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    BAZ2B bromodomain adjacent to zinc finger domain 2B [ Homo sapiens (human) ]

    Gene ID: 29994, updated on 2-Nov-2024

    Summary

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    Official Symbol
    BAZ2Bprovided by HGNC
    Official Full Name
    bromodomain adjacent to zinc finger domain 2Bprovided by HGNC
    Primary source
    HGNC:HGNC:963
    See related
    Ensembl:ENSG00000123636 MIM:605683; AllianceGenome:HGNC:963
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    WALp4
    Summary
    This gene belongs to the bromodomain gene family. Members of this gene family encode proteins that are integral components of chromatin remodeling complexes. The encoded protein showed strong preference for the activating H3K14Ac mark in a histone peptide screen, suggesting a potential role in transcriptional activation. This gene may be associated with susceptibility to sudden cardiac death (SCD). [provided by RefSeq, Aug 2016]
    Expression
    Ubiquitous expression in testis (RPKM 7.8), thyroid (RPKM 5.2) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See BAZ2B in Genome Data Viewer
    Location:
    2q24.2
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (159315312..159712442, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (159772618..160169805, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (160175490..160568953, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53596 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16683 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16684 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:160067858-160068472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:160081586-160082095 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:160082096-160082604 Neighboring gene uncharacterized LOC105373716 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53635 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53624 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53665 Neighboring gene microRNA 6888 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:160113609-160113777 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:160128197-160128698 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:160128699-160129198 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53748 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:160143174-160143343 Neighboring gene WD repeat, sterile alpha motif and U-box domain containing 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:160205700-160206899 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:160294250-160295449 Neighboring gene Sharpr-MPRA regulatory region 4770 Neighboring gene CAPZA1 pseudogene 2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53833 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:160455742-160456242 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:160471010-160471538 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:160472595-160473121 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:160480245-160480746 Neighboring gene BAZ2B antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:160568592-160569258 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12044 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:160594100-160595092 Neighboring gene RPS3A pseudogene 13 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53909 Neighboring gene membrane associated ring-CH-type finger 7 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_53950 Neighboring gene LY75-CD302 readthrough Neighboring gene uncharacterized LOC124906083 Neighboring gene CD302 molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Circulating tumor DNA, and clinical features to guide rechallenge with BRAF inhibitors in BRAF-V600E mutated metastatic colorectal cancer. Ros J, et al. Ann Oncol, 2024 Feb. PMID 37866812
    2. Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals. Arking DE, et al. PLoS Genet, 2011 Jun. PMID 21738491, Free PMC Article
    3. Targeting low-druggability bromodomains: fragment based screening and inhibitor design against the BAZ2B bromodomain. Ferguson FM, et al. J Med Chem, 2013 Dec 27. PMID 24304323, Free PMC Article
    4. Binding hotspots of BAZ2B bromodomain: Histone interaction revealed by solution NMR driven docking. Ferguson FM, et al. Biochemistry, 2014 Oct 28. PMID 25266743, Free PMC Article
    5. Structure enabled design of BAZ2-ICR, a chemical probe targeting the bromodomains of BAZ2A and BAZ2B. Drouin L, et al. J Med Chem, 2015 Mar 12. PMID 25719566, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circulating tumor DNA, and clinical features to guide rechallenge with BRAF inhibitors in BRAF-V600E mutated metastatic colorectal cancer.
      Title: Circulating tumor DNA, and clinical features to guide rechallenge with BRAF inhibitors in BRAF-V600E mutated metastatic colorectal cancer.
    2. Biochemical and cellular insights into the Baz2B protein, a non-catalytic subunit of the chromatin remodeling complex.
      Title: Biochemical and cellular insights into the Baz2B protein, a non-catalytic subunit of the chromatin remodeling complex.
    3. The Master Regulator Protein BAZ2B Can Reprogram Human Hematopoietic Lineage-Committed Progenitors into a Multipotent State.
      Title: The Master Regulator Protein BAZ2B Can Reprogram Human Hematopoietic Lineage-Committed Progenitors into a Multipotent State.
    4. BAZ2B haploinsufficiency as a cause of developmental delay, intellectual disability, and autism spectrum disorder.
      Title: BAZ2B haploinsufficiency as a cause of developmental delay, intellectual disability, and autism spectrum disorder.
    5. Study identified BAZ2B as a major interactant of small hepatitis delta virus (HDV) antigen (S-HDAg) in human hepatocytes. BAZ2B bromodomain, which generally binds the K14acXXR motif in histone H3-tail, recognizes the same K72acXXR motif in S-HDAg. S-HDAg mimics histone H3 acetylation to recruit BAZ2B-associated remodeling factor complexes and RNA Pol II on the HDV ribonucleoproteins to sustain HDV replication.
      Title: Hepatitis Delta Virus histone mimicry drives the recruitment of chromatin remodelers for viral RNA replication.
    6. Synergistic inhibition of BDs encoded in BAZ2A/B, BRD9, and BET proteins induces apoptosis of triple-negative breast cancer (TNBC) by a combinatorial suppression of ribosomal DNA transcription and ETS-regulated genes.
      Title: GSK2801, a BAZ2/BRD9 Bromodomain Inhibitor, Synergizes with BET Inhibitors to Induce Apoptosis in Triple-Negative Breast Cancer.
    7. Phosphorylation, acetylation, or poly(ADP-ribosyl)ation of the linker residues may therefore act as a cellular mechanism to transiently tune BAZ2B histone-binding affinity.
      Title: A histone-mimicking interdomain linker in a multidomain protein modulates multivalent histone binding.
    8. Data suggest that binding of helical tail of histone 3 (H3) with PHD ('plant homeodomain') fingers of BAZ2A or BAZ2B (bromodomain adjacent to zinc finger domain 2A or 2B) requires molecular recognition of secondary structure motifs within H3 tail and could represent an additional layer of regulation in epigenetic processes.
      Title: Structural basis of molecular recognition of helical histone H3 tail by PHD finger domains.
    9. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
      Title: Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of bromodomain adjacent to zinc finger domain, 2B (BAZ2B) by siRNA has both activating and inhibiting activities on HIV-1 replication in HeLa P4/R5 cells, suggesting a regulatory role in HIV replication PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ13504, FLJ20669, FLJ45644, AC009961.3, DKFZp434H071, DKFZp686D1284, DKFZp762I0516

