U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Nnmt nicotinamide N-methyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300691, updated on 17-Aug-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Nnmtprovided by RGD
    Official Full Name
    nicotinamide N-methyltransferaseprovided by RGD
    Primary source
    RGD:1309606
    See related
    EnsemblRapid:ENSRNOG00000005930 AllianceGenome:RGD:1309606
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable nicotinamide N-methyltransferase activity. Involved in animal organ regeneration; response to organonitrogen compound; and response to xenobiotic stimulus. Predicted to be active in cytosol. Orthologous to human NNMT (nicotinamide N-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 45.2), Adrenal (RPKM 26.5) and 8 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Nnmt in Genome Data Viewer
    Location:
    8q23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (57820156..57851301, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (48928663..48947734, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (52918437..52938172, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 11 open reading frame 71 Neighboring gene RNA binding motif protein 7 Neighboring gene uncharacterized LOC120094143 Neighboring gene zinc finger and BTB domain containing 16 Neighboring gene uncharacterized LOC120094144 Neighboring gene uncharacterized LOC134480046

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Effect of orally administered phenethyl isothiocyanate on hepatic gene expression in rats. Telang U, et al. Mol Nutr Food Res, 2010 Dec. PMID 20626002, Free PMC Article
    2. Identification of nicotinamide N-methyltransferase as a novel tumor marker for renal clear cell carcinoma. Sartini D, et al. J Urol, 2006 Nov. PMID 17070307
    3. Nicotinamide homeostasis: a xenobiotic pathway that is key to development and degenerative diseases. Williams AC, et al. Med Hypotheses, 2005. PMID 15922112
    4. Increase of nicotinamide methyltransferase and N1-methyl-nicotinamide oxidase activities in the livers of the rats administered alkylating agents. Ohkubo M, et al. Cancer Lett, 1983 Dec. PMID 6652621
    5. Nicotinamide methylation. Tissue distribution, developmental and neoplastic changes. Seifert R, et al. Biochim Biophys Acta, 1984 Sep 28. PMID 6236853

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Progression of pulmonary hypertension is associated with the activation of the NNMT-1-methylnicotinamide pathway.
      Title: Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension.
    2. The downregulation of NNMT by PEITC is a novel finding that may represent an important mechanism for the cancer preventive effects of dietary PEITC.
      Title: Effect of orally administered phenethyl isothiocyanate on hepatic gene expression in rats.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nicotinamide N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nicotinamide N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables selenol Se-methyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nicotinamide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein deacetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    nicotinamide N-methyltransferase
    NP_001100289.1
    XP_038936990.1
    XP_038936991.1
    XP_038936993.1
    XP_038936994.1
    XP_038936995.1
    XP_063121183.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106819.1 → NP_001100289.1  nicotinamide N-methyltransferase

      See identical proteins and their annotated locations for NP_001100289.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473975
      UniProtKB/TrEMBL
      A6J4A4, D4A605
      Conserved Domains (1) summary
      pfam01234
      Location:2 → 259
      NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      57820156..57851301 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081062.2 → XP_038936990.1  nicotinamide N-methyltransferase isoform X2

      Related
      ENSRNOP00000086644.2, ENSRNOT00000117251.2
      Conserved Domains (1) summary
      pfam01234
      Location:2 → 236
      NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

    2. XM_063265113.1 → XP_063121183.1  nicotinamide N-methyltransferase isoform X1

      UniProtKB/TrEMBL
      A6J4A4, D4A605

    3. XM_039081065.2 → XP_038936993.1  nicotinamide N-methyltransferase isoform X4

      Conserved Domains (1) summary
      cl17173
      Location:18 → 164
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    4. XM_039081066.2 → XP_038936994.1  nicotinamide N-methyltransferase isoform X4

      Conserved Domains (1) summary
      cl17173
      Location:18 → 164
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    5. XM_039081067.2 → XP_038936995.1  nicotinamide N-methyltransferase isoform X5

      Conserved Domains (1) summary
      cl17173
      Location:2 → 121
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    6. XM_039081063.2 → XP_038936991.1  nicotinamide N-methyltransferase isoform X3

      Conserved Domains (1) summary
      cl17173
      Location:2 → 136
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous