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    Map2k3 mitogen activated protein kinase kinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 303200, updated on 2-Nov-2024

    Summary

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    Symbol
    Map2k3provided by RGD
    Full Name
    mitogen activated protein kinase kinase 3provided by RGD
    Primary source
    RGD:1306620
    See related
    EnsemblRapid:ENSRNOG00000065992 AllianceGenome:RGD:1306620
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mek3; Mkk3
    Summary
    Predicted to enable MAP kinase kinase activity and protein kinase binding activity. Involved in several processes, including cellular response to sorbitol; positive regulation of macromolecule metabolic process; and response to ischemia. Used to study retinal disease. Human ortholog(s) of this gene implicated in cervical cancer and restrictive cardiomyopathy. Orthologous to human MAP2K3 (mitogen-activated protein kinase kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 210.1), Spleen (RPKM 164.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Map2k3 in Genome Data Viewer
    Location:
    10q22
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (46107639..46128986)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (45608145..45629492)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (45089455..45110802)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102546946 Neighboring gene N-acetyltransferase domain containing 1 Neighboring gene mitogen-activated protein kinase kinase 3, opposite strand Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 12 Neighboring gene SRA stem-loop interacting RNA binding protein, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MKK3 depletion attenuates intestinal injury after traumatic hemorrhagic shock by restoring mitochondrial function. Li L, et al. Mol Biol Rep, 2024 Jun 21. PMID 38904879
    2. Matrine-Type Alkaloids Inhibit Advanced Glycation End Products Induced Reactive Oxygen Species-Mediated Apoptosis of Aortic Endothelial Cells In Vivo and In Vitro by Targeting MKK3 and p38MAPK Signaling. Liu Z, et al. J Am Heart Assoc, 2017 Dec 2. PMID 29197828, Free PMC Article
    3. MAPK kinase 3 is a tumor suppressor with reduced copy number in breast cancer. MacNeil AJ, et al. Cancer Res, 2014 Jan 1. PMID 24233520
    4. Lipopolysaccharide induces CYP2E1 in astrocytes through MAP kinase kinase-3 and C/EBPbeta and -delta. Kelicen P, et al. J Biol Chem, 2004 Apr 16. PMID 14670949
    5. Nonparticipation of nuclear factor kappa B (NFkappaB) in the signaling cascade of c-Jun N-terminal kinase (JNK)- and p38 mitogen-activated protein kinase (p38MAPK)-dependent tumor necrosis factor alpha (TNFalpha) induction in lipopolysaccharide (LPS)-stimulated microglia. Uesugi M, et al. Brain Res, 2006 Feb 16. PMID 16457791

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MKK3 depletion attenuates intestinal injury after traumatic hemorrhagic shock by restoring mitochondrial function.
      Title: MKK3 depletion attenuates intestinal injury after traumatic hemorrhagic shock by restoring mitochondrial function.
    2. Matrine-type alkaloids exert endothelial protective effects against advanced glycation end products induced reactive oxygen species-mediated apoptosis by targeting MKK3/6/p38MAPK signaling and enhancing their phosphorylation.
      Title: Matrine-Type Alkaloids Inhibit Advanced Glycation End Products Induced Reactive Oxygen Species-Mediated Apoptosis of Aortic Endothelial Cells In Vivo and In Vitro by Targeting MKK3 and p38MAPK Signaling.
    3. Data suggest that Mapk14/p38alpha is activated and forms cystine disulfide-bound heterodimer with Map2k3/Mkk3 in cardiomyocytes and isolated hearts during oxidative stress (exposure to hydrogen peroxide). (Mapk14, mitogen-activated protein kinase 14; Mkk3 = mitogen-activated protein kinase kinase 3)
      Title: Redox-dependent dimerization of p38α mitogen-activated protein kinase with mitogen-activated protein kinase kinase 3.
    4. Superoxide anion is an important signaling molecule for activating the MKK3/6-p38 cascade, which is requisite for inducing tumor necrosis factor (TNF)alpha in microglia.
      Title: Superoxide anion contributes to the induction of tumor necrosis factor alpha (TNFα) through activation of the MKK3/6-p38 MAPK cascade in rat microglia.
    5. Rap1, MKK3/6, and p38 MAPK have a role in the induction of mGluR-dependent LTD by directly coupling to receptor trafficking machineries to facilitate the loss of synaptic AMPA receptors [map2k3, also called MKK3]
      Title: Rap1-induced p38 mitogen-activated protein kinase activation facilitates AMPA receptor trafficking via the GDI.Rab5 complex. Potential role in (S)-3,5-dihydroxyphenylglycene-induced long term depression.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables MAP kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cellular response to sorbitol IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to vascular endothelial growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heart development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of hippo signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of nitric-oxide synthase biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to ischemia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in stress-activated protein kinase signaling cascade ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dual specificity mitogen-activated protein kinase kinase 3
    Names
    dual specificity mitogen-activated protein kinase kinase 3-like
    NP_001094144.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100674.1 → NP_001094144.1  dual specificity mitogen-activated protein kinase kinase 3

      See identical proteins and their annotated locations for NP_001094144.1

      Status: VALIDATED

      Source sequence(s)
      BC100095, BC160839, DY311082
      UniProtKB/TrEMBL
      B1H230, F7EXM7
      Related
      ENSRNOP00000065373.2, ENSRNOT00000073792.4
      Conserved Domains (2) summary
      cd06617
      Location:62 → 344
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
      smart00220
      Location:67 → 325
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      46107639..46128986
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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