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    Atp13a5 ATPase type 13A5 [ Mus musculus (house mouse) ]

    Gene ID: 268878, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Atp13a5provided by MGI
    Official Full Name
    ATPase type 13A5provided by MGI
    Primary source
    MGI:MGI:2444068
    See related
    Ensembl:ENSMUSG00000048939 AllianceGenome:MGI:2444068
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    C630015F21Rik
    Summary
    Predicted to enable ATPase-coupled monoatomic cation transmembrane transporter activity and polyamine transmembrane transporter activity. Predicted to be involved in intracellular calcium ion homeostasis and polyamine transmembrane transport. Predicted to be located in membrane. Predicted to be active in late endosome membrane. Is expressed in several structures, including dentate gyrus subgranular zone; lung; musculature; sensory organ; and urinary system. Orthologous to human ATP13A5 (ATPase 13A5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cortex adult (RPKM 2.3), frontal lobe adult (RPKM 2.2) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Atp13a5 in Genome Data Viewer
    Location:
    16 B2; 16 20.03 cM
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (29049242..29208807, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (29230490..29378766, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene Mab-21 domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_40518 Neighboring gene STARR-seq mESC enhancer starr_40520 Neighboring gene predicted gene 8253 Neighboring gene STARR-seq mESC enhancer starr_40521 Neighboring gene phospholipase A and acyltransferase 1 Neighboring gene STARR-seq mESC enhancer starr_40522 Neighboring gene STARR-seq mESC enhancer starr_40523 Neighboring gene ATPase type 13A4 Neighboring gene zinc finger protein 788 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:29579308-29579525 Neighboring gene STARR-seq mESC enhancer starr_40527 Neighboring gene OPA1, mitochondrial dynamin like GTPase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled monoatomic cation transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATPase-coupled monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables P-type ion transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polyamine transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable cation-transporting ATPase 13A5
    Names
    P5-ATPase
    NP_001271304.1
    NP_783581.2
    XP_006522259.1
    XP_036015848.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001284375.1 → NP_001271304.1  probable cation-transporting ATPase 13A5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' coding region compared to variant 1. This results in a shorter isoform (2), when compared to isoform 1.
      Source sequence(s)
      AC154421, AC175464, BC115739, CB524474
      Consensus CDS
      CCDS70705.1
      UniProtKB/TrEMBL
      D3YU82
      Related
      ENSMUSP00000121208.2, ENSMUST00000143373.8
      Conserved Domains (6) summary
      TIGR01657
      Location:24 → 1073
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
      pfam00122
      Location:206 → 426
      E1-E2_ATPase; E1-E2 ATPase
      pfam00690
      Location:170 → 202
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12409
      Location:23 → 137
      P5-ATPase; P5-type ATPase cation transporter
      pfam13246
      Location:549 → 592
      Cation_ATPase; Cation transport ATPase (P-type)
      cl21460
      Location:778 → 828
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    2. NM_175650.4 → NP_783581.2  probable cation-transporting ATPase 13A5 isoform 1

      See identical proteins and their annotated locations for NP_783581.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK083121, AK158355
      Consensus CDS
      CCDS28095.1
      UniProtKB/Swiss-Prot
      Q14BM0, Q3TYU2, Q8BUP1
      Related
      ENSMUSP00000075204.5, ENSMUST00000075806.11
      Conserved Domains (6) summary
      TIGR01657
      Location:24 → 1118
      P-ATPase-V; P-type ATPase of unknown pump specificity (type V)
      pfam00122
      Location:228 → 471
      E1-E2_ATPase; E1-E2 ATPase
      pfam00690
      Location:170 → 239
      Cation_ATPase_N; Cation transporter/ATPase, N-terminus
      pfam12409
      Location:23 → 137
      P5-ATPase; P5-type ATPase cation transporter
      pfam13246
      Location:594 → 637
      Cation_ATPase; Cation transport ATPase (P-type)
      cl21460
      Location:823 → 873
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      29049242..29208807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159955.1 → XP_036015848.1  probable cation-transporting ATPase 13A5 isoform X2

      Conserved Domains (2) summary
      cd07542
      Location:156 → 981
      P-type_ATPase_cation; P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p
      pfam12409
      Location:3 → 124
      P5-ATPase; P5-type ATPase cation transporter

    2. XM_006522196.5 → XP_006522259.1  probable cation-transporting ATPase 13A5 isoform X1

      Conserved Domains (2) summary
      cd07542
      Location:160 → 985
      P-type_ATPase_cation; P-type cation-transporting ATPases, similar to human ATPase type 13A2 (ATP13A2) protein and Saccharomyces cerevisiae Ypk9p
      pfam12409
      Location:23 → 137
      P5-ATPase; P5-type ATPase cation transporter
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TYU2.2 GenPept UniProtKB/Swiss-Prot:Q3TYU2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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