Rpl7a ribosomal protein L7A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rpl7aprovided by MGI
Official Full Name: ribosomal protein L7Aprovided by MGI
Primary source: MGI:MGI:1353472
See related: Ensembl:ENSMUSG00000062647 AllianceGenome:MGI:1353472
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Surf3
Summary: A structural constituent of ribosome. Predicted to be involved in maturation of LSU-rRNA. Located in cytoplasm; membrane; and ribosome. Part of cytosolic large ribosomal subunit. Is active in synapse. Is expressed in embryo; metanephros; neocortex; spleen; and thymus. Orthologous to human RPL7A (ribosomal protein L7a). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 336.0), CNS E11.5 (RPKM 322.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 19.1 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (26800697..26803330)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (26910685..26913312)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings reveal that the nuclear import of FKBP25 and binding with 60S ribosomal protein L7a are protective stress responses to ischemia/nitrosaive stress injury.
Title: Elucidation of the FKBP25-60S Ribosomal Protein L7a Stress Response Signaling During Ischemic Injury.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:493132

Rpl7a (e-PCR), detects polymorphism
- UniSTS:256401

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of ribosome	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cytoplasmic translation	NAS Non-traceable Author Statement more info	PubMed
involved_in maturation of LSU-rRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info
involved_in translation at postsynapse	NAS Non-traceable Author Statement more info	PubMed
involved_in translation at presynapse	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
part_of cytosolic large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic large ribosomal subunit	IPI Inferred from Physical Interaction more info	PubMed
part_of cytosolic large ribosomal subunit	ISO Inferred from Sequence Orthology more info
located_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	NAS Non-traceable Author Statement more info	PubMed
is_active_in presynapse	NAS Non-traceable Author Statement more info	PubMed
located_in ribosome	IDA Inferred from Direct Assay more info	PubMed
located_in ribosome	ISO Inferred from Sequence Orthology more info
is_active_in ribosome	NAS Non-traceable Author Statement more info	PubMed
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: large ribosomal subunit protein eL8

Names: 60S ribosomal protein L7a; surfeit 3; surfeit locus protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013721.4 → NP_038749.1 large ribosomal subunit protein eL8

See identical proteins and their annotated locations for NP_038749.1

Status: VALIDATED

Source sequence(s)

AL773563

Consensus CDS

CCDS15815.1

UniProtKB/Swiss-Prot

P12970, Q91YM3

UniProtKB/TrEMBL

Q58ET1, Q5EBG5, Q6P1A9

Related

ENSMUSP00000099962.5, ENSMUST00000102898.5

Conserved Domains (1) summary

PTZ00365
Location:16 → 266

PTZ00365; 60S ribosomal protein L7Ae-like; Provisional

RNA

NR_184739.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL773563

Related

ENSMUST00000143678.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

26800697..26803330

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017318923.2 → XP_017174412.1 large ribosomal subunit protein eL8 isoform X1

Related

ENSMUST00000137376.8

Conserved Domains (1) summary

PTZ00365
Location:16 → 207

PTZ00365; 60S ribosomal protein L7Ae-like; Provisional