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    Cpa2 carboxypeptidase A2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296959, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cpa2provided by RGD
    Official Full Name
    carboxypeptidase A2provided by RGD
    Primary source
    RGD:1305563
    See related
    EnsemblRapid:ENSRNOG00000010463 AllianceGenome:RGD:1305563
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CPA2(S)
    Summary
    Predicted to enable metallocarboxypeptidase activity and zinc ion binding activity. Predicted to be involved in proteolysis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Orthologous to human CPA2 (carboxypeptidase A2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 4786.0) and Liver (RPKM 1290.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cpa2 in Genome Data Viewer
    Location:
    4q22
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (60125297..60151066)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (59160357..59183677)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (57855416..57879239)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 209 Neighboring gene serine-rich single-pass membrane protein 1 Neighboring gene uncharacterized LOC120102251 Neighboring gene carboxypeptidase A4 Neighboring gene uncharacterized LOC102553416 Neighboring gene carboxypeptidase A5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Carboxypeptidase A isoforms produced by distinct genes or alternative splicing in brain and other extrapancreatic tissues. Normant E, et al. J Biol Chem, 1995 Sep 1. PMID 7657630
    2. A novel rat carboxypeptidase, CPA2: characterization, molecular cloning, and evolutionary implications on substrate specificity in the carboxypeptidase gene family. Gardell SJ, et al. J Biol Chem, 1988 Nov 25. PMID 3182871
    3. Structural evolution of an enzyme specificity. The structure of rat carboxypeptidase A2 at 1.9-A resolution. Faming Z, et al. J Biol Chem, 1991 Dec 25. PMID 1761558
    4. Carboxypeptidases A1 and A2 from the perfusate of rat mesenteric arterial bed differentially process angiotensin peptides. Pereira HJ, et al. Peptides, 2012 Jan. PMID 22178042
    5. Procarboxypeptidase in rat pancreas. Overall characterization and comparison of the activation processes. Oppezzo O, et al. Eur J Biochem, 1994 May 15. PMID 8200353

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallocarboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metallocarboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallocarboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallocarboxypeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carboxypeptidase A2
    Names
    carboxypeptidase A2 (pancreatic)
    NP_001013101.2
    XP_038963208.1
    XP_063141810.1
    XP_063141811.1
    XP_063141812.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013083.2 → NP_001013101.2  carboxypeptidase A2 precursor

      See identical proteins and their annotated locations for NP_001013101.2

      Status: VALIDATED

      Source sequence(s)
      CF249031, CF249075, CF249156, CF249511
      UniProtKB/Swiss-Prot
      P19222, Q6LD54
      UniProtKB/TrEMBL
      A6IEG7, G3V976
      Related
      ENSRNOP00000038495.3, ENSRNOT00000029608.4
      Conserved Domains (2) summary
      cd03870
      Location:116 → 415
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
      pfam02244
      Location:33 → 100
      Propep_M14; Carboxypeptidase activation peptide

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      60125297..60151066
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285740.1 → XP_063141810.1  carboxypeptidase A2 isoform X1

      UniProtKB/TrEMBL
      A6IEG7, G3V976

    2. XM_063285741.1 → XP_063141811.1  carboxypeptidase A2 isoform X1

      UniProtKB/TrEMBL
      A6IEG7, G3V976

    3. XM_063285742.1 → XP_063141812.1  carboxypeptidase A2 isoform X2

    4. XM_039107280.2 → XP_038963208.1  carboxypeptidase A2 isoform X3

      UniProtKB/TrEMBL
      A6IEG8
      Conserved Domains (1) summary
      cd03870
      Location:1 → 285
      M14_CPA; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase A subgroup
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19222.1 GenPept UniProtKB/Swiss-Prot:P19222

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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