TLR9 toll like receptor 9 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: TLR9provided by VGNC
Official Full Name: toll like receptor 9provided by VGNC
Primary source: VGNC:VGNC:110071
See related: BGD:BT24694; Ensembl:ENSBTAG00000018198
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	22	NC_037349.1 (48676670..48680933)

Chromosome 22 - NC_037349.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TLR activation, immune response and viral protection elicited in cattle by a commercial vaccine against Bovine Herpesvirus-1.
Title: TLR activation, immune response and viral protection elicited in cattle by a commercial vaccine against Bovine Herpesvirus-1.
variants in the TLR1 gene are associated with susceptibility to bovine tuberculosis, whereas no significant association can be inferred from the polymorphisms in the TLR9 gene
Title: Polymorphisms in toll-like receptor 1 and 9 genes and their association with tuberculosis susceptibility in Chinese Holstein cattle.
we studied TLR9 expression in lung extracts from pigs, dogs, and cattle.
Title: Expression of toll-like receptor 9 in lungs of pigs, dogs and cattle.
mRNA abundances of TLR9, TLR2, and TLR4 together with those of beta-defensin 5 (BNBD5), an early bactericidal effector molecule of the innate system, in healthy and infected mammary glands
Title: Mastitis increases mammary mRNA abundance of beta-defensin 5, toll-like-receptor 2 (TLR2), and TLR4 but not TLR9 in cattle.
substantial conservation of TLR9 structure and TLR9 function in blood leukocytes
Title: Bovine toll-like receptor 9: a comparative analysis of molecular structure, function and expression.
Comparative sequence analysis revealed a total of 139 polymorphisms, which include single-nucleotide polymorphisms and insertion-deletion polymorphisms.
Title: Detection of polymorphisms in bovine toll-like receptors 3, 7, 8, and 9.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables pattern recognition receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info	PubMed
involved_in toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: toll-like receptor 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_183081.1 → NP_898904.1 toll-like receptor 9 precursor

See identical proteins and their annotated locations for NP_898904.1

Status: PROVISIONAL

Source sequence(s)

AJ509824

UniProtKB/TrEMBL

A5H631, Q866B2

Related

ENSBTAP00000024223.2, ENSBTAT00000024223.4

Conserved Domains (5) summary

cd00116
Location:389 → 696

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:750 → 762

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:474 → 495

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:474 → 531

LRR_8; Leucine rich repeat

cl23749
Location:866 → 1009

TIR_2; TIR domain