cgs1 cAMP-dependent protein kinase regulatory subunit Cgs1 [Schizosaccharomyces pombe (fission yeast)] - Gene

Summary

Gene symbol: cgs1
Gene description: cAMP-dependent protein kinase regulatory subunit Cgs1
Primary source: FungiDB:SPAC8C9.03
Locus tag: SPAC8C9.03
See related: VEuPathDB:SPAC8C9.03
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Schizosaccharomyces pombe (strain: 972h-)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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Chromosome I - NC_003424.3 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

hyperphosphorylation of Pka1 depends on Cgs1 interaction.
Title: Multistep regulation of protein kinase A in its localization, phosphorylation and binding with a regulatory subunit in fission yeast.
In the tor2-51 cgs1Delta double mutant no G1-arrested cells were observed 8 hours after Tor2 inactivation, indicating that the TOR and the PKA pathways cooperate to prevent cell cycle exit and G1 arrest in fission yeast.
Title: TOR and PKA pathways synergize at the level of the Ste11 transcription factor to prevent mating and meiosis in fission yeast.
Nuclear-cytoplasmic redistribution of Cgs1p and Pka1p is triggered by growth in glucose-limited or hyperosmotic media and in response to stationary-phase growth.
Title: Regulation of the subcellular localization of cyclic AMP-dependent protein kinase in response to physiological stresses and sexual differentiation in the fission yeast Schizosaccharomyces pombe.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables cAMP binding	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables cAMP-dependent protein kinase inhibitor activity	EXP Inferred from Experiment more info	PubMed
enables cAMP-dependent protein kinase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP-dependent protein kinase inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A catalytic subunit binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to glucose starvation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway	IC Inferred by Curator more info
involved_in negative regulation of cAMP-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of cAMP-dependent protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cAMP-dependent protein kinase complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed

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