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    BRMS1 BRMS1 transcriptional repressor and anoikis regulator [ Homo sapiens (human) ]

    Gene ID: 25855, updated on 2-Nov-2024

    Summary

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    Official Symbol
    BRMS1provided by HGNC
    Official Full Name
    BRMS1 transcriptional repressor and anoikis regulatorprovided by HGNC
    Primary source
    HGNC:HGNC:17262
    See related
    Ensembl:ENSG00000174744 MIM:606259; AllianceGenome:HGNC:17262
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 18.9), testis (RPKM 16.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See BRMS1 in Genome Data Viewer
    Location:
    11q13.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (66337339..66345104, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (66330994..66338767, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66104810..66112575, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:66083264-66083960 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3588 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:66086517-66087018 Neighboring gene CD248 molecule Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:66087019-66087518 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66093768-66094517 Neighboring gene Ras and Rab interactor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:66104385-66105239 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:66112315-66112865 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3589 Neighboring gene beta-1,4-glucuronyltransferase 1 Neighboring gene tRNA-Ser (anticodon GCT) 3-1 Neighboring gene B4GAT1 divergent transcript

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a novel human BRMS1 transcript variant in hepatocellular carcinoma cells. Wu J, et al. Cancer Lett, 2013 Sep 1. PMID 23643861
    2. BRMS1 expression alters the ultrastructural, biomechanical and biochemical properties of MDA-MB-435 human breast carcinoma cells: an AFM and Raman microspectroscopy study. Wu Y, et al. Cancer Lett, 2010 Jul 1. PMID 20083343
    3. Prognostic significance of BRMS1 expression in human melanoma and its role in tumor angiogenesis. Li J, et al. Oncogene, 2011 Feb 24. PMID 20935672, Free PMC Article
    4. Promoter methylation of BRMS1 correlates with smoking history and poor survival in non-small cell lung cancer patients. Yang J, et al. Lung Cancer, 2011 Nov. PMID 21726917
    5. mRNA expression of the putative antimetastatic gene BRMS1 and of apoptosis-related genes in breast cancer. Schneider J, et al. Cancer Genomics Proteomics, 2011 Jul-Aug. PMID 21737612

    See all (126) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Perturbation of BRMS1 interactome reveals pathways that impact metastasis.
      Title: Perturbation of BRMS1 interactome reveals pathways that impact metastasis.
    2. Distinct expression and function of breast cancer metastasis suppressor 1 in mutant P53 glioblastoma.
      Title: Distinct expression and function of breast cancer metastasis suppressor 1 in mutant P53 glioblastoma.
    3. A germline SNP in BRMS1 predisposes patients with lung adenocarcinoma to metastasis and can be ameliorated by targeting c-fos.
      Title: A germline SNP in BRMS1 predisposes patients with lung adenocarcinoma to metastasis and can be ameliorated by targeting c-fos.
    4. N6-Methyladenosine modification of the TRIM7 positively regulates tumorigenesis and chemoresistance in osteosarcoma through ubiquitination of BRMS1.
      Title: N6-Methyladenosine modification of the TRIM7 positively regulates tumorigenesis and chemoresistance in osteosarcoma through ubiquitination of BRMS1.
    5. suggest that BRMS! NLS2 is a disordered region, with non pre-formed structure, that participates in metastasis suppression
      Title: The isolated C-terminal nuclear localization sequence of the breast cancer metastasis suppressor 1 is disordered.
    6. BRMS1 gene expression and anti-metastatic role in the breast cancer.
      Title: Additive effect of metastamiR-193b and breast cancer metastasis suppressor 1 as an anti-metastatic strategy.
    7. BRMS1FANCI interaction is necessary for the regulatory role of BRMS1 in the FA pathway.
      Title: BRMS1 participates in regulating cell sensitivity to DNA interstrand crosslink damage by interacting with FANCI.
    8. overexpression of miR-3200-5p significantly decreased BRMS1 levels and promoted OS cell invasion and migration, while depletion of miR-3200-5p significantly increased BRMS1 levels and inhibited OS cell invasion and migration. Study revealed that miR-3200-5p may be a critical regulator of OS cell invasiveness.
      Title: MicroRNA-3200-5p Promotes Osteosarcoma Cell Invasion via Suppression of BRMS1.
    9. Low BRMS1 expression is associated with Hepatocellular carcinoma.
      Title: miR-346 Promotes HCC Progression by Suppressing Breast Cancer Metastasis Suppressor 1 Expression.
    10. Low BRMS1 expression is associated with high metastatic capacity of breast cancer.
      Title: Breast cancer metastasis suppressor gene, breast cancer metastasis suppressor 1, may be associated with clinicopathological features of breast cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (78)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp564A063

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NF-kappaB binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone deacetylase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cell migration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of stem cell population maintenance NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of transforming growth factor beta receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of anoikis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein deacetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of stem cell population maintenance NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Sin3-type complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    breast cancer metastasis-suppressor 1
    Names
    breast cancer metastasis suppressor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024957.2 → NP_001020128.1  breast cancer metastasis-suppressor 1 isoform 2

      See identical proteins and their annotated locations for NP_001020128.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' terminal exon which results in the use of a downstream stop codon, compared to variant 1. The encoded protein (isoform 2) has a longer and distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AP001107, BM312965, CB130346, CB529276
      Consensus CDS
      CCDS44654.1
      UniProtKB/TrEMBL
      E9PJF5, G5E9I4
      Related
      ENSP00000396052.2, ENST00000425825.6
      Conserved Domains (1) summary
      pfam08598
      Location:60 → 177
      Sds3; Sds3-like

    2. NM_015399.4 → NP_056214.1  breast cancer metastasis-suppressor 1 isoform 1

      See identical proteins and their annotated locations for NP_056214.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest and more abundant transcript and encodes isoform (1).
      Source sequence(s)
      AP001107, BU734281, CB130346
      Consensus CDS
      CCDS8135.1
      UniProtKB/Swiss-Prot
      Q6IAI2, Q9HCU9
      UniProtKB/TrEMBL
      E9PJF5
      Related
      ENSP00000353042.3, ENST00000359957.8
      Conserved Domains (1) summary
      pfam08598
      Location:60 → 178
      Sds3; Sds3-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      66337339..66345104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448426.2 → XP_024304194.1  breast cancer metastasis-suppressor 1 isoform X2

      UniProtKB/TrEMBL
      E9PJF5
      Conserved Domains (1) summary
      pfam08598
      Location:60 → 178
      Sds3; Sds3-like

    2. XM_024448425.2 → XP_024304193.1  breast cancer metastasis-suppressor 1 isoform X1

      UniProtKB/TrEMBL
      H0YCF7
      Related
      ENSP00000431510.1, ENST00000524699.5
      Conserved Domains (1) summary
      pfam08598
      Location:60 → 178
      Sds3; Sds3-like

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      66330994..66338767 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368347.1 → XP_054224322.1  breast cancer metastasis-suppressor 1 isoform X2

    2. XM_054368346.1 → XP_054224321.1  breast cancer metastasis-suppressor 1 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001024958.1: Suppressed sequence

      Description
      NM_001024958.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HCU9.1 GenPept UniProtKB/Swiss-Prot:Q9HCU9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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