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    IGF2R insulin like growth factor 2 receptor [ Bos taurus (domestic cattle) ]

    Gene ID: 281849, updated on 4-Oct-2024

    Summary

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    Official Symbol
    IGF2Rprovided by VGNC
    Official Full Name
    insulin like growth factor 2 receptorprovided by VGNC
    Primary source
    VGNC:VGNC:30082
    See related
    BGD:BT10008; Ensembl:ENSBTAG00000002402
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    CIMPR; CI-MPR
    Orthologs
    human mouse all
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    Genomic context

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    See IGF2R in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 9 NC_037336.1 (96197493..96300019)

    Chromosome 9 - NC_037336.1Genomic Context describing neighboring genes Neighboring gene PARN like ribonuclease domain containing exonuclease 1 Neighboring gene MAS1 proto-oncogene, G protein-coupled receptor Neighboring gene antisense IGF2R RNA noncoding Neighboring gene solute carrier family 22 member 1 Neighboring gene solute carrier family 22 member 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037336.1 Chromosome 9 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and sequence analysis of the cation-independent mannose 6-phosphate receptor. Lobel P, et al. J Biol Chem, 1988 Feb 15. PMID 2963004
    2. Igf-2r expression regulated by epigenetic modification and the locus of gene imprinting disrupted in cloned cattle. Long JE, et al. Gene, 2007 Feb 15. PMID 17150312
    3. Identification of a low affinity mannose 6-phosphate-binding site in domain 5 of the cation-independent mannose 6-phosphate receptor. Reddy ST, et al. J Biol Chem, 2004 Sep 10. PMID 15252023
    4. Allelic switching of the imprinted IGF2R gene in cloned bovine fetuses and calves. Suteevun-Phermthai T, et al. Anim Reprod Sci, 2009 Nov. PMID 19217227
    5. The N-terminal carbohydrate recognition site of the cation-independent mannose 6-phosphate receptor. Olson LJ, et al. J Biol Chem, 2004 Aug 6. PMID 15169779

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Genomic imprinting of the IGF2R/AIR locus is conserved between bovines and mice.
      Title: Genomic imprinting of the IGF2R/AIR locus is conserved between bovines and mice.
    2. Components of the insulin-like growth factor system in in vivo - and in vitro-derived fetuses of cattle, and the association with growth and development.
      Title: Components of the insulin-like growth factor system in in vivo - and in vitro-derived fetuses of cattle, and the association with growth and development.
    3. Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments.
      Title: Marked structural rearrangement of mannose 6-phosphate/IGF2 receptor at different pH environments.
    4. Here we examined the transcriptome of skeletal muscle, liver, kidney, and brain of control and LOS bovine fetuses and found that different tissues within LOS fetuses have perturbations of distinct gene pathways... only a small percent of differentially expressed genes (DEGs), including the imprinted gene IGF2R, could be associated with the neighboring differentially methylated regions
      Title: Global misregulation of genes largely uncoupled to DNA methylome epimutations characterizes a congenital overgrowth syndrome.
    5. suggest that the insulin like growth factor 2 receptor(IGF2R) gene polymorphisms could be useful genetic markers for dairy production traits in cattle
      Title: Association of SNP and STR polymorphisms of insulin-like growth factor 2 receptor (IGF2R) gene with milk traits in Holstein-Friesian cows.
    6. study hypothesizes that reduced granulosa cell insulin-like growth factor II receptor expression in F2 follicles of Twinner cows may play a role in the development of 2 or more dominant follicles
      Title: Possible role of IGF2 receptors in regulating selection of 2 dominant follicles in cattle selected for twin ovulations and births.
    7. imprinting of Bos taurus IGF2R is similar to mouse except in placenta, which could indicate an effect of reproductive strategy
      Title: Tissue-specific and minor inter-individual variation in imprinting of IGF2R is a common feature of Bos taurus Concepti and not correlated with fetal weight.
    8. Increases in CYP19A1 and FSHR mRNA expression and decreases in IGF2R mRNA expression in follicles of Twinners support the hypothesis that increased follicular development and steroidogenesis result from increased extra-ovarian IGF-1 production.
      Title: Increased abundance of aromatase and follicle stimulating hormone receptor mRNA and decreased insulin-like growth factor-2 receptor mRNA in small ovarian follicles of cattle selected for twin births.
    9. Sex-sorting procedure by flow cytometry did not affect the overall DNA methylation patterns of the IGF2 and IGF2R genes, although individual variation in their methylation patterns among bulls was observed.
      Title: The methylation patterns of the IGF2 and IGF2R genes in bovine spermatozoa are not affected by flow-cytometric sex sorting.
    10. Study demonstrates associations between IGF2R polymorphisms and growth- and body-related traits in cattle.
      Title: Single nucleotide polymorphisms in the imprinted bovine insulin-like growth factor 2 receptor gene (IGF2R) are associated with body size traits in Irish Holstein-Friesian cattle.
    Submit: New GeneRIF Correction See all GeneRIFs (21)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables D-mannose binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables insulin-like growth factor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in lysosomal transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in late endosome IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cation-independent mannose-6-phosphate receptor
    Names
    300 kDa mannose 6-phosphate receptor
    CI Man-6-P receptor
    IGF-II receptor
    M6PR
    MPR 300
    insulin-like growth factor II receptor
    insulin-like growth factor receptor type 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174352.2 → NP_776777.1  cation-independent mannose-6-phosphate receptor precursor

      See identical proteins and their annotated locations for NP_776777.1

      Status: PROVISIONAL

      Source sequence(s)
      AF342811
      UniProtKB/Swiss-Prot
      P08169
      UniProtKB/TrEMBL
      F1MIE6
      Related
      ENSBTAP00000037502.4, ENSBTAT00000037678.4
      Conserved Domains (3) summary
      smart00059
      Location:1906 → 1951
      FN2; Fibronectin type 2 domain
      pfam00878
      Location:1331 → 1471
      CIMR; Cation-independent mannose-6-phosphate receptor repeat
      cl39051
      Location:649 → 772
      ATG27; Autophagy-related protein 27

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037336.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      96197493..96300019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08169.2 GenPept UniProtKB/Swiss-Prot:P08169

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials