Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cacna2d1provided by RGD
Official Full Name: calcium voltage-gated channel auxiliary subunit alpha2delta 1provided by RGD
Primary source: RGD:2247
See related: EnsemblRapid:ENSRNOG00000033531 AllianceGenome:RGD:2247
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CCHLA2; Cacna2; DHSCCA
Summary: Enables voltage-gated calcium channel activity. Involved in calcium ion transmembrane transport; positive regulation of voltage-gated calcium channel activity; and regulation of membrane repolarization during action potential. Part of L-type voltage-gated calcium channel complex. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic active zone membrane. Biomarker of brain infarction. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 110. Orthologous to human CACNA2D1 (calcium voltage-gated channel auxiliary subunit alpha2delta 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 1317.2), Brain (RPKM 301.1) and 4 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q12

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (19902324..20330287, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (18950611..19374969, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (15706974..16130848, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of voltage-gated calcium channel alpha2delta-1 in the occurrence and development in myofascial orofacial pain.
Title: The role of voltage-gated calcium channel α2δ-1 in the occurrence and development in myofascial orofacial pain.
Sympathetic Stimulation Upregulates the Ca(2+) Channel Subunit, CaValpha2delta1, via the beta1 and ERK 1/2 Pathway in Neonatal Ventricular Cardiomyocytes.
Title: Sympathetic Stimulation Upregulates the Ca(2+) Channel Subunit, Ca(V)α2δ1, via the β1 and ERK 1/2 Pathway in Neonatal Ventricular Cardiomyocytes.
The alpha2delta-1-NMDAR1 interaction in the trigeminal ganglion contributes to orofacial ectopic pain following inferior alveolar nerve injury.
Title: The α2δ-1-NMDAR1 interaction in the trigeminal ganglion contributes to orofacial ectopic pain following inferior alveolar nerve injury.
Rab11-dependent recycling of calcium channels is mediated by auxiliary subunit alpha2delta-1 but not alpha2delta-3.
Title: Rab11-dependent recycling of calcium channels is mediated by auxiliary subunit α(2)δ-1 but not α(2)δ-3.
The TCF7L2-dependent high-voltage activated calcium channel subunit alpha2delta-1 controls calcium signaling in rodent pancreatic beta-cells.
Title: The TCF7L2-dependent high-voltage activated calcium channel subunit α2δ-1 controls calcium signaling in rodent pancreatic beta-cells.
These observations prompt to consider alpha2delta-1 as an outside-in signaling platform that binds exogenous and endogenous cues for regulating the coupling of voltage-gated calcium channels to synaptic vesicles.
Title: Outside-in regulation of the readily releasable pool of synaptic vesicles by α2δ-1.
High alpha2delta-1 expression is associated with hypertension.
Title: α2δ-1 couples to NMDA receptors in the hypothalamus to sustain sympathetic vasomotor activity in hypertension.
alpha2delta-1-NMDAR complexes in the hypothalamus serve as an important molecular substrate for the interaction between the sympathetic nervous system and the renin-angiotensin system
Title: α2δ-1 Is Essential for Sympathetic Output and NMDA Receptor Activity Potentiated by Angiotensin II in the Hypothalamus.
Cacna2d1 overexpression potentiates presynaptic and postsynaptic NMDAR activity of spinal dorsal horn neurons to cause pain hypersensitivity.
Title: The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions.
An increase of alpha2delta-1 in the L4 and L5 dorsal horns after thoracic spinal cord injury is derived from the increase in the expression in lumbar spinal neurons
Title: Upregulation of calcium channel alpha-2-delta-1 subunit in dorsal horn contributes to spinal cord injury-induced tactile allodynia.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH144502 (e-PCR)
- UniSTS:233747

AU048127 (e-PCR)
- UniSTS:109845

RH139155 (e-PCR)
- UniSTS:221241

Cacna2d1 (e-PCR), detects polymorphism
- UniSTS:166208

d4rat149 (e-PCR)
- UniSTS:121967

BE117531 (e-PCR)
- UniSTS:248696

RH142303 (e-PCR)
- UniSTS:231550

Cacna2d1 (e-PCR), detects polymorphism
- UniSTS:498316

RH131169 (e-PCR)
- UniSTS:214452

AU048896 (e-PCR)
- UniSTS:145346

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables voltage-gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated calcium channel activity involved in bundle of His cell action potential	IEA Inferred from Electronic Annotation more info
contributes_to voltage-gated calcium channel activity involved in bundle of His cell action potential	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport via high voltage-gated calcium channel	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	TAS Traceable Author Statement more info	PubMed
involved_in calcium ion transport into cytosol	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiac muscle cell action potential involved in contraction	IEA Inferred from Electronic Annotation more info
involved_in cardiac muscle cell action potential involved in contraction	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amyloid-beta	IEA Inferred from Electronic Annotation more info
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during bundle of His cell action potential	IEA Inferred from Electronic Annotation more info
involved_in membrane depolarization during bundle of His cell action potential	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of voltage-gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	IEA Inferred from Electronic Annotation more info
involved_in regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate by cardiac conduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane repolarization during action potential	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	IEA Inferred from Electronic Annotation more info
involved_in regulation of ventricular cardiac muscle cell membrane repolarization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in GABA-ergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
part_of L-type voltage-gated calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of L-type voltage-gated calcium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of L-type voltage-gated calcium channel complex	IEA Inferred from Electronic Annotation more info
part_of L-type voltage-gated calcium channel complex	ISO Inferred from Sequence Orthology more info
located_in T-tubule	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
located_in neuronal dense core vesicle	IEA Inferred from Electronic Annotation more info
is_active_in neuronal dense core vesicle	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic active zone membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
part_of voltage-gated calcium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of voltage-gated calcium channel complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: voltage-dependent calcium channel subunit alpha-2/delta-1

Names: Calcium channel subunit alpha 2 delta (dihydropyridine - sensitive L-type); calcium channel, voltage-dependent, alpha2/delta subunit 1; voltage-gated calcium channel subunit alpha-2/delta-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001110847.1 → NP_001104317.1 voltage-dependent calcium channel subunit alpha-2/delta-1 isoform 3 precursor

See identical proteins and their annotated locations for NP_001104317.1

Status: PROVISIONAL

Source sequence(s)

AF400662

UniProtKB/Swiss-Prot

P54290

UniProtKB/TrEMBL

Q8VHS9

Related

ENSRNOP00000103184.1, ENSRNOT00000140780.1

Conserved Domains (5) summary

cd01463
Location:239 → 417

vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...

pfam02743
Location:446 → 530

Cache_1; Cache domain

pfam08399
Location:104 → 223

VWA_N; VWA N-terminal

pfam08473
Location:538 → 622

VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd

cl21471
Location:537 → 804

RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein
NM_001110848.1 → NP_001104318.1 voltage-dependent calcium channel subunit alpha-2/delta-1 isoform 2 precursor

See identical proteins and their annotated locations for NP_001104318.1

Status: PROVISIONAL

Source sequence(s)

AF486276

UniProtKB/Swiss-Prot

P54290

UniProtKB/TrEMBL

Q8CFG7

Conserved Domains (5) summary

cd01463
Location:239 → 417

vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...

pfam02743
Location:446 → 531

Cache_1; Cache domain

pfam08399
Location:104 → 223

VWA_N; VWA N-terminal

pfam08473
Location:543 → 627

VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd

cl21471
Location:623 → 809

RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein
NM_012919.3 → NP_037051.2 voltage-dependent calcium channel subunit alpha-2/delta-1 isoform 1 precursor

See identical proteins and their annotated locations for NP_037051.2

Status: PROVISIONAL

Source sequence(s)

AF286488

UniProtKB/Swiss-Prot

P54290

UniProtKB/TrEMBL

F7F134, Q9ERS3

Related

ENSRNOP00000105396.1, ENSRNOT00000156499.1

Conserved Domains (5) summary

cd01463
Location:239 → 417

vWA_VGCC_like; VWA Voltage gated Calcium channel like: Voltage-gated calcium channels are a complex of five proteins: alpha 1, beta 1, gamma, alpha 2 and delta. The alpha 2 and delta subunits result from proteolytic processing of a single gene product and carries at ...

pfam02743
Location:446 → 531

Cache_1; Cache domain

pfam08399
Location:104 → 223

VWA_N; VWA N-terminal

pfam08473
Location:543 → 627

VGCC_alpha2; Neuronal voltage-dependent calcium channel alpha 2acd

cl21471
Location:636 → 816

RAMP_I_III; CRISPR/Cas system-associated RAMP superfamily protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

19902324..20330287 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063285606.1 → XP_063141676.1 voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X3

UniProtKB/Swiss-Prot

P54290

Related

ENSRNOP00000074655.3, ENSRNOT00000082161.3
XM_063285608.1 → XP_063141678.1 voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X5

UniProtKB/Swiss-Prot

P54290
XM_063285607.1 → XP_063141677.1 voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X4

UniProtKB/Swiss-Prot

P54290
XM_063285605.1 → XP_063141675.1 voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X2

UniProtKB/Swiss-Prot

P54290
XM_063285604.1 → XP_063141674.1 voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1

UniProtKB/Swiss-Prot

P54290
XM_063285611.1 → XP_063141681.1 voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X8
XM_063285609.1 → XP_063141679.1 voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X6
XM_063285610.1 → XP_063141680.1 voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X7