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    Bcorl1 BCL6 co-repressor-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302810, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Bcorl1provided by RGD
    Official Full Name
    BCL6 co-repressor-like 1provided by RGD
    Primary source
    RGD:1566108
    See related
    EnsemblRapid:ENSRNOG00000005076 AllianceGenome:RGD:1566108
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1566108
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Shukla-Vernon syndrome. Orthologous to human BCORL1 (BCL6 corepressor like 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 38.3), Lung (RPKM 30.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bcorl1 in Genome Data Viewer
    Location:
    Xq36
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (132394703..132462414)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (127516504..127584529)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (135187468..135233859)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene UTP14A small subunit processome component Neighboring gene U6 spliceosomal RNA Neighboring gene NADH:ubiquinone oxidoreductase subunit B4, pseudogene 3 Neighboring gene E74 like ETS transcription factor 4 Neighboring gene apoptosis inducing factor, mitochondria associated 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. MicroRNA-876-5p inhibits epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma by targeting BCL6 corepressor like 1. Xu Q, et al. Biomed Pharmacother, 2018 Jul. PMID 29679906
    2. [Expression and clinical significance of BCL6 corepressor-like 1 in non-small cell lung cancer]. Zhao X, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2015 Dec. PMID 26648304
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    BCL-6 corepressor-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191587.1 → NP_001178516.1  BCL-6 corepressor-like protein 1

      See identical proteins and their annotated locations for NP_001178516.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      F1LYC7
      Related
      ENSRNOP00000006805.6, ENSRNOT00000006805.9
      Conserved Domains (4) summary
      PHA03247
      Location:201 → 636
      PHA03247; large tegument protein UL36; Provisional
      cd14260
      Location:1669 → 1782
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      sd00045
      Location:1501 → 1532
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1505 → 1596
      Ank_2; Ankyrin repeats (3 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      132394703..132462414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099670.2 → XP_038955598.1  BCL-6 corepressor-like protein 1 isoform X1

      UniProtKB/TrEMBL
      F1LYC7
      Conserved Domains (4) summary
      PHA03247
      Location:201 → 636
      PHA03247; large tegument protein UL36; Provisional
      cd14260
      Location:1669 → 1782
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      sd00045
      Location:1501 → 1532
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1505 → 1596
      Ank_2; Ankyrin repeats (3 copies)

    2. XM_039099669.2 → XP_038955597.1  BCL-6 corepressor-like protein 1 isoform X1

      UniProtKB/TrEMBL
      F1LYC7
      Conserved Domains (4) summary
      PHA03247
      Location:201 → 636
      PHA03247; large tegument protein UL36; Provisional
      cd14260
      Location:1669 → 1782
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      sd00045
      Location:1501 → 1532
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1505 → 1596
      Ank_2; Ankyrin repeats (3 copies)

    3. XM_039099671.2 → XP_038955599.1  BCL-6 corepressor-like protein 1 isoform X1

      UniProtKB/TrEMBL
      F1LYC7
      Conserved Domains (4) summary
      PHA03247
      Location:201 → 636
      PHA03247; large tegument protein UL36; Provisional
      cd14260
      Location:1669 → 1782
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      sd00045
      Location:1501 → 1532
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1505 → 1596
      Ank_2; Ankyrin repeats (3 copies)

    4. XM_039099672.2 → XP_038955600.1  BCL-6 corepressor-like protein 1 isoform X1

      UniProtKB/TrEMBL
      F1LYC7
      Conserved Domains (4) summary
      PHA03247
      Location:201 → 636
      PHA03247; large tegument protein UL36; Provisional
      cd14260
      Location:1669 → 1782
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      sd00045
      Location:1501 → 1532
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1505 → 1596
      Ank_2; Ankyrin repeats (3 copies)

    5. XM_039099673.2 → XP_038955601.1  BCL-6 corepressor-like protein 1 isoform X1

      UniProtKB/TrEMBL
      F1LYC7
      Conserved Domains (4) summary
      PHA03247
      Location:201 → 636
      PHA03247; large tegument protein UL36; Provisional
      cd14260
      Location:1669 → 1782
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      sd00045
      Location:1501 → 1532
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1505 → 1596
      Ank_2; Ankyrin repeats (3 copies)

    6. XM_039099674.2 → XP_038955602.1  BCL-6 corepressor-like protein 1 isoform X1

      UniProtKB/TrEMBL
      F1LYC7
      Conserved Domains (4) summary
      PHA03247
      Location:201 → 636
      PHA03247; large tegument protein UL36; Provisional
      cd14260
      Location:1669 → 1782
      PUFD_like_1; PCGF Ub-like fold discriminator of BCOR-like 1
      sd00045
      Location:1501 → 1532
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:1505 → 1596
      Ank_2; Ankyrin repeats (3 copies)
    Nucleotide Protein Strain
    Heading Accession and Version

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