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bromodomain adjacent to zinc finger domain protein 2B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051314.1 RefSeqGene

      Range
      100892..398461
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001289975.1 → NP_001276904.1  bromodomain adjacent to zinc finger domain protein 2B isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
      Source sequence(s)
      AC008277, AC009506
      Consensus CDS
      CCDS74594.1
      UniProtKB/Swiss-Prot
      Q9UIF8
      Related
      ENSP00000376533.1, ENST00000392782.5
      Conserved Domains (8) summary
      cd05503
      Location:2029 → 2125
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:1053 → 1115
      DDT; domain in different transcription and chromosome remodeling factors
      cd01397
      Location:742 → 811
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15630
      Location:1896 → 1944
      PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
      pfam15346
      Location:861 → 1014
      ARGLU; Arginine and glutamate-rich 1
      pfam15614
      Location:1682 → 1720
      WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
      cd16269
      Location:959 → 979
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:816 → 1000
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. NM_001329857.2 → NP_001316786.1  bromodomain adjacent to zinc finger domain protein 2B isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains multiple differences in the CDS, compared to variant 1. It encodes isoform c, which is shorter than isoform a.
      Source sequence(s)
      AC008277, AC009506

    3. NM_001329858.2 → NP_001316787.1  bromodomain adjacent to zinc finger domain protein 2B isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon and contains an additional alternate exon in the CDS, compared to variant 1. It encodes isoform d, which is shorter than isoform a.
      Source sequence(s)
      AC008277, AC009506

    4. NM_013450.4 → NP_038478.2  bromodomain adjacent to zinc finger domain protein 2B isoform a

      See identical proteins and their annotated locations for NP_038478.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AC008277, AC009506
      Consensus CDS
      CCDS2209.2
      UniProtKB/Swiss-Prot
      D3DPA8, Q96EA1, Q96SQ8, Q9P252, Q9UIF8, Q9Y4N8
      Related
      ENSP00000376534.2, ENST00000392783.7
      Conserved Domains (8) summary
      cd05503
      Location:2065 → 2161
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:1089 → 1151
      DDT; domain in different transcription and chromosome remodeling factors
      cd01397
      Location:744 → 816
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15630
      Location:1932 → 1980
      PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
      pfam15346
      Location:897 → 1050
      ARGLU; Arginine and glutamate-rich 1
      pfam15614
      Location:1718 → 1756
      WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
      cd16269
      Location:995 → 1015
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:852 → 1036
      GBP_C; Guanylate-binding protein, C-terminal domain

