DISC2 disrupted in schizophrenia 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: DISC2provided by HGNC
Official Full Name: disrupted in schizophrenia 2provided by HGNC
Primary source: HGNC:HGNC:2889
See related: MIM:606271; AllianceGenome:HGNC:2889
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DISC1OS; DISC1-AS1; NCRNA00015
Summary: DISC2 is thought to specify a noncoding RNA molecule antisense to DISC1 (MIM 605210). Both genes were found to be disrupted by a translocation in a large schizophrenia (MIM 181500) kindred.[supplied by OMIM, Jul 2002]
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Genomic context

Location:: 1q42.2

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (231814626..231818517, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (231200158..231204047, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (231950372..231954263, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

that the transcript levels of DISC1 and DISC2 long non-coding RNAs could be considered as a good putative biomarker for individuals with bipolar disorder
Title: Significant increasing of DISC2 long non-coding RNA expression as a potential biomarker in bipolar disorder.
Observational study of gene-disease association. (HuGE Navigator)
Title: Identification of high risk DISC1 structural variants with a 2% attributable risk for schizophrenia.
The potential involvement of DISC2 in the pathogenesis of psychiatric illness is discussed [review].
Title: The DISC locus in psychiatric illness.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Schizophrenia MedGen: C0036341 OMIM: 181500 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Genome-wide association of lipid-lowering response to statins in combined study populations. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

D1S1624 (e-PCR)
- UniSTS:48471

D1S1621 (e-PCR)
- UniSTS:62819

D1S3462 (e-PCR), detects polymorphism
- UniSTS:81919

Other Names

DISC1 antisense RNA 1
DISC1 opposite strand
disrupted in schizophrenia 2 (non-protein coding)

Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.