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    Gtf3c4 general transcription factor IIIC, polypeptide 4 [ Mus musculus (house mouse) ]

    Gene ID: 269252, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Gtf3c4provided by MGI
    Official Full Name
    general transcription factor IIIC, polypeptide 4provided by MGI
    Primary source
    MGI:MGI:2138937
    See related
    Ensembl:ENSMUSG00000035666 AllianceGenome:MGI:2138937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KAT12; TFIIIC90; 5330400C03
    Summary
    Predicted to enable DNA binding activity; RNA polymerase III general transcription initiation factor activity; and histone acetyltransferase activity. Predicted to be involved in chromatin remodeling and transcription initiation at RNA polymerase III promoter. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of transcription factor TFIIIC complex. Is expressed in limb. Orthologous to human GTF3C4 (general transcription factor IIIC subunit 4). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 8.3), whole brain E14.5 (RPKM 7.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gtf3c4 in Genome Data Viewer
    Location:
    2 A3; 2 19.38 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (28712311..28730628, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (28822299..28840360, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene adenylate kinase 8 Neighboring gene microRNA 3088 Neighboring gene STARR-seq mESC enhancer starr_04033 Neighboring gene high mobility group box 3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10088 Neighboring gene DEAD/H box helicase 31 Neighboring gene BarH like homeobox 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. New nomenclature for chromatin-modifying enzymes. Allis CD, et al. Cell, 2007 Nov 16. PMID 18022353
    2. Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks. Latos PA, et al. Genes Dev, 2015 Dec 1. PMID 26584622, Free PMC Article
    3. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article
    4. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase III general transcription initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transcription initiation at RNA polymerase III promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIIC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIIC complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIIC complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    general transcription factor 3C polypeptide 4
    Names
    TF3C-delta
    TFIIIC 90 kDa subunit
    general transcription factor IIIC 4
    transcription factor IIIC 90 kDa subunit
    transcription factor IIIC subunit delta
    NP_001159505.1
    NP_766565.2
    XP_006498141.1
    XP_036018130.1
    XP_036018131.1
    XP_036018132.1
    XP_036018133.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166033.1 → NP_001159505.1  general transcription factor 3C polypeptide 4 isoform 2

      See identical proteins and their annotated locations for NP_001159505.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon compared to variant 1, that causes a frameshift and a downstream translation start site to be used. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
      Source sequence(s)
      AL732526, BC117919, BU610856, CN530016
      Consensus CDS
      CCDS50550.1
      UniProtKB/TrEMBL
      E9Q2B0, Q3UJL1
      Related
      ENSMUSP00000132171.2, ENSMUST00000171404.8
      Conserved Domains (2) summary
      pfam12660
      Location:599 → 671
      zf-TFIIIC; Putative zinc-finger of transcription factor IIIC complex
      pfam12657
      Location:1 → 109
      TFIIIC_delta; Transcription factor IIIC subunit delta N-term

    2. NM_172977.3 → NP_766565.2  general transcription factor 3C polypeptide 4 isoform 1

      See identical proteins and their annotated locations for NP_766565.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AL732526, BC117919, CN530016
      Consensus CDS
      CCDS15847.1
      UniProtKB/Swiss-Prot
      Q148Y1, Q8BKZ4, Q8BMQ2
      UniProtKB/TrEMBL
      Q501L4
      Related
      ENSMUSP00000042265.6, ENSMUST00000037117.6
      Conserved Domains (2) summary
      pfam12657
      Location:61 → 250
      TFIIIC_delta; Transcription factor IIIC subunit delta N-term
      pfam12660
      Location:740 → 812
      zf-TFIIIC; Putative zinc-finger of transcription factor IIIC complex

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      28712311..28730628 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162237.1 → XP_036018130.1  general transcription factor 3C polypeptide 4 isoform X1

      UniProtKB/TrEMBL
      Q501L4
      Conserved Domains (1) summary
      pfam12657
      Location:61 → 250
      TFIIIC_delta; Transcription factor IIIC subunit delta N-term

    2. XM_036162239.1 → XP_036018132.1  general transcription factor 3C polypeptide 4 isoform X3

      UniProtKB/TrEMBL
      Q3UJL1
      Conserved Domains (1) summary
      pfam12657
      Location:1 → 109
      TFIIIC_delta; Transcription factor IIIC subunit delta N-term

    3. XM_036162240.1 → XP_036018133.1  general transcription factor 3C polypeptide 4 isoform X3

      UniProtKB/TrEMBL
      Q3UJL1
      Conserved Domains (1) summary
      pfam12657
      Location:1 → 109
      TFIIIC_delta; Transcription factor IIIC subunit delta N-term

    4. XM_006498078.5 → XP_006498141.1  general transcription factor 3C polypeptide 4 isoform X2

      See identical proteins and their annotated locations for XP_006498141.1

      UniProtKB/TrEMBL
      E9Q2B0, Q3UJL1
      Conserved Domains (2) summary
      pfam12660
      Location:599 → 671
      zf-TFIIIC; Putative zinc-finger of transcription factor IIIC complex
      pfam12657
      Location:1 → 109
      TFIIIC_delta; Transcription factor IIIC subunit delta N-term

    5. XM_036162238.1 → XP_036018131.1  general transcription factor 3C polypeptide 4 isoform X2

      UniProtKB/TrEMBL
      E9Q2B0, Q3UJL1
      Conserved Domains (2) summary
      pfam12660
      Location:599 → 671
      zf-TFIIIC; Putative zinc-finger of transcription factor IIIC complex
      pfam12657
      Location:1 → 109
      TFIIIC_delta; Transcription factor IIIC subunit delta N-term
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BMQ2.2 GenPept UniProtKB/Swiss-Prot:Q8BMQ2

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