    RNA

    1. NR_110586.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate exon structure, compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.
      Source sequence(s)
      AC009961

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      159315312..159712442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047444047.1 → XP_047300003.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    2. XM_047444046.1 → XP_047300002.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    3. XM_047444040.1 → XP_047299996.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    4. XM_047444044.1 → XP_047300000.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    5. XM_047444043.1 → XP_047299999.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    6. XM_047444055.1 → XP_047300011.1  bromodomain adjacent to zinc finger domain protein 2B isoform X17

    7. XM_047444052.1 → XP_047300008.1  bromodomain adjacent to zinc finger domain protein 2B isoform X12

    8. XM_047444038.1 → XP_047299994.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    9. XM_017003920.2 → XP_016859409.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

      Conserved Domains (7) summary
      cd05503
      Location:2111 → 2207
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:1100 → 1162
      DDT; domain in different transcription and chromosome remodeling factors
      cd01397
      Location:744 → 816
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15630
      Location:1978 → 2026
      PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
      pfam13868
      Location:886 → 1072
      TPH; Trichohyalin-plectin-homology domain
      pfam15613
      Location:1383 → 1415
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      cl25599
      Location:25 → 209
      Nucleoporin_FG2; Nucleoporin FG repeated region

    10. XM_047444048.1 → XP_047300004.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    11. XM_047444039.1 → XP_047299995.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    12. XM_047444045.1 → XP_047300001.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    13. XM_047444041.1 → XP_047299997.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    14. XM_047444042.1 → XP_047299998.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    15. XM_005246488.3 → XP_005246545.2  bromodomain adjacent to zinc finger domain protein 2B isoform X3

      See identical proteins and their annotated locations for XP_005246545.2

      Conserved Domains (7) summary
      cd05503
      Location:2111 → 2207
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:1100 → 1162
      DDT; domain in different transcription and chromosome remodeling factors
      cd01397
      Location:744 → 816
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15630
      Location:1978 → 2026
      PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
      pfam13868
      Location:886 → 1072
      TPH; Trichohyalin-plectin-homology domain
      pfam15613
      Location:1383 → 1415
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      cl25599
      Location:25 → 209
      Nucleoporin_FG2; Nucleoporin FG repeated region

    16. XM_047444051.1 → XP_047300007.1  bromodomain adjacent to zinc finger domain protein 2B isoform X11

    17. XM_047444037.1 → XP_047299993.1  bromodomain adjacent to zinc finger domain protein 2B isoform X2

    18. XM_005246492.5 → XP_005246549.2  bromodomain adjacent to zinc finger domain protein 2B isoform X4

      Conserved Domains (10) summary
      cd05503
      Location:2109 → 2205
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:1098 → 1160
      DDT; domain in different transcription and chromosome remodeling factors
      cd01397
      Location:742 → 814
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15630
      Location:1976 → 2024
      PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
      pfam14738
      Location:864 → 958
      PaaSYMP; Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1
      pfam15346
      Location:904 → 1075
      ARGLU; Arginine and glutamate-rich 1
      pfam15614
      Location:1727 → 1765
      WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
      cd16269
      Location:1039 → 1049
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:978 → 1069
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23765
      Location:913 → 1021
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    19. XM_047444059.1 → XP_047300015.1  bromodomain adjacent to zinc finger domain protein 2B isoform X24

    20. XM_005246489.5 → XP_005246546.2  bromodomain adjacent to zinc finger domain protein 2B isoform X3

      See identical proteins and their annotated locations for XP_005246546.2

      Conserved Domains (7) summary
      cd05503
      Location:2111 → 2207
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:1100 → 1162
      DDT; domain in different transcription and chromosome remodeling factors
      cd01397
      Location:744 → 816
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15630
      Location:1978 → 2026
      PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
      pfam13868
      Location:886 → 1072
      TPH; Trichohyalin-plectin-homology domain
      pfam15613
      Location:1383 → 1415
      WSD; Williams-Beuren syndrome DDT (WSD), D-TOX E motif
      cl25599
      Location:25 → 209
      Nucleoporin_FG2; Nucleoporin FG repeated region

