Rxylt1 ribitol xylosyltransferase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rxylt1provided by RGD
Official Full Name: ribitol xylosyltransferase 1provided by RGD
Primary source: RGD:1309356
See related: EnsemblRapid:ENSRNOG00000004421 AllianceGenome:RGD:1309356
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tmem5
Summary: Predicted to enable ribitol beta-1,4-xylosyltransferase activity. Predicted to be involved in protein O-linked mannosylation. Predicted to be located in nucleoplasm. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in congenital muscular dystrophy-dystroglycanopathy type A10. Orthologous to human RXYLT1 (ribitol xylosyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 85.3), Brain (RPKM 84.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (59656274..59668140, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (57770841..57782695, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (64329341..64341201, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ribitol beta-1,4-xylosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribitol beta-1,4-xylosyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein O-linked mannosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein O-linked mannosylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ribitol-5-phosphate xylosyltransferase 1

Names: transmembrane protein 5

NP_001019930.2

EC 2.4.2.61

XP_008763613.1

EC 2.4.2.61

XP_038934677.1

EC 2.4.2.61

XP_038934678.1

EC 2.4.2.61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024759.2 → NP_001019930.2 ribitol-5-phosphate xylosyltransferase 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A6HQM9, F7EM09, Q4V8J9

Related

ENSRNOP00000006051.7, ENSRNOT00000006051.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

59656274..59668140 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008765391.4 → XP_008763613.1 ribitol-5-phosphate xylosyltransferase 1 isoform X1
XM_039078749.2 → XP_038934677.1 ribitol-5-phosphate xylosyltransferase 1 isoform X2
XM_039078750.2 → XP_038934678.1 ribitol-5-phosphate xylosyltransferase 1 isoform X2