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    ubp12 CSN-associated deubiquitinating enzyme Ubp12 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538990, updated on 22-Jun-2024

    Summary

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    Gene symbol
    ubp12
    Gene description
    CSN-associated deubiquitinating enzyme Ubp12
    Locus tag
    SPOM_SPCC1494.05C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Old locus tag
    SPCC1494.05c
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    Genomic context

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    See ubp12 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (2328869..2332471, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene armadillo repeat-containing zfs1 target protein 1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NADP-dependent prephenate dehydrogenase Tyr1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ATP-dependent RNA helicase Dbp9 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fission yeast COP9/signalosome suppresses cullin activity through recruitment of the deubiquitylating enzyme Ubp12p. Zhou C, et al. Mol Cell, 2003 Apr. PMID 12718879
    2. CSN facilitates Cullin-RING ubiquitin ligase function by counteracting autocatalytic adapter instability. Wee S, et al. Nat Cell Biol, 2005 Apr. PMID 15793566
    3. Orderly progression through S-phase requires dynamic ubiquitylation and deubiquitylation of PCNA. Álvarez V, et al. Sci Rep, 2016 May 6. PMID 27151298, Free PMC Article
    4. A global census of fission yeast deubiquitinating enzyme localization and interaction networks reveals distinct compartmentalization profiles and overlapping functions in endocytosis and polarity. Kouranti I, et al. PLoS Biol, 2010 Sep 7. PMID 20838651, Free PMC Article
    5. Yeast SREBP cleavage activation requires the Golgi Dsc E3 ligase complex. Stewart EV, et al. Mol Cell, 2011 Apr 22. PMID 21504829, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal-dependent deubiquitinase activity HDA PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CSN-associated deubiquitinating enzyme Ubp12

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      2328869..2332471 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023518.3 → NP_588530.1  CSN-associated deubiquitinating enzyme Ubp12 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588530.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O60079
      Conserved Domains (5) summary
      smart00695
      Location:69 → 155
      DUSP; Domain in ubiquitin-specific proteases
      COG5560
      Location:33 → 978
      UBP12; Ubiquitin C-terminal hydrolase [Posttranslational modification, protein turnover, chaperones]
      cd02674
      Location:825 → 975
      Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
      cl02553
      Location:312 → 513
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam14533
      Location:519 → 648
      USP7_C2; Ubiquitin-specific protease C-terminal
    Nucleotide Protein
    Heading Accession and Version

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