    21. XM_047444064.1 → XP_047300020.1  bromodomain adjacent to zinc finger domain protein 2B isoform X30

    22. XM_047444057.1 → XP_047300013.1  bromodomain adjacent to zinc finger domain protein 2B isoform X19

    23. XM_011511045.1 → XP_011509347.1  bromodomain adjacent to zinc finger domain protein 2B isoform X15

      Conserved Domains (10) summary
      cd05503
      Location:2046 → 2142
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:1035 → 1097
      DDT; domain in different transcription and chromosome remodeling factors
      cd01397
      Location:679 → 751
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15630
      Location:1913 → 1961
      PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
      pfam14738
      Location:801 → 895
      PaaSYMP; Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1
      pfam15346
      Location:841 → 1012
      ARGLU; Arginine and glutamate-rich 1
      pfam15614
      Location:1664 → 1702
      WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
      cd16269
      Location:976 → 986
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:915 → 1006
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23765
      Location:850 → 958
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    24. XM_047444062.1 → XP_047300018.1  bromodomain adjacent to zinc finger domain protein 2B isoform X28

    25. XM_047444056.1 → XP_047300012.1  bromodomain adjacent to zinc finger domain protein 2B isoform X18

    26. XM_011511050.1 → XP_011509352.1  bromodomain adjacent to zinc finger domain protein 2B isoform X21

      Conserved Domains (10) summary
      cd05503
      Location:2011 → 2107
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:1000 → 1062
      DDT; domain in different transcription and chromosome remodeling factors
      cd01397
      Location:644 → 716
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15630
      Location:1878 → 1926
      PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
      pfam14738
      Location:766 → 860
      PaaSYMP; Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1
      pfam15346
      Location:806 → 977
      ARGLU; Arginine and glutamate-rich 1
      pfam15614
      Location:1629 → 1667
      WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
      cd16269
      Location:941 → 951
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:880 → 971
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23765
      Location:815 → 923
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    27. XM_047444050.1 → XP_047300006.1  bromodomain adjacent to zinc finger domain protein 2B isoform X9

    28. XM_017003924.1 → XP_016859413.1  bromodomain adjacent to zinc finger domain protein 2B isoform X8

    29. XM_047444061.1 → XP_047300017.1  bromodomain adjacent to zinc finger domain protein 2B isoform X27

    30. XM_047444060.1 → XP_047300016.1  bromodomain adjacent to zinc finger domain protein 2B isoform X26

    31. XM_011511052.1 → XP_011509354.1  bromodomain adjacent to zinc finger domain protein 2B isoform X25

      Conserved Domains (10) summary
      cd05503
      Location:1979 → 2075
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:968 → 1030
      DDT; domain in different transcription and chromosome remodeling factors
      cd01397
      Location:646 → 715
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15630
      Location:1846 → 1894
      PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
      pfam14738
      Location:734 → 828
      PaaSYMP; Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1
      pfam15346
      Location:774 → 945
      ARGLU; Arginine and glutamate-rich 1
      pfam15614
      Location:1597 → 1635
      WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
      cd16269
      Location:909 → 919
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:848 → 939
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23765
      Location:783 → 891
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    32. XM_047444058.1 → XP_047300014.1  bromodomain adjacent to zinc finger domain protein 2B isoform X23

    33. XM_017003930.2 → XP_016859419.1  bromodomain adjacent to zinc finger domain protein 2B isoform X20

    34. XM_011511043.1 → XP_011509345.1  bromodomain adjacent to zinc finger domain protein 2B isoform X10

      Related
      ENSP00000520831.1, ENST00000718451.1
      Conserved Domains (8) summary
      cd05503
      Location:2066 → 2162
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:1055 → 1117
      DDT; domain in different transcription and chromosome remodeling factors
      cd01397
      Location:744 → 813
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15630
      Location:1933 → 1981
      PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
      pfam15346
      Location:863 → 1016
      ARGLU; Arginine and glutamate-rich 1
      pfam15614
      Location:1684 → 1722
      WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
      cd16269
      Location:961 → 981
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:818 → 1002
      GBP_C; Guanylate-binding protein, C-terminal domain

    35. XM_047444049.1 → XP_047300005.1  bromodomain adjacent to zinc finger domain protein 2B isoform X7

    36. XM_011511038.3 → XP_011509340.1  bromodomain adjacent to zinc finger domain protein 2B isoform X1

      Conserved Domains (9) summary
      cd05503
      Location:2109 → 2205
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:1098 → 1160
      DDT; domain in different transcription and chromosome remodeling factors
      cd01397
      Location:744 → 816
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15630
      Location:1976 → 2024
      PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
      pfam14738
      Location:866 → 960
      PaaSYMP; Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1
      pfam15346
      Location:906 → 1075
      ARGLU; Arginine and glutamate-rich 1
      pfam15614
      Location:1727 → 1765
      WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
      cd16269
      Location:1039 → 1049
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:956 → 1069
      GBP_C; Guanylate-binding protein, C-terminal domain

