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    Chst15 carbohydrate sulfotransferase 15 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286974, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Chst15provided by RGD
    Official Full Name
    carbohydrate sulfotransferase 15provided by RGD
    Primary source
    RGD:628881
    See related
    EnsemblRapid:ENSRNOG00000016267 AllianceGenome:RGD:628881
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    GalNAc4S6ST; Galnac4s-6st
    Summary
    Predicted to enable 3'-phosphoadenosine 5'-phosphosulfate binding activity and N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity. Predicted to be involved in hexose biosynthetic process. Predicted to be located in Golgi membrane. Orthologous to human CHST15 (carbohydrate sulfotransferase 15). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 97.4), Lung (RPKM 60.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Chst15 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (196458978..196540088, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (187028860..187107908, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (204243396..204328960, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene carboxypeptidase X (M14 family), member 2 Neighboring gene ribosomal protein S27, pseudogene 7 Neighboring gene uncharacterized LOC102551752 Neighboring gene uncharacterized LOC134485184 Neighboring gene transfer RNA alanine (anticodon AGC) 75

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Targeted downregulation of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase significantly mitigates chondroitin sulfate proteoglycan-mediated inhibition. Karumbaiah L, et al. Glia, 2011 Jun. PMID 21456043, Free PMC Article
    2. Human N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase cDNA is related to human B cell recombination activating gene-associated gene. Ohtake S, et al. J Biol Chem, 2001 Nov 23. PMID 11572857
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93074

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-phosphoadenosine 5'-phosphosulfate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3'-phosphoadenosine 5'-phosphosulfate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3'-phosphoadenosine 5'-phosphosulfate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in hexose biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in hexose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hexose biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hexose biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    carbohydrate sulfotransferase 15
    Names
    B cell RAG associated protein
    N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
    carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
    NP_775432.3
    XP_006230492.1
    XP_006230493.1
    XP_006230495.1
    XP_017444335.1
    XP_038958651.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173310.3 → NP_775432.3  carbohydrate sulfotransferase 15

      See identical proteins and their annotated locations for NP_775432.3

      Status: PROVISIONAL

      Source sequence(s)
      AB086953
      UniProtKB/Swiss-Prot
      Q5U363, Q8CHI9
      UniProtKB/TrEMBL
      A0A8I6G6L4
      Related
      ENSRNOP00000022157.5, ENSRNOT00000022157.9
      Conserved Domains (1) summary
      cl21551
      Location:253 → 505
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      196458978..196540088 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230430.5 → XP_006230492.1  carbohydrate sulfotransferase 15 isoform X1

      See identical proteins and their annotated locations for XP_006230492.1

      UniProtKB/TrEMBL
      A0A8I6G6L4, A6HWY1, G3V838
      Conserved Domains (1) summary
      cl21551
      Location:253 → 505
      Sulfotransfer_3; Sulfotransferase family

    2. XM_006230433.5 → XP_006230495.1  carbohydrate sulfotransferase 15 isoform X1

      See identical proteins and their annotated locations for XP_006230495.1

      UniProtKB/TrEMBL
      A0A8I6G6L4, A6HWY1, G3V838
      Conserved Domains (1) summary
      cl21551
      Location:253 → 505
      Sulfotransfer_3; Sulfotransferase family

    3. XM_006230431.5 → XP_006230493.1  carbohydrate sulfotransferase 15 isoform X1

      See identical proteins and their annotated locations for XP_006230493.1

      UniProtKB/TrEMBL
      A0A8I6G6L4, A6HWY1, G3V838
      Conserved Domains (1) summary
      cl21551
      Location:253 → 505
      Sulfotransfer_3; Sulfotransferase family

    4. XM_039102723.2 → XP_038958651.1  carbohydrate sulfotransferase 15 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G6L4, A6HWY1, G3V838
      Conserved Domains (1) summary
      cl21551
      Location:253 → 505
      Sulfotransfer_3; Sulfotransferase family

    5. XM_017588846.3 → XP_017444335.1  carbohydrate sulfotransferase 15 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G6L4, A6HWY1, G3V838
      Conserved Domains (1) summary
      cl21551
      Location:253 → 505
      Sulfotransfer_3; Sulfotransferase family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CHI9.1 GenPept UniProtKB/Swiss-Prot:Q8CHI9

    Gene LinkOut

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