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    VPREB3 V-set pre-B cell surrogate light chain 3 [ Homo sapiens (human) ]

    Gene ID: 29802, updated on 2-Nov-2024

    Summary

    Official Symbol
    VPREB3provided by HGNC
    Official Full Name
    V-set pre-B cell surrogate light chain 3provided by HGNC
    Primary source
    HGNC:HGNC:12710
    See related
    Ensembl:ENSG00000128218 IMGT/GENE-DB:VPREB3; MIM:605017; AllianceGenome:HGNC:12710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    8HS20; N27C7-2
    Summary
    The protein encoded by this gene is the human ortholog of the mouse VpreB3 (8HS20) protein, is thought to be involved in B-cell maturation, and may play a role in assembly of the pre-B cell receptor (pre-BCR). While the role of this protein in B-cell development has not yet been elucidated, studies with the chicken ortholog of this protein have found that when overexpressed, this protein localizes to the endoplasmic reticulum. The mouse ortholog of this protein has been shown to associate with membrane mu heavy chains early in the course of pre-B cell receptor biosynthesis. Expression of this gene has been observed in some lymphomas. [provided by RefSeq, Apr 2015]
    Expression
    Biased expression in lymph node (RPKM 35.6), spleen (RPKM 23.3) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See VPREB3 in Genome Data Viewer
    Location:
    22q11.23; 22q11
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (23752743..23754425, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (24199936..24201618, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (24094930..24096612, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905088 Neighboring gene zinc finger protein 70 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:24087516-24088016 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:24088017-24088517 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:24093057-24093732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18759 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24095085-24095758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24096535-24097035 Neighboring gene chromosome 22 open reading frame 15 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:24107697-24108496 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:24108497-24109296 Neighboring gene uncharacterized LOC107985577 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 10

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    part_of immunoglobulin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    pre-B lymphocyte protein 3
    Names
    pre-B lymphocyte 3
    pre-B lymphocyte gene 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013378.3NP_037510.1  pre-B lymphocyte protein 3 precursor

      See identical proteins and their annotated locations for NP_037510.1

      Status: REVIEWED

      Source sequence(s)
      AF163825, AY359000, BQ899182
      Consensus CDS
      CCDS13813.1
      UniProtKB/Swiss-Prot
      B2R587, Q9UKI3
      UniProtKB/TrEMBL
      A8MX21
      Related
      ENSP00000248948.3, ENST00000248948.4
      Conserved Domains (1) summary
      cl11960
      Location:30122
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      23752743..23754425 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      24199936..24201618 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)