    37. XM_011511042.1 → XP_011509344.1  bromodomain adjacent to zinc finger domain protein 2B isoform X6

      Conserved Domains (10) summary
      cd05503
      Location:2076 → 2172
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:1100 → 1162
      DDT; domain in different transcription and chromosome remodeling factors
      cd01397
      Location:744 → 816
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15630
      Location:1943 → 1991
      PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
      pfam14738
      Location:866 → 960
      PaaSYMP; Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1
      pfam15346
      Location:906 → 1077
      ARGLU; Arginine and glutamate-rich 1
      pfam15614
      Location:1729 → 1767
      WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
      cd16269
      Location:1041 → 1051
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:980 → 1071
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23765
      Location:915 → 1023
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    38. XM_011511056.2 → XP_011509358.1  bromodomain adjacent to zinc finger domain protein 2B isoform X32

      Conserved Domains (7) summary
      cd05503
      Location:1295 → 1391
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:284 → 346
      DDT; domain in different transcription and chromosome remodeling factors
      cd15630
      Location:1162 → 1210
      PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
      pfam15614
      Location:913 → 951
      WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
      cd16269
      Location:231 → 242
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:164 → 261
      GBP_C; Guanylate-binding protein, C-terminal domain
      cl23765
      Location:99 → 207
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    39. XM_011511051.1 → XP_011509353.1  bromodomain adjacent to zinc finger domain protein 2B isoform X22

      Conserved Domains (9) summary
      cd05503
      Location:2038 → 2134
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:1062 → 1124
      DDT; domain in different transcription and chromosome remodeling factors
      cd01397
      Location:742 → 811
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15630
      Location:1905 → 1953
      PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
      pfam14738
      Location:830 → 924
      PaaSYMP; Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1
      pfam15346
      Location:861 → 1023
      ARGLU; Arginine and glutamate-rich 1
      pfam15614
      Location:1691 → 1729
      WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
      cd16269
      Location:1012 → 1023
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:944 → 1039
      GBP_C; Guanylate-binding protein, C-terminal domain

    40. XM_047444063.1 → XP_047300019.1  bromodomain adjacent to zinc finger domain protein 2B isoform X29

    41. XM_047444054.1 → XP_047300010.1  bromodomain adjacent to zinc finger domain protein 2B isoform X16

    42. XM_011511044.1 → XP_011509346.1  bromodomain adjacent to zinc finger domain protein 2B isoform X13

      Conserved Domains (9) summary
      cd05503
      Location:2075 → 2171
      Bromo_BAZ2A_B_like; Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting ...
      smart00571
      Location:1064 → 1126
      DDT; domain in different transcription and chromosome remodeling factors
      cd01397
      Location:744 → 813
      HAT_MBD; Methyl-CpG binding domains (MBD) present in putative chromatin remodelling factor such as BAZ2A; BAZ2A contains a MBD, DDT, PHD-type zinc finger and Bromo domain suggesting that BAZ2A might be associated with histone acetyltransferase (HAT) activity. The ...
      cd15630
      Location:1942 → 1990
      PHD_BAZ2B; PHD finger found in bromodomain adjacent to zinc finger domain protein 2B (BAZ2B)
      pfam14738
      Location:832 → 926
      PaaSYMP; Solute carrier (proton/amino acid symporter), TRAMD3 or PAT1
      pfam15346
      Location:872 → 1041
      ARGLU; Arginine and glutamate-rich 1
      pfam15614
      Location:1693 → 1731
      WHIM3; WSTF, HB1, Itc1p, MBD9 motif 3
      cd16269
      Location:1014 → 1025
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:946 → 1041
      GBP_C; Guanylate-binding protein, C-terminal domain

    43. XM_047444053.1 → XP_047300009.1  bromodomain adjacent to zinc finger domain protein 2B isoform X14

    44. XM_017003923.1 → XP_016859412.1  bromodomain adjacent to zinc finger domain protein 2B isoform X5

    45. XM_047444065.1 → XP_047300021.1  bromodomain adjacent to zinc finger domain protein 2B isoform X31

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      159772618..160169805 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341579.1 → XP_054197554.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    2. XM_054341573.1 → XP_054197548.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    3. XM_054341576.1 → XP_054197551.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    4. XM_054341594.1 → XP_054197569.1  bromodomain adjacent to zinc finger domain protein 2B isoform X17

    5. XM_054341589.1 → XP_054197564.1  bromodomain adjacent to zinc finger domain protein 2B isoform X12

    6. XM_054341570.1 → XP_054197545.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    7. XM_054341571.1 → XP_054197546.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    8. XM_054341577.1 → XP_054197552.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    9. XM_054341574.1 → XP_054197549.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    10. XM_054341575.1 → XP_054197550.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    11. XM_054341578.1 → XP_054197553.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    12. XM_054341572.1 → XP_054197547.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    13. XM_054341580.1 → XP_054197555.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    14. XM_054341588.1 → XP_054197563.1  bromodomain adjacent to zinc finger domain protein 2B isoform X11

    15. XM_054341569.1 → XP_054197544.1  bromodomain adjacent to zinc finger domain protein 2B isoform X2

    16. XM_054341581.1 → XP_054197556.1  bromodomain adjacent to zinc finger domain protein 2B isoform X4

    17. XM_054341601.1 → XP_054197576.1  bromodomain adjacent to zinc finger domain protein 2B isoform X24

    18. XM_054341606.1 → XP_054197581.1  bromodomain adjacent to zinc finger domain protein 2B isoform X3

    19. XM_054341608.1 → XP_054197583.1  bromodomain adjacent to zinc finger domain protein 2B isoform X30

    20. XM_054341596.1 → XP_054197571.1  bromodomain adjacent to zinc finger domain protein 2B isoform X19

    21. XM_054341592.1 → XP_054197567.1  bromodomain adjacent to zinc finger domain protein 2B isoform X15

    22. XM_054341605.1 → XP_054197580.1  bromodomain adjacent to zinc finger domain protein 2B isoform X28

    23. XM_054341595.1 → XP_054197570.1  bromodomain adjacent to zinc finger domain protein 2B isoform X18

    24. XM_054341598.1 → XP_054197573.1  bromodomain adjacent to zinc finger domain protein 2B isoform X21

    25. XM_054341586.1 → XP_054197561.1  bromodomain adjacent to zinc finger domain protein 2B isoform X9

    26. XM_054341585.1 → XP_054197560.1  bromodomain adjacent to zinc finger domain protein 2B isoform X8

    27. XM_054341604.1 → XP_054197579.1  bromodomain adjacent to zinc finger domain protein 2B isoform X27

    28. XM_054341603.1 → XP_054197578.1  bromodomain adjacent to zinc finger domain protein 2B isoform X26

    29. XM_054341602.1 → XP_054197577.1  bromodomain adjacent to zinc finger domain protein 2B isoform X25

    30. XM_054341600.1 → XP_054197575.1  bromodomain adjacent to zinc finger domain protein 2B isoform X23

    31. XM_054341597.1 → XP_054197572.1  bromodomain adjacent to zinc finger domain protein 2B isoform X20

    32. XM_054341587.1 → XP_054197562.1  bromodomain adjacent to zinc finger domain protein 2B isoform X10

    33. XM_054341584.1 → XP_054197559.1  bromodomain adjacent to zinc finger domain protein 2B isoform X7

    34. XM_054341568.1 → XP_054197543.1  bromodomain adjacent to zinc finger domain protein 2B isoform X1

    35. XM_054341583.1 → XP_054197558.1  bromodomain adjacent to zinc finger domain protein 2B isoform X6

    36. XM_054341610.1 → XP_054197585.1  bromodomain adjacent to zinc finger domain protein 2B isoform X32

    37. XM_054341599.1 → XP_054197574.1  bromodomain adjacent to zinc finger domain protein 2B isoform X22

    38. XM_054341607.1 → XP_054197582.1  bromodomain adjacent to zinc finger domain protein 2B isoform X29

    39. XM_054341593.1 → XP_054197568.1  bromodomain adjacent to zinc finger domain protein 2B isoform X16

    40. XM_054341590.1 → XP_054197565.1  bromodomain adjacent to zinc finger domain protein 2B isoform X13

    41. XM_054341591.1 → XP_054197566.1  bromodomain adjacent to zinc finger domain protein 2B isoform X14

    42. XM_054341582.1 → XP_054197557.1  bromodomain adjacent to zinc finger domain protein 2B isoform X5

    43. XM_054341609.1 → XP_054197584.1  bromodomain adjacent to zinc finger domain protein 2B isoform X31

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UIF8.3 GenPept UniProtKB/Swiss-Prot:Q9UIF8

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