct cell-to-cell spread. O'Connor CM, et al. J Virol, 2011 Apr. PMID 21307184, Free PMC Article
    5. Intracellular trafficking of the human cytomegalovirus-encoded 7-trans-membrane protein homologs pUS27 and pUL78 during viral infection: a comparative analysis. Niemann I, et al. Viruses, 2014 Feb 10. PMID 24517969, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Identification of a novel signaling complex containing host chemokine receptor CXCR4, Interleukin-10 receptor, and human cytomegalovirus US27.
      Title: Identification of a novel signaling complex containing host chemokine receptor CXCR4, Interleukin-10 receptor, and human cytomegalovirus US27.
    2. US27 expression enhance HCMV infection by prolonging host cell survival and proliferation.[review]
      Title: The human cytomegalovirus chemokine receptor homolog encoded by US27.
    3. Most importantly, infection experiments with a recombinant human cytomegalovirus carrying tagged versions of pUS27 and pUL78 simultaneously, revealed that these two proteins do not colocalize during viral infection.
      Title: Intracellular trafficking of the human cytomegalovirus-encoded 7-trans-membrane protein homologs pUS27 and pUL78 during viral infection: a comparative analysis.
    4. These results demonstrate that US27 can impact host cell physiology and may shed light on the function of this orphan viral G protein-coupled receptor.
      Title: The human cytomegalovirus US27 gene product enhances cell proliferation and alters cellular gene expression.
    5. Potentiation of CXCR4 signaling by US27 could represent a novel strategy by which human cytomegalovirus targets virus-infected cells to the bone marrow in order to expand the reservoir of latently infected cells.
      Title: The US27 gene product of human cytomegalovirus enhances signaling of host chemokine receptor CXCR4.
    6. The results indicate that the C-terminal domain of the HCMV US27 protein, which contains a di-leucine endocytic sorting motif, is both necessary and sufficient for intracellular localization.
      Title: Receptor chimeras demonstrate that the C-terminal domain of the human cytomegalovirus US27 gene product is necessary and sufficient for intracellular receptor localization.
    7. The authors conclude that pUS27 acts at a late stage of the human cytomegalovirus replication cycle to support spread of virus by the extracellular route.
      Title: Human cytomegalovirus pUS27 G protein-coupled receptor homologue is required for efficient spread by the extracellular route but not for direct cell-to-cell spread.
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    Pathways from PubChem

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    General gene information

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    Homology

    regulatory

    • Loc: 223800-223805 regulatory_class = TATA_box
    • Loc: 226498-226503 regulatory_class = polyA_signal_sequence

    General protein information

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    Preferred Names
    envelope glycoprotein US27
    YP_081611.1
    • GPCR family

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_006273.2 Reference assembly

      Range
      223800..226529
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_081611.1 envelope glycoprotein US27 [Human betaherpesvirus 5]

      See identical proteins and their annotated locations for YP_081611.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      F5HDK1
      UniProtKB/TrEMBL
      A0A1D6WRH8, D2K3X1, Q0PQ24, Q6SVY0
      Conserved Domains (1) summary
      pfam00001
      Location:50 → 296
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    Nucleotide Protein
    Heading Accession and Version

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