Farsb phenylalanyl-tRNA synthetase subunit beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Farsbprovided by RGD
Official Full Name: phenylalanyl-tRNA synthetase subunit betaprovided by RGD
Primary source: RGD:1303210
See related: EnsemblRapid:ENSRNOG00000014119 AllianceGenome:RGD:1303210
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Farslb
Summary: Predicted to enable ATP binding activity; RNA binding activity; and magnesium ion binding activity. Predicted to contribute to phenylalanine-tRNA ligase activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation and protein heterotetramerization. Predicted to be part of phenylalanine-tRNA ligase complex. Orthologous to human FARSB (phenylalanyl-tRNA synthetase subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 144.5), Adrenal (RPKM 142.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q33

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (87336321..87395546, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (79887852..79947082, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (84324456..84383674, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BE117296 (e-PCR)
- UniSTS:248661

RH134923 (e-PCR)
- UniSTS:218200

RH139517 (e-PCR)
- UniSTS:221603

RH134502 (e-PCR)
- UniSTS:217782

RH140352 (e-PCR)
- UniSTS:222428

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
contributes_to phenylalanine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phenylalanine-tRNA ligase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in phenylalanyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phenylalanyl-tRNA aminoacylation	ISO Inferred from Sequence Orthology more info
involved_in protein heterotetramerization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of phenylalanine-tRNA ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of phenylalanine-tRNA ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phenylalanine--tRNA ligase beta subunit

Names: phenylalanine-tRNA synthetase-like, beta subunit; phenylalanyl-tRNA synthetase beta chain; phenylalanyl-tRNA synthetase, beta subunit

NP_001004252.1

EC 6.1.1.20

XP_006245251.1

EC 6.1.1.20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001004252.1 → NP_001004252.1 phenylalanine--tRNA ligase beta subunit

See identical proteins and their annotated locations for NP_001004252.1

Status: PROVISIONAL

Source sequence(s)

BC079364

UniProtKB/TrEMBL

F7FM91, Q68FT7

Related

ENSRNOP00000019685.5, ENSRNOT00000019685.7

Conserved Domains (4) summary

smart00873
Location:118 → 279

B3_4; B3/4 domain

PLN02265
Location:1 → 589

PLN02265; probable phenylalanyl-tRNA synthetase beta chain

cd00769
Location:392 → 588

PheRS_beta_core; Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an ...

pfam03484
Location:310 → 374

B5; tRNA synthetase B5 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086027.1 Reference GRCr8

Range

87336321..87395546 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006245189.5 → XP_006245251.1 phenylalanine--tRNA ligase beta subunit isoform X1

UniProtKB/TrEMBL

A0A8I6ATG0

Related

ENSRNOP00000097872.2, ENSRNOT00000118347.2

Conserved Domains (4) summary

smart00873
Location:118 → 279

B3_4; B3/4 domain

PLN02265
Location:1 → 541

PLN02265; probable phenylalanyl-tRNA synthetase beta chain

pfam03484
Location:310 → 374

B5; tRNA synthetase B5 domain

cl00268
Location:392 → 522

class_II_aaRS-like_core; Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches ...