DGAT1 diacylglycerol O-acyltransferase 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: DGAT1provided by VGNC
Official Full Name: diacylglycerol O-acyltransferase 1provided by VGNC
Primary source: VGNC:VGNC:28020
See related: Ensembl:ENSBTAG00000026356
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: ARAT; DGAT
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	14	NC_037341.1 (604179..614155)

Chromosome 14 - NC_037341.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_037341.1 Chromosome 14 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of diacylglycerol O-acyltransferase 1 (DGAT1) in lipolysis and autophagy of adipose tissue from ketotic dairy cows.
Title: Role of diacylglycerol O-acyltransferase 1 (DGAT1) in lipolysis and autophagy of adipose tissue from ketotic dairy cows.
Interaction of DGAT1 polymorphism, parity, and acetate supplementation on feeding behavior, milk synthesis, and plasma metabolites.
Title: Interaction of DGAT1 polymorphism, parity, and acetate supplementation on feeding behavior, milk synthesis, and plasma metabolites.
Analysis of the impact of DGAT1 p.M435L and p.K232A variants on pre-mRNA splicing in a full-length gene assay.
Title: Analysis of the impact of DGAT1 p.M435L and p.K232A variants on pre-mRNA splicing in a full-length gene assay.
Association of Single Nucleotide Polymorphism in the DGAT1 Gene with the Fatty Acid Composition of Cows Milked Once and Twice a Day.
Title: Association of Single Nucleotide Polymorphism in the DGAT1 Gene with the Fatty Acid Composition of Cows Milked Once and Twice a Day.
DGAT1 K232A polymorphism is associated with milk production traits in Chinese cattle.
Title: DGAT1 K232A polymorphism is associated with milk production traits in Chinese cattle.
The functions and mechanisms of sequence differences of DGAT1 gene on milk fat synthesis between dairy cow and buffalo.
Title: The functions and mechanisms of sequence differences of DGAT1 gene on milk fat synthesis between dairy cow and buffalo.
These findings demonstrated that milk fat percentage, somatic cell count (SCC), somatic cell score (SCS), serum cytokines interleukin 6 (IL-6) and interferon gamma (IFN-gamma) showed significant associations (P < 0.05) with at least one or more identified single nucleotide polymorphisms (SNPs).
Title: Significant genetic effects of JAK2 and DGAT1 mutations on milk fat content and mastitis resistance in Holsteins.
report on the interaction effect of diacylglycerol O-acyltransferase 1 K232A polymorphism in cows and season on the triacylglycerol composition in milk fat
Title: The DGAT1 K232A polymorphism and feeding modify milk fat triacylglycerol composition.
the effects of dietary linseed oil, DGAT1, and the interaction between dietary linseed oil and DGAT1 on CH4 and H2 emission, energy and N metabolism, lactation performance, ruminal fermentation, and rumen bacterial and archaeal composition of dairy cows
Title: Linseed oil and DGAT1 K232A polymorphism: Effects on methane emission, energy and nitrogen metabolism, lactation performance, ruminal fermentation, and rumen microbial composition of Holstein-Friesian cows.
Here, the association between DGAT1 K232A, SCD1 A293V, and LEPR T945M markers with milk fat composition in southern Chile was evaluated. The most frequent variants for DGAT1, SCD1, and LEPR polymorphisms were GC/GC, C, and C, respectively. The DGAT1 GC/GC allele was associated with lower milk fat and protein content, lower saturated fatty acid levels, and higher polyunsaturated FA
Title: Milk fatty acid profile is modulated by DGAT1 and SCD1 genotypes in dairy cattle on pasture and strategic supplementation.

Submit: New GeneRIF Correction See all GeneRIFs (45)

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables diacylglycerol O-acyltransferase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in triglyceride biosynthetic process	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: diacylglycerol O-acyltransferase 1

Names: acyl-CoA retinol O-fatty-acyltransferase; diacylglycerol O-acyltransferase homolog 1; diacylglycerol acyltransferase; diglyceride acyltransferase; diglyceride acyltransferase 1; putative diacylglycerol acyltransferase 1; retinol O-fatty-acyltransferase

NP_777118.2

EC 2.3.1.20

EC 2.3.1.76

XP_059749112.1

EC 2.3.1.20

EC 2.3.1.76

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.