Mlnr motilin receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mlnrprovided by RGD
Official Full Name: motilin receptorprovided by RGD
Primary source: RGD:621262
See related: EnsemblRapid:ENSRNOG00000012789 AllianceGenome:RGD:621262
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Trhr2
Summary: Enables thyrotropin-releasing hormone receptor activity. Predicted to be involved in phospholipase C-activating G protein-coupled receptor signaling pathway. Located in neuronal cell body. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 17.3) See more
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Genomic context

Location:: 19q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (67317269..67340508, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (50413570..50422842, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (55176617..55183562, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The expression and localization of TRH-R1 and TRH-R2 in postnatal development and ethane dimethane sulfonate treated rat testes were observed.
Title: Expression of thyrotropin-releasing hormone receptors in rat testis and their role in isolated Leydig cells.
Data showed consistent expression for TRH-R2 in 6-23 C-cells and in PC C13 follicular cells.
Title: Thyrotropin-releasing hormone receptor expression in thyroid follicular cells: a new paracrine role of C-cells?

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables thyrotropin-releasing hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables thyrotropin-releasing hormone receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: motilin receptor

Names: thyrotropin releasing hormone receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181364.5 → NP_852029.3 motilin receptor

See identical proteins and their annotated locations for NP_852029.3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/TrEMBL

A6IZR3, F7ER42, O88820, Q9QWW3, Q9R297

Related

ENSRNOP00000017317.2, ENSRNOT00000017317.6

Conserved Domains (2) summary

pfam00001
Location:39 → 305

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:37 → 161

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

67317269..67340508 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063277788.1 → XP_063133858.1 motilin receptor isoform X1

UniProtKB/TrEMBL

A6IZR3, F7ER42, Q9R297
XM_017601176.3 → XP_017456665.1 motilin receptor isoform X1

Conserved Domains (2) summary

pfam00001
Location:39 → 305

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:37 → 161

7tm_4; Olfactory receptor