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    BGN biglycan [ Bos taurus (domestic cattle) ]

    Gene ID: 280733, updated on 4-Oct-2024

    Summary

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    Official Symbol
    BGNprovided by VGNC
    Official Full Name
    biglycanprovided by VGNC
    Primary source
    VGNC:VGNC:26481
    See related
    Ensembl:ENSBTAG00000005250
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See BGN in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) X NC_037357.1 (36728478..36742281)

    Chromosome X - NC_037357.1Genomic Context describing neighboring genes Neighboring gene three prime repair exonuclease 2 Neighboring gene HAUS augmin like complex subunit 7 Neighboring gene extracellular matrix protein X-linked Neighboring gene ATPase plasma membrane Ca2+ transporting 3 Neighboring gene cyclin Q

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037357.1 Chromosome X Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of the biglycan dimer and evidence that dimerization is essential for folding and stability of class I small leucine-rich repeat proteoglycans. Scott PG, et al. J Biol Chem, 2006 May 12. PMID 16547006
    2. Primary structure of bovine aorta biglycan core protein deduced from cloned CDNA. Xu JH, et al. Biochem Mol Biol Int, 1995 Oct. PMID 8673009
    3. cDNA sequence for bovine biglycan (PGI) protein core. Torok MA, et al. Biochim Biophys Acta, 1993 Apr 29. PMID 8485158
    4. The primary structure of the core protein of the small, leucine-rich proteoglycan (PG I) from bovine articular cartilage. Neame PJ, et al. J Biol Chem, 1989 May 25. PMID 2656687
    5. Biglycan and decorin induce morphological and cytoskeletal changes involving signalling by the small GTPases RhoA and Rac1 resulting in lung fibroblast migration. Tufvesson E, et al. J Cell Sci, 2003 Dec 1. PMID 14600270

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that biglycan, collagen type I, collagen type II, decorin, and versican were significantly affected by vibration duration, frequency, and amplitude.
      Title: Free axial vibrations at 0 to 200 Hz positively affect extracellular matrix messenger ribonucleic acid expression in bovine nucleus pulposi.
    2. biglycan-induced fibroblast cytoskeletal and signalling changes result in an increased cell migration; potential role in the remodelling process
      Title: Biglycan and decorin induce morphological and cytoskeletal changes involving signalling by the small GTPases RhoA and Rac1 resulting in lung fibroblast migration.
    3. biglycan showed a unique ability to organize collagen VI into extensive hexagonal-like networks over a time period of only a few minutes
      Title: Biglycan organizes collagen VI into hexagonal-like networks resembling tissue structures.
    4. The results indicate that CTGF suppresses the synthesis of biglycan but newly induced that of decorin in the cells when the cell density is low.
      Title: Differential regulation of biglycan and decorin synthesis by connective tissue growth factor in cultured vascular endothelial cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    biglycan
    Names
    PG-S1
    bone/cartilage proteoglycan I
    leucine-rich PG I

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178318.4 → NP_847888.2  biglycan precursor

      See identical proteins and their annotated locations for NP_847888.2

      Status: PROVISIONAL

      Source sequence(s)
      BC118460
      UniProtKB/Swiss-Prot
      P21809, P79259, Q17QB0, Q5BIM3
      UniProtKB/TrEMBL
      A0AAF6ZGY7
      Related
      ENSBTAP00000044462.4, ENSBTAT00000047242.5
      Conserved Domains (3) summary
      PRK15370
      Location:65 → 298
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      sd00031
      Location:303 → 316
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:72 → 92
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037357.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      36728478..36742281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005227658.5 → XP_005227715.1  biglycan isoform X1

      See identical proteins and their annotated locations for XP_005227715.1

      UniProtKB/Swiss-Prot
      P21809, P79259, Q17QB0, Q5BIM3
      UniProtKB/TrEMBL
      A0AAF6ZGY7
      Conserved Domains (3) summary
      PRK15370
      Location:65 → 298
      PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
      sd00031
      Location:303 → 316
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:72 → 92
      LRR_RI; leucine-rich repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21809.3 GenPept UniProtKB/Swiss-Prot:P21809

    Gene LinkOut

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