Or2w4 olfactory receptor family 2 subfamily W member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Or2w4provided by MGI
Official Full Name: olfactory receptor family 2 subfamily W member 4provided by MGI
Primary source: MGI:MGI:3031196
See related: Ensembl:ENSMUSG00000051258 AllianceGenome:MGI:3031196
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MOR256-8; Olfr1362; Olfr1363-ps1
Summary: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
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Genomic context

Location:: 13 A3.1; 13 7.88 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (21795190..21796174, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (21611020..21612004, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

a single mutation in MOR256-8 was sufficient to confer both high basal activity and broad responsiveness to this receptor.
Title: Responsiveness of G protein-coupled odorant receptors is partially attributed to the activation mechanism.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables olfactory receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables olfactory receptor activity	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISA Inferred from Sequence Alignment more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of smell	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception of smell	ISA Inferred from Sequence Alignment more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISA Inferred from Sequence Alignment more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: olfactory receptor 1362

Names: GA_x6K02T2QHY8-11617756-11618682; GA_x6K02T2QHY8-11628399-11628868; olfactory receptor 1363, pseudogene 1; olfactory receptor MOR256-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_146744.2 → NP_666955.2 olfactory receptor 1362

Status: VALIDATED

Source sequence(s)

AL589651, BC119336

Consensus CDS

CCDS26282.1

UniProtKB/TrEMBL

Q5SZZ8, Q7TQU2

Related

ENSMUSP00000061660.3, ENSMUST00000051874.6

Conserved Domains (2) summary

pfam00001
Location:41 → 290

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:34 → 304

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

21795190..21796174 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NG_003404.2: Suppressed sequence

Description

NG_003404.2: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.