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    Srrm2 serine/arginine repetitive matrix 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302969, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Srrm2provided by RGD
    Official Full Name
    serine/arginine repetitive matrix 2provided by RGD
    Primary source
    RGD:1310163
    See related
    EnsemblRapid:ENSRNOG00000058561 AllianceGenome:RGD:1310163
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable C2H2 zinc finger domain binding activity and mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in Cajal body and nuclear speck. Predicted to be part of U2-type catalytic step 2 spliceosome and U2-type precatalytic spliceosome. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human SRRM2 (serine/arginine repetitive matrix 2). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Adrenal (RPKM 868.1), Kidney (RPKM 521.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Srrm2 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (13320059..13353337)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (12815471..12848750)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (13128820..13162956)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene FLYWCH-type zinc finger 1 Neighboring gene FLYWCH family member 2 Neighboring gene uncharacterized LOC134480759 Neighboring gene elongin B Neighboring gene serine protease 33

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. SRRM2, a potential blood biomarker revealing high alternative splicing in Parkinson's disease. Shehadeh LA, et al. PLoS One, 2010 Feb 8. PMID 20161708, Free PMC Article
    2. Structure and Conformational Dynamics of the Human Spliceosomal B(act) Complex. Haselbach D, et al. Cell, 2018 Jan 25. PMID 29361316
    3. The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing. Miele A, et al. J Cell Biochem, 2007 Sep 1. PMID 17577209
    4. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, et al. Nucleic Acids Res, 2007. PMID 17537823, Free PMC Article
    5. Cryo-EM structure of a human spliceosome activated for step 2 of splicing. Bertram K, et al. Nature, 2017 Feb 16. PMID 28076346

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables C2H2 zinc finger domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/arginine repetitive matrix protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277154.1 → NP_001264083.1  serine/arginine repetitive matrix protein 2

      Status: VALIDATED

      Source sequence(s)
      BC166455, JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6A0A2
      Related
      ENSRNOP00000086062.2, ENSRNOT00000116530.2
      Conserved Domains (3) summary
      PHA03247
      Location:1985 → 2442
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:292 → 609
      PHA03307; transcriptional regulator ICP4; Provisional
      cd21375
      Location:39 → 102
      cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      13320059..13353337
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268912.1 → XP_063124982.1  serine/arginine repetitive matrix protein 2 isoform X1

    2. XM_039085853.2 → XP_038941781.1  serine/arginine repetitive matrix protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A0A2
      Conserved Domains (3) summary
      PHA03247
      Location:1985 → 2442
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:292 → 609
      PHA03307; transcriptional regulator ICP4; Provisional
      cd21375
      Location:39 → 102
      cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

    3. XM_039085854.2 → XP_038941782.1  serine/arginine repetitive matrix protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A0A2
      Conserved Domains (3) summary
      PHA03247
      Location:1984 → 2441
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:291 → 608
      PHA03307; transcriptional regulator ICP4; Provisional
      cd21375
      Location:39 → 102
      cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

    4. XM_063268913.1 → XP_063124983.1  serine/arginine repetitive matrix protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A2Y2
      Related
      ENSRNOP00000083591.2, ENSRNOT00000100880.2

    5. XM_063268914.1 → XP_063124984.1  serine/arginine repetitive matrix protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6G2I7
      Related
      ENSRNOP00000078271.1, ENSRNOT00000116501.2

    6. XM_039085856.2 → XP_038941784.1  serine/arginine repetitive matrix protein 2 isoform X6

      Conserved Domains (1) summary
      cd21375
      Location:39 → 102
      cwf21_SRRM2; cwf21 domain found in serine/arginine repetitive matrix protein 2

    7. XM_039085855.2 → XP_038941783.1  serine/arginine repetitive matrix protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A0A2
      Conserved Domains (2) summary
      PHA03247
      Location:1889 → 2346
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:196 → 513
      PHA03307; transcriptional regulator ICP4; Provisional

    8. XM_063268915.1 → XP_063124985.1  serine/arginine repetitive matrix protein 2 isoform X7

      UniProtKB/TrEMBL
      A6HCM7

    RNA

    1. XR_005489792.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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