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    Smim8 small integral membrane protein 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297971, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Smim8provided by RGD
    Official Full Name
    small integral membrane protein 8provided by RGD
    Primary source
    RGD:1305158
    See related
    EnsemblRapid:ENSRNOG00000023035 AllianceGenome:RGD:1305158
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1305158
    Summary
    Predicted to be located in mitochondrion. Orthologous to human SMIM8 (small integral membrane protein 8). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Heart (RPKM 75.3), Muscle (RPKM 68.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Smim8 in Genome Data Viewer
    Location:
    5q21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (54132905..54141940, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (49336617..49345625, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (50230617..50239651, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 206 Neighboring gene similar to human chromosome 6 open reading frame 163 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA U3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Morgenstern M, et al. Cell Metab, 2021 Dec 7. PMID 34800366, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    small integral membrane protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201374.2 → NP_001188303.1  small integral membrane protein 8

      See identical proteins and their annotated locations for NP_001188303.1

      Status: VALIDATED

      Source sequence(s)
      DY544415, JAXUCZ010000005
      UniProtKB/TrEMBL
      A6IIN4, G3V8Z7
      Conserved Domains (1) summary
      pfam14937
      Location:16 → 96
      DUF4500; Domain of unknown function (DUF4500)

    2. NM_001201375.2 → NP_001188304.1  small integral membrane protein 8

      See identical proteins and their annotated locations for NP_001188304.1

      Status: VALIDATED

      Source sequence(s)
      FM105726, JAXUCZ010000005
      UniProtKB/TrEMBL
      A6IIN4, G3V8Z7
      Related
      ENSRNOP00000071723.1, ENSRNOT00000089172.3
      Conserved Domains (1) summary
      pfam14937
      Location:16 → 96
      DUF4500; Domain of unknown function (DUF4500)

    3. NM_001359878.1 → NP_001346807.1  small integral membrane protein 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6IIN4, G3V8Z7
      Conserved Domains (1) summary
      pfam14937
      Location:16 → 96
      DUF4500; Domain of unknown function (DUF4500)

    RNA

    1. NR_153367.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BC167112, JAXUCZ010000005
      Related
      ENSRNOT00000137628.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      54132905..54141940 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287301.1 → XP_063143371.1  small integral membrane protein 8 isoform X2

    2. XM_006237987.5 → XP_006238049.1  small integral membrane protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006238049.1

      UniProtKB/TrEMBL
      A6IIN4, G3V8Z7
      Conserved Domains (1) summary
      pfam14937
      Location:16 → 96
      DUF4500; Domain of unknown function (DUF4500)

    3. XM_039109437.2 → XP_038965365.1  small integral membrane protein 8 isoform X1

      UniProtKB/TrEMBL
      A6IIN4, G3V8Z7
      Conserved Domains (1) summary
      pfam14937
      Location:16 → 96
      DUF4500; Domain of unknown function (DUF4500)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106644.1: Suppressed sequence

      Description
      NM_001106644.1: This RefSeq was removed because currently there is insufficient support for the transcript.

    2. NM_001201376.1: Suppressed sequence

      Description
      NM_001201376.1: This RefSeq was removed because currently there is insufficient support for the transcript and protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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